ID   M3XRI0_MUSPF            Unreviewed;       377 AA.
AC   M3XRI0;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   SubName: Full=Retinol dehydrogenase 16 {ECO:0000313|Ensembl:ENSMPUP00000001680.1};
GN   Name=RDH16 {ECO:0000313|Ensembl:ENSMPUP00000001680.1};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000001680.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000001680.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC       family. {ECO:0000256|RuleBase:RU000363}.
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DR   EMBL; AEYP01080285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004773221.1; XM_004773164.2.
DR   AlphaFoldDB; M3XRI0; -.
DR   STRING; 9669.ENSMPUP00000001680; -.
DR   Ensembl; ENSMPUT00000001715.1; ENSMPUP00000001680.1; ENSMPUG00000001697.1.
DR   GeneID; 101674025; -.
DR   KEGG; mpuf:101674025; -.
DR   CTD; 8608; -.
DR   eggNOG; KOG1610; Eukaryota.
DR   GeneTree; ENSGT00940000154118; -.
DR   HOGENOM; CLU_010194_2_0_1; -.
DR   InParanoid; M3XRI0; -.
DR   OMA; AQYSINI; -.
DR   OrthoDB; 5403248at2759; -.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0047044; F:androstan-3-alpha,17-beta-diol dehydrogenase activity; IEA:Ensembl.
DR   GO; GO:0047023; F:androsterone dehydrogenase activity; IEA:Ensembl.
DR   GO; GO:0004745; F:NAD-retinol dehydrogenase activity; IEA:Ensembl.
DR   GO; GO:0008202; P:steroid metabolic process; IEA:Ensembl.
DR   CDD; cd09805; type2_17beta_HSD-like_SDR_c; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR   InterPro; IPR002347; SDR_fam.
DR   PANTHER; PTHR43313:SF11; RETINOL DEHYDROGENASE 16; 1.
DR   PANTHER; PTHR43313; SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY 9C; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        60..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        349..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   377 AA;  41603 MW;  323EC014F60A43C3 CRC64;
     MGSDQPGGEG DLWGEVPGVW APLEISVQRF AATSLHPPGA SAGFLVRAPT APSLCVTCKA
     MWLCLVALVG LYFFLRWYRE RQVVSHLQDK FVFITGCDSG FGNLLARQLD LRGLRVLAAC
     LTEEGAQQLR GQTSDRLETV ILDVTKTESI SAAAQWVKER VGDRGLWGLV NNAGVSVPTA
     PNEWLTKHDF MKILDVNLLG LLEVTLSLLS LVRKARGRVV NVSSIMGRLS VLGGGYCISK
     YGVEAFSDSL RRELSYFGVK VAVIEPGYFS TNISSPEKIS RATQEAWDQA SPEVKEIYGE
     KFLASFKKSI EKLESLCCNN LYLVTDCMEH ALTARHPRTR YSPGWDAKLF YLPMSYMPTV
     LVDAIISWSS LKPLKAL
//