ID M3YBU7_MUSPF Unreviewed; 457 AA.
AC M3YBU7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE RecName: Full=Glial fibrillary acidic protein {ECO:0000256|ARBA:ARBA00018571};
GN Name=GFAP {ECO:0000313|Ensembl:ENSMPUP00000008804.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000008804.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000008804.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- FUNCTION: GFAP, a class-III intermediate filament, is a cell-specific
CC marker that, during the development of the central nervous system,
CC distinguishes astrocytes from other glial cells.
CC {ECO:0000256|ARBA:ARBA00002194}.
CC -!- SUBUNIT: Interacts with SYNM. {ECO:0000256|ARBA:ARBA00024375}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; AEYP01079297; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3YBU7; -.
DR STRING; 9669.ENSMPUP00000008804; -.
DR Ensembl; ENSMPUT00000008948.1; ENSMPUP00000008804.1; ENSMPUG00000008874.1.
DR eggNOG; ENOG502RKU6; Eukaryota.
DR GeneTree; ENSGT00940000159539; -.
DR HOGENOM; CLU_012560_7_4_1; -.
DR InParanoid; M3YBU7; -.
DR OMA; IMAHQVH; -.
DR GO; GO:0097450; C:astrocyte end-foot; IEA:Ensembl.
DR GO; GO:0044297; C:cell body; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:Ensembl.
DR GO; GO:0014002; P:astrocyte development; IEA:Ensembl.
DR GO; GO:0060020; P:Bergmann glial cell differentiation; IEA:Ensembl.
DR GO; GO:0070779; P:D-aspartate import across plasma membrane; IEA:Ensembl.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0010467; P:gene expression; IEA:Ensembl.
DR GO; GO:0045109; P:intermediate filament organization; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IEA:Ensembl.
DR GO; GO:0060291; P:long-term synaptic potentiation; IEA:Ensembl.
DR GO; GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl.
DR GO; GO:0031102; P:neuron projection regeneration; IEA:Ensembl.
DR GO; GO:0010625; P:positive regulation of Schwann cell proliferation; IEA:Ensembl.
DR GO; GO:1904714; P:regulation of chaperone-mediated autophagy; IEA:Ensembl.
DR GO; GO:0051580; P:regulation of neurotransmitter uptake; IEA:Ensembl.
DR GO; GO:0014010; P:Schwann cell proliferation; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF9; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}.
FT DOMAIN 93..401
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 97..245
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 299..372
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 457 AA; 52295 MW; 67860C3C4BED7C74 CRC64;
LGSARPAHAS IKPSLPRSGQ SPASMERRRV ASAARRSYAS SLDMVGGSLV SGRRLGPGTR
LSLARMPLPL PARVDFSLAG ALNTGFKETR ASERAEMMEL NDRFASYIEK VRFLEQQNKA
LAAELNQLRA KEPTKLADVY QAELRELRLR LDQLTASSAR LEVERDNLAQ DLGTLRQKLQ
DETNLRLDAE NNLATYRQEA DEATLARLDL ERKIESLEEE IRFLRKIHEE EVQELQEQLA
RQQVHVELDV AKPDLTAALR EIRTQYEAMA SSNMHEAEEW YRSKFADLND AAARNAELLR
QAKHEANDYR RQLQALTCDL ESLRGTNESL ERQMREQEER HAREAASYQE ALARLEEEGQ
SLKDEMARHL QEYQDLLNIK LALDIEIATY RKLLEGEENR ITIPVQTFSN LQIRETSLDT
KSVSEGHLKR NIVVKTVEMR DGEQVIKESK QEHKDVM
//
