ID M3YCK7_MUSPF Unreviewed; 4997 AA.
AC M3YCK7;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000009064.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000009064.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
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DR EMBL; AEYP01067338; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01067339; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01067340; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01067341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01067342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01067343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01067344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01067345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01067346; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9669.ENSMPUP00000009064; -.
DR Ensembl; ENSMPUT00000009216.1; ENSMPUP00000009064.1; ENSMPUG00000009140.1.
DR eggNOG; KOG1808; Eukaryota.
DR GeneTree; ENSGT00550000074802; -.
DR HOGENOM; CLU_000050_0_0_1; -.
DR InParanoid; M3YCK7; -.
DR OMA; ILEQWHR; -.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd01460; vWA_midasin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR029317; KRBA1_rpt.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 7.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 2.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 1.
DR SMART; SM00382; AAA; 5.
DR SMART; SM01258; KRBA1; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 5.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340}.
FT DOMAIN 4785..4984
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 3927..3949
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4099..4662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4099..4146
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4155..4176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4177..4204
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4207..4296
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4297..4312
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4313..4347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4348..4366
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4367..4391
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4425..4439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4487..4505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4506..4531
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4587..4602
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4630..4662
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4997 AA; 565012 MW; 72B3A2FF1394FC80 CRC64;
MLSKHTSKLK MAEIIGSKLN ISKKKAEFFC QLYKPEIVIN ELDVQVGRVR LLRKQSEAVH
