ID   M3XU85_MUSPF            Unreviewed;       477 AA.
AC   M3XU85;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   01-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 48.
DE   RecName: Full=Keratin, type II cytoskeletal 8 {ECO:0000256|ARBA:ARBA00039429};
DE   AltName: Full=Cytokeratin-8 {ECO:0000256|ARBA:ARBA00042964};
DE   AltName: Full=Keratin-8 {ECO:0000256|ARBA:ARBA00042886};
DE   AltName: Full=Type-II keratin Kb8 {ECO:0000256|ARBA:ARBA00043133};
OS   Mustela putorius furo (European domestic ferret) (Mustela furo).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC   Mustelinae; Mustela.
OX   NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000002635.1};
RN   [1] {ECO:0000313|Ensembl:ENSMPUP00000002635.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2023) to UniProtKB.
CC   -!- FUNCTION: Together with KRT19, helps to link the contractile apparatus
CC       to dystrophin at the costameres of striated muscle.
CC       {ECO:0000256|ARBA:ARBA00037766}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus matrix {ECO:0000256|ARBA:ARBA00004109}.
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DR   EMBL; AEYP01029812; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; M3XU85; -.
DR   STRING; 9669.ENSMPUP00000002635; -.
DR   Ensembl; ENSMPUT00000002690.1; ENSMPUP00000002635.1; ENSMPUG00000002664.1.
DR   eggNOG; ENOG502QURK; Eukaryota.
DR   GeneTree; ENSGT00940000153339; -.
DR   HOGENOM; CLU_012560_5_4_1; -.
DR   InParanoid; M3XU85; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   GO; GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR032444; Keratin_2_head.
DR   InterPro; IPR003054; Keratin_II.
DR   PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45616:SF26; KERATIN, TYPE II CYTOSKELETAL 8; 1.
DR   Pfam; PF00038; Filament; 1.
DR   Pfam; PF16208; Keratin_2_head; 1.
DR   PRINTS; PR01276; TYPE2KERATIN.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754};
KW   Keratin {ECO:0000256|ARBA:ARBA00022744};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT   DOMAIN          99..397
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   COILED          296..361
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   477 AA;  52245 MW;  285A973657A522B4 CRC64;
     PSLLTNSVWT RSSFSAPYRT SVRFSLLAST PASTLASTMS VGGVGSFWGG LNSSRSVVRG
     YGCGAEGMGS ITAVSVNQSL LSPLKLEADP NIQAVRTQEK EQVKTLNKPA SFPDTARHLE
     QQNKIRETKR SLLQQQKTAR SNPDMLESCI SNLRWPWTPG PEKLKPEAEE DFRGQCKELL
     REHADVENEF VLIKKDVDEA YKNKVELESC LEGLTNDIRF LRGTCEEICE LQSQISDMSV
     VLSMDNSCSL RLDGIITEVK AQYEDFANRS RPQAETLYQI KHEELQTLAG KHGDVLRRTK
     TEISELNWSI GQLQAEIEAL QNQAALEAAS ADAEQHGELA IKDANAKVAE LEATLLQAKQ
     DMAGHLCKCP ELMNVELALN IKITTYRKRL EGKQSRLESG TLSTRIHTKT SSSYSCGLSS
     AHGGLPNPGL NYSLSSFQAN FGPAGSFSGS SSSKAVVVKK IDIVTGSWCP SHVMSCP
//