ID M3YZL6_MUSPF Unreviewed; 583 AA.
AC M3YZL6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=PX domain containing serine/threonine kinase like {ECO:0000313|Ensembl:ENSMPUP00000016776.1};
GN Name=PXK {ECO:0000313|Ensembl:ENSMPUP00000016776.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000016776.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000016776.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
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DR EMBL; AEYP01002193; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01002194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01002195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01002196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01002197; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AEYP01002198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M3YZL6; -.
DR STRING; 9669.ENSMPUP00000016776; -.
DR Ensembl; ENSMPUT00000017025.1; ENSMPUP00000016776.1; ENSMPUG00000016881.1.
DR eggNOG; KOG2101; Eukaryota.
DR GeneTree; ENSGT00390000017669; -.
DR HOGENOM; CLU_036868_0_0_1; -.
DR InParanoid; M3YZL6; -.
DR OMA; FTQYAST; -.
DR GO; GO:0034451; C:centriolar satellite; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:Ensembl.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IEA:Ensembl.
DR CDD; cd06871; PX_MONaKA; 1.
DR CDD; cd22062; WH2_DdVASP-like; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR037903; MONaKA_PX.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR22999:SF40; PX DOMAIN-CONTAINING PROTEIN KINASE-LIKE PROTEIN; 1.
DR PANTHER; PTHR22999; PX SERINE/THREONINE KINASE PXK; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02205; WH2; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
FT DOMAIN 11..123
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT DOMAIN 85..480
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 553..572
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 436..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..459
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..507
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..535
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 583 AA; 65361 MW; B0B4AB8B6FAEB43B CRC64;
MEKPPAGKVL LDDTVPLTAA IEASQSLQSH TEYIIRVQRG ISAENSWQIV RRYSDFDLLN
NSLQIAGLSL PLPPKKLIGN MDREFIAERQ KGLQNYLNVI TTNHILSNCE LVKKFLDPNN
YSANYTEIAL QQVSMFFRSE PKWEVVEPLK DIGWRIRKKY FLMKIKNQPK ERLVLSWADL
GPDKFLSDKD FQCLIKLLPS CSHPYIYRVT FATANESSAL LIRMFNEKGT LKDLIYKAKP
KDPFLKKYCN PKKIQGLELQ QIKTYGRQIL EVLKFLHDKG FPYGHLHASN VMLDGDTCRL
LDLENSLLGL PSFYRSYFSQ FRKINTLESV DVHCFGHLLY EMTYGRPPDS VPVDSFPPAP
SMAVVQVAVL ESTLSCEACK NGMPAVSRLL QMPLFSDVLL TTSEKPQFKI PTKLKEALRI
AKECIEKRLI EEQKQIHQHR RLTRAQSHHG SEEERKKRKI LARKKSKRSA VENSEEHSAK
YSNSNNSAGS GASSPLTSPS SPTPPSTAAG LGLRMSALPP PPPPPPPPPA APLLPASTEA
PTQLLPQAVN GVSRGALLSS IQNFQKGTLR KAETCDHSAP KIG
//
