ID M3ZI50_XIPMA Unreviewed; 2175 AA.
AC M3ZI50;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Retinal-specific ATP-binding cassette transporter-like {ECO:0000313|Ensembl:ENSXMAP00000001892.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000001892.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000001892.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000001892.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 8083.ENSXMAP00000001892; -.
DR Ensembl; ENSXMAT00000001897.2; ENSXMAP00000001892.2; ENSXMAG00000001854.2.
DR eggNOG; KOG0059; Eukaryota.
DR GeneTree; ENSGT00940000155624; -.
DR HOGENOM; CLU_000604_19_0_1; -.
DR InParanoid; M3ZI50; -.
DR OMA; RDELTQN; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR PANTHER; PTHR19229:SF190; RETINAL-SPECIFIC PHOSPHOLIPID-TRANSPORTING ATPASE ABCA4; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 647..667
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 687..711
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 723..746
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 752..772
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1286..1304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1316..1337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1573..1595
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1625..1642
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1654..1672
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1684..1709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1767..1789
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 904..1135
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1831..2063
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 2175 AA; 247506 MW; 97906E3AADE32C8C CRC64;
MGSGGQVRLL LWKNWTIRRR QRIRFFMEIM WPVMLFMGLV WLRRVNPLYR QHECHFPNKA
MPSAGILPWI QGIVCNANNP CFQYPTRGES PGLVSNYNNS ILARFYSDAE ELLFSDPEFL
QVGRLWRELN AMSNFMDTLR THPKKVSGRG VKVEAILKDD ETLTSFLLRD IPLTESVVDH
LVNAQIRPEQ FAFGVPDLHL KDIACSLSLL ERFLIFQSHR GLYSVRNAMC ILTPQRLQII
EDRFYANVDF FKLFRLVSLP RVLDNYSDGI DIHFWVRIVS TASDRLSMEF IQVVTPLFQK
NLSFREVMAA ASSLVCGYTE GAFSRVASFN WYEDNNYKVF LGISSDWAQA DYTYDNTTTP
FCNDLMKELE FNPATRIVWN SVKPMLMGRI LYAPDSPAVK QIIRNANTTF EELERLRTMG
KAWEEVAPQI WAFFQDGVQV KMIRDTIRNP SVMDFIDRSL EEAPFSSEHI LNFLHNGPPE
ERRYDMPNFD WRDIFNLTDR VIRMLNQYGD CLILDKFIPL PDEDAVTHRA LDLLEGGTFW
AGLVFTNMFS WTTSVPPHVK FKIRMDIDIV ERTNKVKDRY WDPGPRADPM DDFRYIWGGF
AYLQDIIEHG IIRTHTGKEW PLGVYLQQFP YPCYVDDLFM LTLNRCFPIF MVLAWVYSVS
MVVKSIVLEK ELRLKETLKT IGVTNGVIWS TWFIDSFFMM GTSTALLTAI IMGGRVLNYS
DPVILFLFLL SFTTATIMQC FLFSVFFNQA NLAAACCGII YFTLYLPHIF CFAWQERITK
DMKIMAVGSL LSQVAFGFGT EYLSRYEEQG MGLQWDNIQT SPLEGDEFSF LTSICMMGLD
TVLYAALAWY LDNVFPGQYG IGRPFYFPLL PCYWLNNGGK TELFLVSTEE PFFEAEPADL
VKGVCIQNLV KVFSNCSSPA VDGLSINFYE SQITAFLGHN GAGKTTTMSV LTGMFPPTSG
TATIYGKDIR SDMDSIRMSL GMCPQYNILF QHMTVAEHIL FYTLLKGRPI AEAEEEVENM
LQDLGLPHKR DELTQNLSGG MQRKLSVALA FVGGAKVVIL DEPTSGVDPY SRRSIWDLLL
KYRLGRTVIM STHHMDEADL LSDRVAIISQ GRLYCCGSPI FLKNCFGAGF YLTLVRRMKH
EPPNVRNWEN ETFSNQEESQ TPDRQLDGNM ESITALVHHH VPQACLIEAI GQELTFLLPN
RDFQPRAYAS LFRELEETLV DIGLSSFGVS DTSLEEVEIN VWVPTVLNIL VQVTSCKCGF
LFFIFSETNG HGPNEFPEGS AGKGSYQVRG VCLIIKQFLA LLIKRWHHAT RSYKDFIAQI
VLPASFVFLA LMFTLIVPPF GEYPSVTLTP WMYGRQYTFF SNERPMDAQM RYFGEVLLDK
PGFGTRCMAD EPLEDFPCNN ITTEWEMPMV NPSLIEMLES PKWTPLRPSP ECQCSTSKKL
TMLPVCPEGA GGLPPPQRIQ STGDVLFDLT GRNISDYLVK TYPTLIRTSL KSKYWVNEQR
YMETENNVKV WYNNKGWHAM VSFMNVANNA ILRANLPKGA DLNEYGITVV NHPLNLTKEQ
LSEITVLTTS VDAVVAICVI FAMSFVPASF VLYLIQERVT QAKLLQFVSG VSPLVYWTAN
FLWDMVNYSI SAAMVVEIFL FFDKRCYTSP TNLQPLIALL MLYGWSVTPM MYPMSFVFSV
PSTAYVSLSC INLFIGINSS AITFILDLFE SSTGLYRFNQ MLKTVLLIFP HYCLGRGLID
MAMNQAVTDV YARFGEDYSP DPFNWDFIGK NLFCMAIEGF VYFILNILFQ YRFFLDHWIS
DSPKPHMLEE DKDVAEERER IHRSKNTFDI LRIKDLSKTY RGTMIPAVDR ICVGVSPGEC
FGLLGVNGAG KTTTFKMLTG DIDVTSGEAS VSGYSILTNI LDVHQNMGYC PQFGAIDELL
TGREHLHLYA RLRGVPESEI SRVAEWAIQK LGLSEYAGRS AGTYSGGNKR KLSTAIAMIG
CPTLVLLDEP TTGMDPLSRR FLWNSIMSVI QDRRAVVLTS HSMEECEALC TRLAIMVNGS
FKCLGTIQHL KYKFGDGYVV TMKIRAAKPG CLPDLNPAEA FMESTFPGSI QSEKHYNTLQ
YKISSPSLAR IFQMVLANKD KLNIEDYSVS QTTLDQVFVN FAKQQSREDD TIVLHPKAAG
AQRYIETTAI KSYRK
//
