ID M3YQW5_MUSPF Unreviewed; 727 AA.
AC M3YQW5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=E3 ubiquitin-protein ligase LRSAM1 isoform X1 {ECO:0000313|RefSeq:XP_004757323.1};
DE SubName: Full=Leucine rich repeat and sterile alpha motif containing 1 {ECO:0000313|Ensembl:ENSMPUP00000013724.1};
GN Name=LRSAM1 {ECO:0000313|Ensembl:ENSMPUP00000013724.1,
GN ECO:0000313|RefSeq:XP_004757323.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000013724.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000013724.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004757323.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004757323.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AEYP01042660; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01042661; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01042662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004757323.1; XM_004757266.3.
DR STRING; 9669.ENSMPUP00000013724; -.
DR Ensembl; ENSMPUT00000013941.1; ENSMPUP00000013724.1; ENSMPUG00000013827.1.
DR GeneID; 101678471; -.
DR KEGG; mpuf:101678471; -.
DR CTD; 90678; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00930000151044; -.
DR HOGENOM; CLU_022990_0_0_1; -.
DR OMA; DFWLLQY; -.
DR OrthoDB; 1043058at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0045806; P:negative regulation of endocytosis; IEA:Ensembl.
DR GO; GO:2000786; P:positive regulation of autophagosome assembly; IEA:Ensembl.
DR GO; GO:1904417; P:positive regulation of xenophagy; IEA:Ensembl.
DR GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
DR GO; GO:0030163; P:protein catabolic process; IEA:Ensembl.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:Ensembl.
DR GO; GO:0070086; P:ubiquitin-dependent endocytosis; IEA:Ensembl.
DR GO; GO:0046755; P:viral budding; IEA:Ensembl.
DR CDD; cd09523; SAM_TAL; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR48051; -; 1.
DR PANTHER; PTHR48051:SF46; LEUCINE RICH REPEAT AND STERILE ALPHA MOTIF CONTAINING 1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00364; LRR_BAC; 4.
DR SMART; SM00369; LRR_TYP; 4.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 565..632
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 680..715
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 221..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 314..376
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 515..546
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 727 AA; 83928 MW; 4E0A5ED67282667C CRC64;
MPLFFRKRKP SEEARKRLEY QMCLAKEAGA DDILDISKCE LSEIPYGAFA TCKVLQKKVL
IVHTNHLTSL LPKSCSLLSL ITIKVLDLHD NQLSALPDDI GQLTALQVLN MERNQLTYIP
RSIGNLIQLQ TLNVKDNKLK ELPDTVGELR SLRTLDISEN DIQKLPQLLA HVRTLETLSL
DTSSMVYPPQ EVCSAGTQAI QQFLCKESGL EYYPPSQYLL PVLEQDGGDT PRDSADGPSD
RLCREEVEWQ NRFSDYEKRK EQKMLEKLEF ERRLELGQRE HAQLLQQSNN QKDEILQTVK
EEQFRLEQGL SARQRYLDAE RQRLQEQLKQ TEQNISSRIQ KLLQENQRQK KSSEILKSLE
NERIRMEQLM SITQEETENL RRREIASAMQ QMLTESCKSR LVQMAYESQR QSLVQQACSS
MAEMDERFQQ ILSWQQMDQN KAISQILQES AMQKAAFEAL QVKKDLMHRQ IRNQIKLIET
ELLQLTQLEV KRKSLDTEAL QEVIAEQRWA LSSLLQQLLK EKTRREEELR EILTELEAKS
ETKQENYWLI QYQRLLNQKP LSLKLQEEGL ERQLAALLVD LSAEHYLPLF AHHRISLDTL
SRMSPADLAK VGVSEAGLQH EILRRVRELL AAARIRPELP NPPKGEALGA LEVPTAPEEL
PEPTTPSAPP VELEMPTSEC VVCLEREAQM IFLNCGHVCC CHQCCQPLRT CPLCRQEIAQ
CLRLYHS
//