ID M3Y7H3_MUSPF Unreviewed; 449 AA.
AC M3Y7H3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=SH2 domain-containing adapter protein E {ECO:0000313|RefSeq:XP_004780368.1};
DE SubName: Full=Src homology 2 domain containing E {ECO:0000313|Ensembl:ENSMPUP00000007280.1};
GN Name=SHE {ECO:0000313|Ensembl:ENSMPUP00000007280.1,
GN ECO:0000313|RefSeq:XP_004780368.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000007280.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000007280.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004780368.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004780368.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AEYP01099934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004780368.1; XM_004780311.3.
DR STRING; 9669.ENSMPUP00000007280; -.
DR Ensembl; ENSMPUT00000007399.1; ENSMPUP00000007280.1; ENSMPUG00000007337.1.
DR GeneID; 101676416; -.
DR KEGG; mpuf:101676416; -.
DR CTD; 126669; -.
DR eggNOG; ENOG502R9PR; Eukaryota.
DR GeneTree; ENSGT00940000159107; -.
DR HOGENOM; CLU_029444_5_0_1; -.
DR OMA; CKTETVI; -.
DR OrthoDB; 2963819at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR CDD; cd10391; SH2_SHE; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035042; SHE_SH2.
DR PANTHER; PTHR15127; HEAVYWEIGHT, ISOFORM A; 1.
DR PANTHER; PTHR15127:SF29; SH2 DOMAIN-CONTAINING ADAPTER PROTEIN E; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 349..444
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 1..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..188
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..284
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 449 AA; 48711 MW; B5146517C9AEEA0B CRC64;
MAARWFKEFP LNLKTASERA RPGGGGGRLR KNSEAGGAGP APAKGRKNSA AELGSGRAGV
GAPRDSRPPR DSLQGLIQAA AGKSRKNSRA AEDEPPRGAA RSAGCGTYIS RLIKVDTQEK
NGRGSSSSSS SSSSSASSSP ASLGPELDKG RPGKQPDTVI ILEDYADPYD AKRTRGQRDA
ERAGENDGYM EPYDAQQMIT EIRRRGSKDP VVKALQLLDG PCESGENSAK AETAAKRRGS
KELVGKPPQL YDTPYEPPDG APERRARLPA EDERPAAEYE QPWEWKKEQL ARALSVQFEG
SDWPSVKEDP AKQQQRQKSW TQKVLKPVGP DHGEGEKVAP GLPLGKQPWY HGAITRAEAE
SRLQPCREAA YLVRNSESGN SKYSIALKTS QGCVHIIVAQ TKDSKYTLDQ TSAVFDSIPE
VVHYYSNEKL PFKGAEHMTL LYPVHSKGH
//
