ID M3YYW2_MUSPF Unreviewed; 422 AA.
AC M3YYW2;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Desmin {ECO:0000256|ARBA:ARBA00040601};
GN Name=DES {ECO:0000313|Ensembl:ENSMPUP00000016522.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000016522.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000016522.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma
CC {ECO:0000256|ARBA:ARBA00004135}. Cytoplasm, myofibril, sarcomere, Z
CC line {ECO:0000256|ARBA:ARBA00004216}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; AEYP01056844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01056845; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3YYW2; -.
DR STRING; 9669.ENSMPUP00000016522; -.
DR Ensembl; ENSMPUT00000016768.1; ENSMPUP00000016522.1; ENSMPUG00000016625.1.
DR eggNOG; KOG0977; Eukaryota.
DR GeneTree; ENSGT00940000155522; -.
DR HOGENOM; CLU_012560_7_4_1; -.
DR InParanoid; M3YYW2; -.
DR OMA; QGANASC; -.
DR GO; GO:0097512; C:cardiac myofibril; IEA:Ensembl.
DR GO; GO:0005916; C:fascia adherens; IEA:Ensembl.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR GO; GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0045109; P:intermediate filament organization; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR PANTHER; PTHR45652:SF2; DESMIN; 1.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Muscle protein {ECO:0000256|ARBA:ARBA00023179}.
FT DOMAIN 60..368
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 57..219
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 252..346
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 422 AA; 48668 MW; 215CAC50F31A614F CRC64;
MMSRVYQVSR TSGGAGGLGA LRASRLGSAR APSSYGAGEL LDFSLADAVN QEFLTTRTNE
KVELQELNDR FANYIEKVRF LEQQNAALAA EVNRLKGREP TRVAEIYEEE LRELRRQVEV
LTNQRARVDV ERDNLLDDLQ RLKAKLQEEI QLREEAENNL AAFRADVDAA TLARIDLERR
IESLNEEIVF LKKVHEEEIR ELQAQLQEQQ VQVEMDMSKP DLTAALRDIR AQYETIAAKN
ISEAEEWYKS KVSDLTQAAN KNNDALRQAK QEMMEYRHQI QSYTCEIDAL KGTNDSLMRQ
MREMEDRFAS EASGYQDNIA RLEEEIRHLK DEMARHLREY QDLLNVKMAL DVEIATYRKL
LEGEESRINL PIQTFSALNF RETSPEQRGS EVHTKKTVMI KTIETRDGEV VSEATQQQHE
VL
//
