ID M3Z5N4_MUSPF Unreviewed; 355 AA.
AC M3Z5N4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=C-C chemokine receptor type 8 {ECO:0000313|RefSeq:XP_004759371.1};
DE SubName: Full=C-C motif chemokine receptor 8 {ECO:0000313|Ensembl:ENSMPUP00000018896.1};
GN Name=CCR8 {ECO:0000313|Ensembl:ENSMPUP00000018896.1,
GN ECO:0000313|RefSeq:XP_004759371.1};
OS Mustela putorius furo (European domestic ferret) (Mustela furo).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Musteloidea; Mustelidae;
OC Mustelinae; Mustela.
OX NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000018896.1};
RN [1] {ECO:0000313|Ensembl:ENSMPUP00000018896.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAR-2023) to UniProtKB.
RN [2] {ECO:0000313|RefSeq:XP_004759371.1}
RP IDENTIFICATION.
RC TISSUE=Brain {ECO:0000313|RefSeq:XP_004759371.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; AEYP01049029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004759371.1; XM_004759314.3.
DR RefSeq; XP_012915320.1; XM_013059866.1.
DR STRING; 9669.ENSMPUP00000018896; -.
DR Ensembl; ENSMPUT00000019170.1; ENSMPUP00000018896.1; ENSMPUG00000019018.1.
DR GeneID; 101675232; -.
DR KEGG; mpuf:101675232; -.
DR CTD; 1237; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01020000230359; -.
DR HOGENOM; CLU_009579_8_3_1; -.
DR OMA; QLDQWVF; -.
DR OrthoDB; 4604454at2759; -.
DR Proteomes; UP000000715; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016493; F:C-C chemokine receptor activity; IEA:Ensembl.
DR GO; GO:0006935; P:chemotaxis; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR004068; Chemokine_CCR8.
DR InterPro; IPR000355; Chemokine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR10489:SF627; C-C CHEMOKINE RECEPTOR TYPE 8; 1.
DR PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00657; CCCHEMOKINER.
DR PRINTS; PR01530; CHEMOKINER8.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040,
KW ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688,
KW ECO:0000313|RefSeq:XP_004759371.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000715};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 36..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 73..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 111..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..264
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 52..300
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 335..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..355
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 355 AA; 40597 MW; 50E3CC46AC5631E8 CRC64;
MDYTLEPNVT TVTDYYYPDT MSSPCDGELI QRDSKLLLAV FYCVLFVFGL LGNILVILVL
VACKKLRSIT DVYLLNLVLS DLLFVFSFPF QTHYQLDQWV FGTVMCKVVS GFYYIGFFSS
MFFITLMSVD RYLAIVHAVY AMKVRTARMG TALSLAVWLI AIMATSPLLV VYQVASEDGI
LQCYSSYNQQ TLKWKIFIHF EMNILGLLIP FTILMFCYIS ILHQLKSCQN HNKTKAIKLV
LIVVIASLLF WVPFNVVLFL TSLLNMNILD GCVLSQRLIY ATHVTETISF THCCVNPVIY
AFMGEKFKKH LSEIFQKISN YGLLFVGRQI PREGWEKPPS SCQHPSRSSS TDYIL
//
