ID M3YRK5_MUSPF Unreviewed; 430 AA.
AC M3YRK5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Homeobox D3 {ECO:0000313|Ensembl:ENSMPUP00000013964.1};
DE SubName: Full=Homeobox protein Hox-D3 {ECO:0000313|RefSeq:XP_004774456.1};
GN Name=HOXD3 {ECO:0000313|Ensembl:ENSMPUP00000013964.1,
GN ECO:0000313|RefSeq:XP_004774456.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000013964.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000013964.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004774456.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004774456.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC {ECO:0000256|ARBA:ARBA00003263}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family.
CC {ECO:0000256|ARBA:ARBA00009107}.
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DR EMBL; AEYP01083901; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004774456.1; XM_004774399.3.
DR STRING; 9669.ENSMPUP00000013964; -.
DR Ensembl; ENSMPUT00000014187.1; ENSMPUP00000013964.1; ENSMPUG00000014072.1.
DR GeneID; 101694201; -.
DR KEGG; mpuf:101694201; -.
DR CTD; 3232; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000160027; -.
DR HOGENOM; CLU_051508_1_0_1; -.
DR OMA; YPYGAAH; -.
DR OrthoDB; 728401at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0016235; C:aggresome; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IEA:Ensembl.
DR GO; GO:0021615; P:glossopharyngeal nerve morphogenesis; IEA:Ensembl.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR025281; DUF4074.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR45664:SF5; HOMEOBOX PROTEIN HOX-D3; 1.
DR PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1.
DR Pfam; PF13293; DUF4074; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 190..250
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 192..251
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 45..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 252..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..109
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..132
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..180
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 430 AA; 45457 MW; 8B8B5B2D69B6338C CRC64;
MLFELGQQAL ELPECTMQKA AYYENPGLFG GYGYSKETYG YGTPHQPYPP PAAASSLDTD
YPGSACSIQS SAPLRAPAHK GTELNGSCMR PGTGNSQGGG GGSQPPGLNS EQQPPQPPPP
PPTLPPSSPT NPGGGVPAKK AKGGPNASGS SATISKQIFP WMKESRQNSK QKNSCATAGE
SCEDKSPPGP ASKRVRTAYT SAQLVELEKE FHFNRYLCRP RRVEMANLLN LTERQIKIWF
QNRRMKYKKD QKAKGILHSP AGQSPERSPP LGSAAGHVAY SGQLPPVPGL AYDAPSPPAF
AKSQPNMYGL AAYTAPLSSC LPQQKRYAAP EFEPHPMASN GGGFASANLQ GSPVYVGGNF
VDSMAPASGP VFNLGHLSHP SSASVDYSCA AQIPGNHHHG PCDPHPTYTD LSAHHSSQGR
LPEAPKLTHL
//