IQRERLTFAP TRPSSVLIEQ LAVCVSKGEP VLLVGETGTG KTSTVQYLAH ITGHRLRVVN
MNQQSDTADL LGGYKPVDHK LIWLPLRESF EELFAQTFSK KQNFTFLGHI QTCYRQKRWH
DLLRLMQHVH KSAVNKDGKE SETGLLLKEK WEAFGLRLNH AQQQMKMTEN ALLFAFVEGT
LAQAIKKGEW ILLDEINLAA PETLECLSGL LEGSYGSLVL LDRGDTEPLV RHPDFRLFAC
MNPATDVGKR NLPPGIRNRF TELYVEELES KEDLQILIVD YLKGLSVNKT TVQGIINLYT
ALRKDSGTKL VDGTGHRPHY SLRTLCRALR FAASNPCSNI QRSLYEGFCL GFLTQLDRAS
HPIVQKLICQ HVVSGNVKSL LKQPIPEPKG GRLIQVEGYW ISVGDKEPTI DETYVLTSSV
KLNLRDIVRV VSAGTYPVLI QGETSVGKTS LIRWLAAASG NHCVRINNHE HTDIQEYIGC
YTSDSSGKLV FKEGVLIDAM RKGYWIILDE LNLAPTDVLE ALNRLLDDNR ELLITETQEV
VKAHPRFMLF ATQNPPGLYG GRKVLSRAFR NRFVELHFDE LPSSELETIL HKRCSLPPSY
CSKLVKVMLD LQSYRRSSSV FAGKQGFITL RDLFRWAERY RLAEQTEKEY DWLQHLANDG
FMLLAGRVRK QEEIDVIQEV LEKHFKKKLC PQSLFSKENV LKLLSKLSTQ VSMLESTFSH
IVWTESMRRL AILVGRALEF GEPVLLVGDT GCGKTTICQV FAGLANQKLY SVNCHLHMET
SDFLGGLRPV RQKPKDKEEV DTSKLFEWHD GPLVLAMKED GFFLLDEISL ADDSVLERLN
SVLEMEKCLV LAEKGSVEDK DNEVELLTAG KKFRILATMN PGGDFGKKEL SPALRNRFTE
IWCPQSTNHE DLIQIISHNL RPGLSLGRVD HKGADIAEVM LDFIDWLTHQ EFGRRCVVSI
RDILSWVNFM NTMGEEAALK RPETISTVTS FVHAACLVYI DGIGSGATSS GFGTALLARK
ECLKFLLKKL CKIVRLTECQ KNELKIYDRL KAKEFTGIDN LWGIHPFFIP RGPVLHRNNV
ADYALSAGTT AMNAQRLLRA TKLNKPILLE GSPGVGKTSL VGALAKASGN ILVRINLSEQ
TDITDLFGAD LPVEGGKGGE FAWRDGPLLA ALKAGHWVVL DELNLASQSV LEGLNACFDH
RGEIYVPELG MSFQVQHEKT KIFGCQNPFR QGGGRKGLPR SFLNRFTQVF VDPLTVIDME
FIASTLFPAI DKNIVKKMVA FNNRIDHEVT IEKKWGQKGG PWEFNLRDLF RWCQLMLVDQ
SPGCYDPGQH VFLVYGERMR TKEDKEKVIA VFKDVFNSST NPYMGTRLFH ITPYDVQLGY
SVLSRGSYVP LLSCRPLSLL HQSLRSLESI MKCVQMSWMV ILVGPASVGK SSLVQLLAHL
TGHTLKIMAM NSAMDTTELL GGFEQVDLRR PWRQLLEKVE GTVRALLRDS LLISADDAEV
VLRAWSHFVL TYKPKCLGDG GKGITMEIVN KLEAVLLLMQ RLNNKINSYS KAEFAKLVEE
FRNFGVKLLQ STSGRSRGTF EWVDSMLVQA LKSGDWLLMD NVNFCNPSVL DRLNALLEPG
GVLTLSERGM IDGSTPTITP NPNFRLFLSM DPVHGEISRA MRNRGLEIYI SGEGDGNIPD
DLDMKVLLHS LGLVGDSVCN SLLALHTEIQ STVVGSPTSS ISTLIQTALL IVQYLQRGLS
LDRAFSEVCW EAYVRSQHSP ANQKLVQALL EKHVFSLRAH ETWGNSILAM GLWPDSLPSA
LFATEDSHLS VVRSDGQILV YCLNRMSMKT SSWARIQPLT LPDLEKIMQS SNPESLKFSS
VEVDTHWIDE PDVLAMAVKL LIEKATNQDW MLRVKWLYHL AKNIPQGLES IQIHLEASAA
SLRNFYSNSL SAGVSNVIKI LQPNITDEFV IPLDPRWNMQ ALDIIRNSVD FDPQTDQPEQ
LFALLESVAN KTILYLDREK RIFTEANLVS VGGKKLRNSV LRMSFEFHKD PESYHSLPPE
IVVNLAAFFE LCDALILLWV QSSQEIVSNA NVIEILDSLR WRDRFWTVAD TVKVDAPGLA
LLALHWHWVL KHLVLQIPQL LMNHEDKYYK EIQTVSEHIQ NCLGSPTGGF TGIKKLQKFL
GRPFPFKNKL VVECLSQLKV LHKALAIRER MSALGESGWW EDINRLQVVA SEWTLKKSLL
QAWGLVLKAN ILEDANPDEL KNIVNAHCSE LKAKGISLGF LEKKHNEASS LFQPDFTSLI
QLTRNVQLWP PMEYLAMLWQ YKVTADFMTQ ACLRRSSKNQ QPQIEEEIRH HITFCLKHTP
IAPQELRDLW FLLHHQKVST EEIISLWSDL FNSTFMSFWS STVTTNPEYW LMWSPLPGVE
QREMPKSLLD STLKGPGCLS RAVFSKCCFE VLTSSCRASP WDVSGFPILS SSHVTLGEWV
