UniProt: M3ZC92

Database: UniProt
Entry: M3ZC92_NOMLE

LinkDB:  M3ZC92_NOMLE 
Original site:  M3ZC92_NOMLE

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Ontology (4)   
   GO (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (3)   
   ENSEMBL-UP (3)   
DNA sequence (10)   
   EMBL (10)   
Protein domain (9)   
   InterPro (6)   
   Pfam (2)   
   PROSITE (1)   
All databases (27)   

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ID   M3ZC92_NOMLE            Unreviewed;       666 AA.
AC   M3ZC92;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   27-MAR-2024, entry version 56.
DE   RecName: Full=Acetoacetyl-CoA synthetase {ECO:0000256|ARBA:ARBA00015326, ECO:0000256|RuleBase:RU367019};
DE            EC=6.2.1.16 {ECO:0000256|ARBA:ARBA00012988, ECO:0000256|RuleBase:RU367019};
GN   Name=AACS {ECO:0000313|Ensembl:ENSNLEP00000024329.2};
OS   Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae;
OC   Nomascus.
OX   NCBI_TaxID=61853 {ECO:0000313|Ensembl:ENSNLEP00000024329.2, ECO:0000313|Proteomes:UP000001073};
RN   [1] {ECO:0000313|Ensembl:ENSNLEP00000024329.2, ECO:0000313|Proteomes:UP000001073}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Gibbon Genome Sequencing Consortium;
RL   Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSNLEP00000024329.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Converts acetoacetate to acetoacetyl-CoA in the cytosol.
CC       {ECO:0000256|RuleBase:RU367019}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP +
CC         diphosphate; Xref=Rhea:RHEA:16117, ChEBI:CHEBI:13705,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57286,
CC         ChEBI:CHEBI:57287, ChEBI:CHEBI:456215; EC=6.2.1.16;
CC         Evidence={ECO:0000256|RuleBase:RU367019};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|RuleBase:RU367019}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432, ECO:0000256|RuleBase:RU367019}.
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DR   EMBL; ADFV01093777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01093778; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01093779; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01093780; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01093781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01093782; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01093783; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01093784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01093785; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ADFV01093786; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; M3ZC92; -.
DR   Ensembl; ENSNLET00000032693.2; ENSNLEP00000024329.2; ENSNLEG00000002559.3.
DR   GeneTree; ENSGT00940000156044; -.
DR   HOGENOM; CLU_000022_3_3_1; -.
DR   Proteomes; UP000001073; Chromosome 10.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd05943; AACS; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR005914; Acac_CoA_synth.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR   PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR   PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU367019};
KW   Cytoplasm {ECO:0000256|RuleBase:RU367019};
KW   Fatty acid metabolism {ECO:0000256|RuleBase:RU367019};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU367019};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW   ECO:0000256|RuleBase:RU367019};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU367019};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001073}.
FT   DOMAIN          47..104
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          110..488
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
SQ   SEQUENCE   666 AA;  74263 MW;  D65793148F098AF7 CRC64;
     MSKEGRPGPE EILECQVMWE PDSKKNTQMD RFRAAVGAAC GLALENYDDL YHWSVESYSD
     FWAEFWKFSG IVFSRVYDEV VDTSKGIADV PEWFKGSRLN YAENLLRHKE NDRVALYVAR
     EGKEEIVKVT FEELRQEVAL FAAAMRKMGV KKGDRVVGYL PNSEHAVEAM LAAASIGAIW
     SSTSPDFGVN GVLDRFSQIQ PKLIFSVEAV VYNGKEHNHM EKLQQVVKGL PDLKKVVVIP
     YVSSRENIDL SKIPNSVFLD DFLATGTSEQ APQLEFEQLP FSHPLFIMFS SGTTGAPKCM
     VHSAGGTLIQ HLKEHLLHGN MTSSDILLCY TTAGWMMWNW MVSILATGAA IVLYDGSPLV
     PTPNVLWDLV DRIGITVLVT GAKWLSVLEE KAMKPVETHS LQMLHTILST GSPLKAQSYE
     YVYRCVKSSI LLGSISGGTD IISCFMGHNF SLPVYKGEIQ ARNLGMAVEA WNEEGKAVWG
     ESGELVCTKP IPCQPTHFWN DENGNKYRKA YFSKFPGIWA HGDYCRINPK TGGIIMLGRR
     GPLRECAPSP VSTVESFEEV EDSLCVPQYN KYREERVVLF LKMASGHAFQ PDLVKRIRDA
     IRVGLSARHV PSLILETKGI PYTLNGKKVE VAVKQIIAGK AVEQGGAFSN PETLDLYRDI
     PELQGF
//

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