UniProt: M3ZA84

Database: UniProt
Entry: M3ZA84_NOMLE

LinkDB:  M3ZA84_NOMLE 
Original site:  M3ZA84_NOMLE

All links

Ontology (5)   
   GO (5)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (3)   
   ENSEMBL-UP (3)   
DNA sequence (8)   
   EMBL (8)   
Protein domain (13)   
   InterPro (9)   
   Pfam (3)   
   PROSITE (1)   
All databases (30)   

Download RDF

ID   M3ZA84_NOMLE            Unreviewed;      1226 AA.
AC   M3ZA84;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   27-MAR-2024, entry version 49.
DE   RecName: Full=isoleucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013165};
DE            EC=6.1.1.5 {ECO:0000256|ARBA:ARBA00013165};
DE   AltName: Full=Isoleucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00032665};
GN   Name=IARS1 {ECO:0000313|Ensembl:ENSNLEP00000023621.2};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000023621.2, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000023621.2, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000023621.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-
CC         isoleucyl-tRNA(Ile); Xref=Rhea:RHEA:11060, Rhea:RHEA-COMP:9666,
CC         Rhea:RHEA-COMP:9695, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58045, ChEBI:CHEBI:78442, ChEBI:CHEBI:78528,
CC         ChEBI:CHEBI:456215; EC=6.1.1.5;
CC         Evidence={ECO:0000256|ARBA:ARBA00000114};
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ADFV01190162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01190163; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01190164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01190165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01190166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01190167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01190168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01190169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; M3ZA84; -.
DR   Ensembl; ENSNLET00000032351.2; ENSNLEP00000023621.2; ENSNLEG00000016253.3.
DR   GeneTree; ENSGT00550000074921; -.
DR   HOGENOM; CLU_001493_1_0_1; -.
DR   Proteomes; UP000001073; Chromosome 1a.
DR   GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004822; F:isoleucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000049; F:tRNA binding; IEA:InterPro.
DR   GO; GO:0006428; P:isoleucyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd07961; Anticodon_Ia_Ile_ABEc; 1.
DR   CDD; cd00818; IleRS_core; 1.
DR   Gene3D; 3.40.50.620; HUPs; 2.
DR   HAMAP; MF_02003; Ile_tRNA_synth_type2; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR002300; aa-tRNA-synth_Ia.
DR   InterPro; IPR033709; Anticodon_Ile_ABEc.
DR   InterPro; IPR002301; Ile-tRNA-ligase.
DR   InterPro; IPR023586; Ile-tRNA-ligase_type2.
DR   InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR   NCBIfam; TIGR00392; ileS; 1.
DR   PANTHER; PTHR42780:SF1; ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC; 1.
DR   PANTHER; PTHR42780; SOLEUCYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF08264; Anticodon_1; 1.
DR   Pfam; PF19302; DUF5915; 1.
DR   Pfam; PF00133; tRNA-synt_1; 1.
DR   PRINTS; PR00984; TRNASYNTHILE.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363035};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363035};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363035};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT   DOMAIN          17..618
FT                   /note="Aminoacyl-tRNA synthetase class Ia"
FT                   /evidence="ECO:0000259|Pfam:PF00133"
FT   DOMAIN          673..829
FT                   /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT                   anticodon-binding"
FT                   /evidence="ECO:0000259|Pfam:PF08264"
SQ   SEQUENCE   1226 AA;  140050 MW;  382E3E8BD043F35B CRC64;
     MVQQVPENIN FPAEEEKILE FWTEFNCFHE CLKQSKHKPK FTFYDGPPFA TGLPHYGHIL
     AGTIKDIVTR YAHQSGFHVD RRFGWDCHGL PVEYEIDKTL GIRGPEDVAR MGITEYNNQC
     RAIVMRYSAE WKSTVSRLGR WIDFDNDYKT LYPEFMESVW WVFKQLYDKG LVYRGVKVMP
     FSTACNTPLS NFESHQNYKD VQDPSVFVTF PLEEDETISL VAWTTTPWTL PSNLAVCVNP
     EMQYVKIKDV ARGRLLILME ARLSLLCVCV HPAVLSFQCK ENGAFTVLVD DYVKEEEGTG
     VVHQAPYFGA DDYRVCMDFN IIRKDSLPVC PVDASGCFTA EVTDFAGQYV KDADKSIIRT
     LKEQGRLLVA TTFTHSYPFC WRSDTPLIYK AVPSWFVRVE NMVDQLLRNN DLCYWVPELV
     REKRFGNWLK DARDWTISRN RYWGTPIPLW VSDDFEEVVC VGSVAELEEL SGAKISDLHR
     ESVDHLTIPS RCGKGSLHRI SEVFDCWFES GSMPYAQVHY PFENKREFED AFPADFIAEG
     IDQTRGWFYT LLVLATALFG QPPFKNVIVN GLVLASDGQK MSKRKKNYPD PVSVIQKYGA
     DALRLYLINS PVVRAENLRF KEEGVRDVLK DVLLPWYNAY RFLIQNVLRL QKEEEIEFLY
     NENTVRESPN ITDRWILSFM QSLIGFFETE MAAYRLYTVV PRLVKFVDIL TNWYVRMNRR
     RLKGENGMED CVMALETLFS VLLSLCRLMA PYTPFLTELM YQNLKVLIDP VSVQDKDTLS
     IHYLMLPRVR EELIDKKTES AVSQMQSVIE LGRVIRDRKT IPIKYPLKEI VVIHQDPEAL
     KDIKSLEKYI IEELNVRKVT LSTDKNKYGI RLRAEPDHMV LGKRLKGAFK AVMTSIKQLS
     SEELEQFQKT GTIVVEGHEL HDEDIRLMYT FDQATGGTAQ FEAHSDAQAL VLLDVTPDQS
     MVDEGMAREV INRIQKLRKK CSLVPTDEIT VYYKAKSEGT YLNNVIESHT EFIFATIKAP
     LKPYPVSPSD KILIQEKTQL KGSELEITLT RGSSLPGPAC AYVNLNICAN GSEQGGVLLL
     ENPKGDNRLD LLKLKSVVTS IFGVKNTELA VFHDETEIQN QSDLLSLSGK TLCVTAGSAP
     PLINSSSTLL CQYINLQLLN AEPQECLMGT VGTLLLENPL GQNGLTHQGL LYEAAKVFGL
     RSRKLKLFLN ETQTQDFPLS FTFCSL
//

DBGET integrated database retrieval system