ID M3ZF31_XIPMA Unreviewed; 662 AA.
AC M3ZF31;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=RalA binding protein 1 {ECO:0000313|Ensembl:ENSXMAP00000000823.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000000823.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000000823.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000000823.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005802024.1; XM_005801967.2.
DR AlphaFoldDB; M3ZF31; -.
DR STRING; 8083.ENSXMAP00000000823; -.
DR Ensembl; ENSXMAT00000000826.2; ENSXMAP00000000823.1; ENSXMAG00000000825.2.
DR GeneID; 102225360; -.
DR KEGG; xma:102225360; -.
DR CTD; 10928; -.
DR eggNOG; KOG4370; Eukaryota.
DR GeneTree; ENSGT00940000154639; -.
DR HOGENOM; CLU_028068_1_0_1; -.
DR InParanoid; M3ZF31; -.
DR OMA; LMHYKRL; -.
DR OrthoDB; 24414at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd04381; RhoGap_RalBP1; 1.
DR Gene3D; 1.20.58.90; -; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR039767; RALBP1.
DR InterPro; IPR049041; RalBP1-like_Ral-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR12783; RALA BINDING PROTEIN 1 RALBP1; 1.
DR PANTHER; PTHR12783:SF5; RALA-BINDING PROTEIN 1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF20924; RLIP76_Ral-bd; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 185..373
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 662 AA; 75654 MW; 014C4242F97F63BF CRC64;
MTECFLPPSS SPAEQRRADH PGGVARTPSS EEISPTKFPG LYRTGEPSPP HDGHHHEPPD
PYVSDDDKEH SKKKNKFKKK EKRTEGYAAF QEDSSADEAE SPSKMKRSKG IHVFKKPSFS
KKKEKDFKVK EKGPKEDKAK EKKSKDLTAA DVVKQWKEKK KKKKPASEAE PVPVETPTVR
PIFGAPLAEA VKRTALYDGI QLPAIFRECV DYIENYGMKC EGIYRVSGMK SKVDELKAAY
DREECPCLEE YDPHTVASLL KQYLRELPEN LLGRDLTQRF EDACGRPAEA DKLAEFHKLL
AEVPADTRLL LSWLVTHMDH VIARETDTKM NIQNISIVLN PTIQIGNRVL YIFFTHVKEL
FGDVVLKPVV RPLRWSNMAT MPALPETQDN IKEEIRRQEF LLNCLHRDLQ AGVKDLSKEE
RLWEVQRILT ALKRKLREAK RQECESKIAQ EIASLSKEDV SKEEMTENEE EVINLLLAQE
NEILTEQEEL IALEQVLRRQ IATEKEEIER LRAEIADIQS RQQGRSETEE YSSDSESESE
DEEELQMILE DLQKQNEELE NKNTHLNQAI HEEQEAILEL RVQLRLLQSH KQQQQQQELP
VPPPAEQAPP TQPSPEARSE EQTKRSISTV AATGDAPAPT NGKPLKDPSK PSPSKDRRDT
NM
//