ERAVQLQDIS LALWTNMAVP SVAEFRRTDS QLQGLVLCRH LAGLAELLPE SRRQEYMQNC
EQLLLGDSQA FQIVGQTLGD MAGQEALPKE LLCLLLTSLR HLFGEGDSKQ DLPEPARRGS
LWVSLGLLQI QTWLPQARFD PAVKKEYKLK YAKEELHQLQ CEWKTRNLSS QLLTGTDLED
EVIFRHSHPH IRLLRQRIDH LENLICSLSK KQAFRPQVPA YESLVQEIHH YVTSIAKAPA
VQDLLTRLLQ ALRMDGPRSA QVAQNLLKEE ASWQQSHHQF RKRLAEDYAL YPDSVAPLQA
SILQLQHGMR LVASEVYASL HSSVVCADRL ATLASSLLAF PSVGPAFPTY YAHADTLCSV
KSEEVLRGLG KLILKRSGGK ELEGKGQRPF PTREQLLMNA LLYLRSHVLC KGELDQRALQ
LFRHVCQEII NEWDEQERIA QEKAEQENSL YRYRSRNSRT ALSEEEEEER EFRRQFPLHE
KDFADILVEP TLEEKKGTSD GQEEGAATDP TLFSQSSMQA VMLIHQQLCL NFARSLWYQQ
TLPPHETKHY LGLFLSCYQT GASLVTHFYP LMGAELNDQL LGSQLLACTL SNNTLFGEAV
SDLMVKPDGP YDFYQHPNVP EARHCQPVLQ GFSEAISQLL QEWPEHPALE QLLVVMDRIR
SFPLSSPISK FLNGLEILLA KAQDWEENAS RALSLRKHLD LVSQMIIRWR KLELNCWSMS
LDNTMKRHTE KSTKHWFSIY QMLEKHMQEQ TEEQEDDKQM TLMLLVSTLQ AFIEGSSLGE
FHVRLQMLLV FHCHVLLMPQ VEGKDSLCSV LWNLYHYYKQ FFDRVQAKIV ELRSPIEKEL
KEFVKISKWN DVSFWSIKQS VEKTHRTLFK FMKKFEAVLS EPCRSSLVES DKEEQPDFLS
QPTAISEASP IQSLNKTLRE TLLARPAAAQ AVIPEQSQSA PFPSEGELLR RLPKLMKRMR
KMCLTFMKES RLPHLVEGLD HFTGEVISCV SELQSLKVDP WAEKEKQRSE AKHILLRKQR
ALADLFQHLA KTGLSYRKGV SWARSKNPQE MLHLHPLDIR SALSIVSSTQ EADSRLLTEI
SSSWDGCQKY FFRSLARHAR LSAALAAPAK EMGMSNVERC KGFSAHLMKM LIRQRRSLTT
LTEQWVLLRN LLGCMQEIHG RLTGPLVYPV PFPPQDSVQQ WTERLQHLAM QSQILLEQLS
WFLQCCPNAG PTPGQREAQA QGQPSGAVQD LIPSELSYPS PVPRNQLPSG CRMRKQDQLW
QQSTARLTEM LKTIKTVKAD VDRIRQQSCE TLFHSWKDFE VCSSGLSCLS QMSVHLQGLE
SLFIIPGMEV EQTDQKMALV ESLEYLRGEI NKATDDFTTW KTHLLALGSQ SGNQMLEEGF
VEDFSEQVET AIRAILCAIQ NLAERNSKKT EESTDQTRPP EEDEAPGFER LQSGHLTKLL
EDDLWADVSA LHVQKIISAV SELLERLKSY GEDGTAAKHT FFSQSCCLLV RLVPMLSRYS
DLVLFFLTMS LATHRSTAKL LSVLAQVFTE LAQEGFCLPK EFMEDSAGEG ATEFHDYEGG
GIGEGEGMKD VSDQIENEEQ AEDTFQKGQE KDKDDPDSKS DIKGEDNAIE MSEDFEGKMH
DGELEEQEDD GKSDSEGGDL DKQMGDLNGE EADKLDERLW GDDEEEEDEE EEDSKTEETG
PGMDEEDCGL VAKDDNLDAG KSNRDKNQDK KEEREESEVA DDGQGQDKIN EQVDEREYDE
NEVDPYHGNQ EKLPEPEALD LPDDMNLDSE DKNGSEDTDH EEGEENPLEI EEKPMDTEEI
GHEAEEVKEE IEADHSEGQG QHEPEEDPSE EEKQEGEEEM DTGAEDQDKD TAEHPEENSE
DGRQSLEDED KEANEGSAED GIPVDQGLQP QEEEEGGENS DPDEQLPEAT ERKEHDSCGQ
TGLESVQSAQ AVELAGAAPE KEQGKEEHGS GAADANQAEG HESNFIARLA SQKQTKKNTQ
SFKRKPGQAD NERSVGDHSE HVHKRLRTVN MESHSEQGPA QPQAQLEDAD AFEHIKDGSD
PYDAQTYDVA SKEQQQSAKD SRGDQEEEIE DTFVDTEEEE LRAADVEQLK PEEVKSGTTA
SPGFDEMEVE TQAVKTEDQD PRTDLSHEET EKEKAERSRD STIHTAHQFL MDTVFQPFLK
DISELRQELE RQLEMWQPQE SENPEEEKAA AEMWQSYSAL TAPLSQQLCE QLRLILEPTQ
AAKLKGDYRT GKRLNMRKVI PYIASQFRKD KIWLRRTKPS KRQYQICLAI DDSSSMVDNH
TKQLAFESLA VIGNALTLLE VGQIAVCSFG ESVKLLHPFH EQFSDSSGSQ ILRLCKFQQK
KTKIAQFLEA VASMFAAAQQ PSQNAGPETA QLLLVVSDGR GLFLEGKDRV LAAVQAARNA
NIFVIFVVLD NPSSRDSILD IKVPIFKGPG EMPEIRSYME EFPFPFYIIL RDVNALPETL
SDALRQWFEL VAASDHP
//
