ID M3Y2A4_MUSPF Unreviewed; 421 AA.
AC M3Y2A4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Farnesyl pyrophosphate synthase {ECO:0000256|ARBA:ARBA00034546};
DE AltName: Full=(2E,6E)-farnesyl diphosphate synthase {ECO:0000256|ARBA:ARBA00032873};
DE AltName: Full=Dimethylallyltranstransferase {ECO:0000256|ARBA:ARBA00032448};
DE AltName: Full=Farnesyl diphosphate synthase {ECO:0000256|ARBA:ARBA00032424};
DE AltName: Full=Geranyltranstransferase {ECO:0000256|ARBA:ARBA00032380};
GN Name=FDPS {ECO:0000313|RefSeq:XP_004778625.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000005455.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000005455.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004778625.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004778625.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2E)-geranyl diphosphate + isopentenyl diphosphate = (2E,6E)-
CC farnesyl diphosphate + diphosphate; Xref=Rhea:RHEA:19361,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:58057, ChEBI:CHEBI:128769,
CC ChEBI:CHEBI:175763; EC=2.5.1.10;
CC Evidence={ECO:0000256|ARBA:ARBA00001744};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=dimethylallyl diphosphate + isopentenyl diphosphate = (2E)-
CC geranyl diphosphate + diphosphate; Xref=Rhea:RHEA:22408,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57623, ChEBI:CHEBI:58057,
CC ChEBI:CHEBI:128769; EC=2.5.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000969};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis;
CC farnesyl diphosphate from geranyl diphosphate and isopentenyl
CC diphosphate: step 1/1. {ECO:0000256|ARBA:ARBA00005035}.
CC -!- PATHWAY: Isoprenoid biosynthesis; geranyl diphosphate biosynthesis;
CC geranyl diphosphate from dimethylallyl diphosphate and isopentenyl
CC diphosphate: step 1/1. {ECO:0000256|ARBA:ARBA00004932}.
CC -!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
CC {ECO:0000256|RuleBase:RU004466}.
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DR EMBL; AEYP01094755; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01094756; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004778625.1; XM_004778568.3.
DR RefSeq; XP_004778626.1; XM_004778569.2.
DR STRING; 9669.ENSMPUP00000005455; -.
DR Ensembl; ENSMPUT00000005546.1; ENSMPUP00000005455.1; ENSMPUG00000005496.1.
DR GeneID; 101693108; -.
DR KEGG; mpuf:101693108; -.
DR CTD; 2224; -.
DR eggNOG; KOG0711; Eukaryota.
DR GeneTree; ENSGT00900000141074; -.
DR HOGENOM; CLU_028376_0_1_1; -.
DR OMA; LEMGNFF; -.
DR OrthoDB; 509027at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00685; Trans_IPPS_HT; 1.
DR Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 1.
DR InterPro; IPR039702; FPS1-like.
DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR InterPro; IPR000092; Polyprenyl_synt.
DR InterPro; IPR033749; Polyprenyl_synt_CS.
DR PANTHER; PTHR11525:SF0; FARNESYL PYROPHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR11525; FARNESYL-PYROPHOSPHATE SYNTHETASE; 1.
DR Pfam; PF00348; polyprenyl_synt; 1.
DR SFLD; SFLDS00005; Isoprenoid_Synthase_Type_I; 1.
DR SFLD; SFLDG01017; Polyprenyl_Transferase_Like; 1.
DR SUPFAM; SSF48576; Terpenoid synthases; 1.
DR PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
DR PROSITE; PS00444; POLYPRENYL_SYNTHASE_2; 1.
PE 3: Inferred from homology;
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Transferase {ECO:0000256|RuleBase:RU004466}.
SQ SEQUENCE 421 AA; 48099 MW; 1D64F7BCA44C3F27 CRC64;
MMPLSRWLRS VGVFLLPAPC WVPRERWLGP LRRPSLVRGC PVLGAWHGAR CWCQAWTEEP
RALYFSLTMN GDQKSDPYAQ AKQDFIQHFA EIVRVLTEDG VGHPETGDVI ARLKEVLEYN
ATGGKYHRGL TVLIAFRELV EPSKQDAESL GRALTVGWCV ELLQAFLLVC DDIMDSSLTR
RGQICWYQKP GIGLDAINDA LLLEACVYRL LKLCCRQQPY YLNLLELFLQ SSYQTEIGQT
LDLITAPQGN VDLGRFTEKR YKSIVKYKTA FYSFYLPVAA AMYMAGIDGE KQHADAKEIL
LQMGEFFQIQ DDYLDLFGDP AVTGKVGTDI QDNKCSWLVV QCLQRASPEQ RRLLQENYGR
KEAEKVAWVK ALYEELDLPA VFAQYEEDSY ARLMGLIERY ASTLPRTIFL GLARKIYKRT
K
//
