ID M3YS52_MUSPF Unreviewed; 594 AA.
AC M3YS52;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Solute carrier family 13 member 2 {ECO:0000313|Ensembl:ENSMPUP00000014162.1, ECO:0000313|RefSeq:XP_004747059.1};
GN Name=SLC13A2 {ECO:0000313|Ensembl:ENSMPUP00000014162.1,
GN ECO:0000313|RefSeq:XP_004747059.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000014162.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000014162.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004747059.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004747059.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC13A/DASS transporter (TC 2.A.47) family.
CC NADC subfamily. {ECO:0000256|ARBA:ARBA00006772}.
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DR EMBL; AEYP01021304; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01021305; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004747059.1; XM_004747002.3.
DR STRING; 9669.ENSMPUP00000014162; -.
DR Ensembl; ENSMPUT00000014388.1; ENSMPUP00000014162.1; ENSMPUG00000014270.1.
DR GeneID; 101688047; -.
DR KEGG; mpuf:101688047; -.
DR CTD; 9058; -.
DR eggNOG; KOG1281; Eukaryota.
DR GeneTree; ENSGT01030000234550; -.
DR HOGENOM; CLU_005170_9_1_1; -.
DR OMA; MLAINSW; -.
DR OrthoDB; 1359392at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0015139; F:alpha-ketoglutarate transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0015138; F:fumarate transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0017153; F:sodium:dicarboxylate symporter activity; IEA:Ensembl.
DR GO; GO:0015141; F:succinate transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0071285; P:cellular response to lithium ion; IEA:Ensembl.
DR CDD; cd01115; SLC13_permease; 1.
DR InterPro; IPR031312; Na/sul_symport_CS.
DR InterPro; IPR001898; SLC13A/DASS.
DR PANTHER; PTHR10283; SOLUTE CARRIER FAMILY 13 MEMBER; 1.
DR PANTHER; PTHR10283:SF137; SOLUTE CARRIER FAMILY 13 MEMBER 2; 1.
DR Pfam; PF00939; Na_sulph_symp; 1.
DR PROSITE; PS01271; NA_SULFATE; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Sodium {ECO:0000256|ARBA:ARBA00023201};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 43..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 87..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 117..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 509..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 543..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 162..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 594 AA; 64739 MW; 5E149A70CE5A5A56 CRC64;
MATCWQGLWA YRSYLLVFFL PILLLPLPIF IPTKEASCAY SIIIMALFWC TEALPLAVTA
LFPIFLYPLM GIMDASEVCL EYFKDSNILF VGGLLVAIAV EHWNLHKRIA LRVLLIIGVR
PALLLLGFML VTAFLSMWIS NTATTAMMVP IAHAVLDQLH QSPTGKDAEK GSNNPAFELQ
EPGPQKKVTK FDEKDNGQVH PIPAASLEPT TQPQEQVRFS QGMSLCVCYA ASIGGIATLT
GTTPNLVLQG QVNSLFPKNG NVVNFASWFG FAFPTMVILL VLSWLWLQIL FLGFNFRKNF
GFGEQAQERA QAAFRVIQTE HKLLGPMSFA EKAVSVLFVT LVVLWFTREP GFFLGWGNLA
FSDKDGNSMA SDGTVAIFIG VILFLVPSKI PGLTQDPENP GRLKAPPALL NWKTVNEKMP
WNIVLLLGGG FALAKGSEQS GLSEWLGKKL TPLENVPPPA IALIISLLVA TFTECTSNVA
TTTLFLPILA SMAQAICLHP LYVMLPCTLA ASLAFMLPVA TPPNAIVFSF GGLKVSDMAR
TGFLLNIIGV LIITLAINSW SYPIFNLHTF PSWADTNNTA SCLAIQGNIT TPSP
//
