ID M3Y689_MUSPF Unreviewed; 1345 AA.
AC M3Y689;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Peroxidasin like {ECO:0000313|Ensembl:ENSMPUP00000006840.1};
GN Name=PXDNL {ECO:0000313|Ensembl:ENSMPUP00000006840.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000006840.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000006840.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=heme b; Xref=ChEBI:CHEBI:60344;
CC Evidence={ECO:0000256|ARBA:ARBA00001970};
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DR EMBL; AEYP01091330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01091331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01091332; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01091333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01091334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01091335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01091336; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01091337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01091338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01091339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_012903893.1; XM_013048439.1.
DR STRING; 9669.ENSMPUP00000006840; -.
DR Ensembl; ENSMPUT00000006954.1; ENSMPUP00000006840.1; ENSMPUG00000006895.1.
DR KEGG; mpuf:101690178; -.
DR eggNOG; KOG2408; Eukaryota.
DR GeneTree; ENSGT00940000163562; -.
DR HOGENOM; CLU_006087_0_1_1; -.
DR InParanoid; M3Y689; -.
DR OMA; DCVARNS; -.
DR OrthoDB; 4560at2759; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0140825; F:lactoperoxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd09826; peroxidasin_like; 1.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR034824; Peroxidasin_peroxidase.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR PANTHER; PTHR11475:SF38; OXIDOREDUCTASE PXDNL-RELATED; 1.
DR Pfam; PF03098; An_peroxidase; 1.
DR Pfam; PF07679; I-set; 4.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00093; VWC; 1.
DR PRINTS; PR00457; ANPEROXIDASE.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SMART; SM00369; LRR_TYP; 3.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 4.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|PIRSR:PIRSR619791-2};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|PIRSR:PIRSR619791-2};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR619791-2};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 113..201
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 209..293
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 298..383
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 390..475
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1275..1333
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT COILED 1251..1278
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 939
FT /ligand="heme b"
FT /ligand_id="ChEBI:CHEBI:60344"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000256|PIRSR:PIRSR619791-2"
SQ SEQUENCE 1345 AA; 150626 MW; 471F4114007417A0 CRC64;
MSLEQLYIHF NQIETLQAET FGDLLKLERL FLHNNRLSKI PAGSFSHLDS LKRLRLDSNA
LVCDCDLMWL GELMQGYARN GQTQAAATCE YPRRLQGRSI ASLTVEEFNC ESPRITFEPQ
DVEVTSGNTV YFTCRAEGNP KPKIIWIHNN HSLDLEDDSR FNLFDDGTLM IRNTRESDQG
EYQCMARNSA GEVKTQNAML RYSSPPAKPS FIIQPQDTEV LIGTSTTLEC MATGHPHPHV
TWTRGSGEAL DRSRHLTTSG GLYLQNVTLQ DHGQFTCHAD NNQGSVQATA NIIVQAPPQF
RVIPKDQVVL EGHTVKFLCE AEGNPPPIIA WTKAGRQLSQ ESLHTVLSSG TLRIEHAAHY
DQGQYECQAV SPLGVKKVSV QLTVKPKALP VFTQLPQDTS VEVGNNINIS CHAQGEPQPI
ITWNKAGVQI TESGKFHVSG EGMLTIYDAG QADQGRYECV ARNSFGFVVT NMFLTVVAIQ
GRQAGDDFVE SSILDAVQRV DSAINSTRRH LFSQKPRTPG DLLARFRYPH DPFTVETARA
GEIFEHTLLL IQEHVKQGLT VDLEGREFRY NDLVSPHYLS LIANLSGCTA HRQVPNCSDM
CFHQKYRAQD GTCNNLQHPT WGASLTAFER ILKPAYENGF NVPRGVGRHT LSGRLPLPPP
RLVSTELVAT ATVTPDHQYT HMLMQWGQFL DHDLDHTVPA LSTSRFSDGR LCSSECTNDP
PCFPIIIPDS DPRGTGAPCM FFARSSPVCG SGMTSLVMNS VYAREQINQL TAYIDASNIY
GSSERESQIL RDYSEPRGLL RTGLPWVPSG KPLLPFSSGP PTECTRPEQD SRSPCFLAGD
HRANEQLALT AMHTLWFREH NRVVTELSAL NPHWDGDTLY HEARKIVGAQ LQHITYSHWL
PKILGEPGMK MLQDYQGYNP NVNAGIINSF ATAAFRFGHT LINPILYRLN DTFGEIPEGH
LPLHKAFFSP SRIIEEGGID PLLRGLFGVA AKLRVPSQLL SVELTEKLFS MAHSVTLDLA
ATNIQRGRDH GIPPYADFRV FCNLTSVENF EDLQNEIKDS EIRQKLKKLY STPGNIDFWP
ALMVEDLIPG TRVGPTLMCL FVTQFQRLRD GDRFWYENPG VFTPAQLTQL KQASLGRVLC
DNGDNIQQVQ ADVFVKAQYP QDYLSCSEIP QVDLRVWQDC CEDCRSRGQF RAFTQESRKK
RSAQYSYPDE KDKNLSDLLS RQQDYLYIDE DGRHVTFLPK AEFAQDFSNF AVETQKTIKA
LREQINKLEA RLRQAGCTDD KGIRRKDNEH WMKEDCVSCM CKSGQVTCVV ETCPPAPCPS
LELVKGTCCP VCRGPGMPAD SSEKH
//
