ID M3ZGP8_XIPMA Unreviewed; 1395 AA.
AC M3ZGP8;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Early endosome antigen 1 {ECO:0000313|Ensembl:ENSXMAP00000001390.2};
GN Name=EEA1 {ECO:0000313|Ensembl:ENSXMAP00000001390.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000001390.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000001390.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000001390.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSXMAT00000001393.2; ENSXMAP00000001390.2; ENSXMAG00000001366.2.
DR eggNOG; ENOG502QWB5; Eukaryota.
DR GeneTree; ENSGT00940000156910; -.
DR HOGENOM; CLU_256550_0_0_1; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15730; FYVE_EEA1; 1.
DR Gene3D; 1.10.287.1490; -; 3.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR013087; Znf_C2H2_type.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23164; EARLY ENDOSOME ANTIGEN 1; 1.
DR PANTHER; PTHR23164:SF17; EARLY ENDOSOME ANTIGEN 1; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF69979; Eea1 homodimerisation domain; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 36..65
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1336..1394
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 307..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 569..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 823..938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 973..1047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1098..1129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1220..1324
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 744..776
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 857..911
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 912..927
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 985..1024
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1025..1041
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1098..1119
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1395 AA; 158953 MW; 225101801D00F4F3 CRC64;
MFRRILQMTP GKGGSQNAES EKPTTDLNHD QTSEGFICPQ CMKSHNSADE LFKHYELFHD
TGDLPAHVAP TREDLTMLRQ EVQDLHASLK EERWFSGELK KELDKVQGQL KQNDGPISAE
DSALERKLVE AETEKFNIKQ MKDLFEQKAA QLATEIVDLK SRYDEEKSLR EAANQRVSSL
SEQLQREKQE NERLQTELLQ RPGVEDVEVL QKELVQVQTL MDRMTREQEE ESERLKSHYT
ELQANYTTSE MTISQLKAEL EKGPQEAAVY TQQIHELQGN LNNLQQQCQS LSEKLVRKEK
ELQEVGDTLG AEKAAKKGVQ DSLRERDSEV QELQARAAGA EASLQKAQAE LEERAEEAAK
LRSEIVELEV KHAELKVERK QLEHQREEKE SQGAQQQTEI SQLHAKLLEA ERQVGELQGR
LKEQRQLSGE KLKDREQQAA DLQFKLSRTE EQVKENCSKN SDLQHQLEKA KQQHQELQAL
QQNTNGKLRE AQNDLEQVLR QIGDKDQKIQ NLEALLQKSK DTVSQLEAER EDLCAKIQAG
EGETALLNQL KEKNHALHEQ VAQLTDKLKN QSESNKQAQD NLHKQVQEQK TQLRSAQDRA
QTLETSVTEL TAQLTDSKEK VSQLDAQLKA KTELLLSAEA AKAAQKANLE NSLEASQHAL
QDKQQELSEA QKRLEDQAQR LRDRQEQSAQ LESSLKECKD KLLASEQRVE QLEGLSKKLE
SQAAEVQTAR DQLQLEVQKL QKESSEVKRK AKELQRSLET EKEGTKSLHE ELQKKAAAEG
GLQQHLERCE QEMAALKVNL NKVTQEGQSQ QAELSKKTQS LAAELQKAQQ EKEAQRKELG
AAQESLQKAN KALKESQNQL EVDRKNHKSA MEDKDKSIEK TRKELLKTNE AITKKMNESK
EQLEQSREAE KTLKAQLTSF EQQHSKTQGT LKGKEEEFKK LQDQLKTVRG SMEEEAKRLS
SQVAELQEAA VKKAEEERKL ATRVSELSQD LTAERSRAAE LQQSLQQSQE NLSKLQSDFY
GKDSEVSSLR QDLKSSEEKL SMAQEELAAN RTHQTALEAQ IQELKAARST LEQELSKRHQ
KLQQQEQALK ELQKQEGQVK EELQKERSKA EELSKAKSAL EKNSSKLTSD LKTLAEKSEK
ELGELQEAKQ LLIQQKLELQ GQVEAVQGAL KEEKKEHQVT KDNRSKREEQ LLVQTKEVQD
QLAAERRARE EQVKLGEEAE AKLSVQVTAL NENVATLKRE WQSSQRRVGE LEKQTDELRG
EIAVLEATVQ NNQDERRALL ERCVAGEGEI EKLQAKVVEL RRKLDDTTAA MQELGRENQS
LQIKQSQSLT RKWAEDHEVQ NCMACGKGFT VTVRKHHCRH CGNIFCGECS ARSALTPSSK
KPVRVCETCF EELQG
//