ID M3YLR2_MUSPF Unreviewed; 760 AA.
AC M3YLR2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=N-acetylated alpha-linked acidic dipeptidase like 1 {ECO:0000313|Ensembl:ENSMPUP00000012269.1};
GN Name=NAALADL1 {ECO:0000313|Ensembl:ENSMPUP00000012269.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000012269.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000012269.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane
CC protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR EMBL; AEYP01074236; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3YLR2; -.
DR STRING; 9669.ENSMPUP00000012269; -.
DR Ensembl; ENSMPUT00000012469.1; ENSMPUP00000012269.1; ENSMPUG00000012362.1.
DR eggNOG; KOG2195; Eukaryota.
DR GeneTree; ENSGT01030000234598; -.
DR HOGENOM; CLU_005688_3_2_1; -.
DR InParanoid; M3YLR2; -.
DR OMA; TEWMEEY; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:0043171; P:peptide catabolic process; IEA:Ensembl.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF50; AMINOPEPTIDASE NAALADL1; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 179..265
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 366..576
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 636..755
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
SQ SEQUENCE 760 AA; 82258 MW; 2C73DF9A262A7171 CRC64;
HPSIKSDPIL PRHCRMQWVK VLGGVVGAAA LLGLGIILGH FAIPKGANVP APSVSQDLDL
EILETVMQQL EASRIRENLR ELSREPHLAS SPRDEALVQL LLQRWQDPES GLDAAEAPAY
EVLLSFPSQE QPNHVAVVSP TGSVVFSCRQ SEQNLTGEQV GPDVVPPYAA YAPPGTPQGL
LVYANRGTEE DFMNLQTQGI KLEGTIALTR YGGAGRGAKA VNAAKYGVAG VLVYTDPADI
NDGQSSANET FPNSWCLPPS GVERGSYYEY FGDPLTPYLP ANPSSFRLDP DAAPGFPPIP
AQPIGFDDAK SLLCNLQGPV APAAWQGALG CDYRLGPGFR SDGDFPADSQ VNVSVHNRRE
LRNSSNVLGI IRGAVEPDRY VLYGNHRDSW VHGAVDPSSG TAVLLELSRV LGTLLKKGTW
RPRRSIVFAS WGAEEFGLIG STEFTEEFFS KLQERTVAYI NVDISVFANA TLRAQGTPPV
QSVIFAAAKQ VQIPAPSPVG LSIYDNWIRY SNRSSPAYGV VPSLGSLGAG SDYAPFIHFL
GISSMDIAYT YDRSKTSARI YPTYHTAFDT FGYVDKFVDP GFSSHQAVAR TAGSVLLRLS
DSLFLPLNVS DYGETLRSFL QAAQQHLGGL LEQHSISLGR LVTAVEKFEA AAKALEQHRS
ALQKGSPDPL QVRMLNDQLM LLERTFLNPR AFPEERYYSH VLWAPRTSSV ATFPGLANAC
SRAMNTSLGS EAWAEVRRQL SILVVALEGA AATLRPVADL
//
