ID M3ZNJ0_XIPMA Unreviewed; 675 AA.
AC M3ZNJ0;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=EPS8 like 2 {ECO:0000313|Ensembl:ENSXMAP00000003783.1};
GN Name=EPS8L2 {ECO:0000313|Ensembl:ENSXMAP00000003783.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000003783.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000003783.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000003783.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the EPS8 family.
CC {ECO:0000256|ARBA:ARBA00006197}.
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DR RefSeq; XP_014327231.1; XM_014471745.1.
DR AlphaFoldDB; M3ZNJ0; -.
DR STRING; 8083.ENSXMAP00000003783; -.
DR Ensembl; ENSXMAT00000003789.2; ENSXMAP00000003783.1; ENSXMAG00000003760.2.
DR GeneID; 102228056; -.
DR KEGG; xma:102228056; -.
DR CTD; 64787; -.
DR eggNOG; KOG3557; Eukaryota.
DR GeneTree; ENSGT00940000160990; -.
DR HOGENOM; CLU_014510_0_0_1; -.
DR InParanoid; M3ZNJ0; -.
DR OMA; RNTMALY; -.
DR OrthoDB; 2997036at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR CDD; cd01210; PTB_EPS8; 1.
DR CDD; cd09540; SAM_EPS8-like; 1.
DR CDD; cd11764; SH3_Eps8; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR039801; EPS8-like.
DR InterPro; IPR033928; EPS8_PTB.
DR InterPro; IPR035462; Eps8_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR013625; PTB.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR041418; SAM_3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12287:SF20; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 2; 1.
DR PANTHER; PTHR12287; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE EPS8-RELATED PROTEIN; 1.
DR Pfam; PF08416; PTB; 1.
DR Pfam; PF18016; SAM_3; 1.
DR Pfam; PF00018; SH3_1; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 456..515
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 188..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 520..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 649..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 530..544
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 656..675
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 675 AA; 76821 MW; D440E6CB7AE63AC9 CRC64;
MPEIMNAPGP LSRQANGVAR SDSKLSAKAL YEQRKKYSNS NFIMQETSQY HVEHLSTFVM
DKTESIVTVD DAIKKLILLD SRDKIWTQEM LLQVTDKAVR LLDCDTQEEL ENFPLTTVHL
CQTVLNQTRY PSVLLLVCQD RDQHKPDIHF FHCDQVEAEM VHADIDSALG DNKHGKKMRL
ETLKVNQEKM KRQRETILPP SSPRGPPPVA NRRAAAAANT HGPYDAESHE KLAQRIEKDV
QILNCALDDI EIFVARLQKA AEAFYQLNQR NKSKKNKKKG PAEGMLTLRA RPPSEAEFID
SLQKLKLALN LLAKLKKHLQ NPSAPELVHF LFGPLELVLQ TCGSPDLVRS VISPHLSMDA
VDFLRGHLTP KEMTMFELLG DGWTRPRAEW PKDQCAPPYY PKFRNGWEPP AEFFLTSPWE
TEGPPSPLAS PTSPDHRRHS PDDYYVNHSP PNGMHSNRKY AKICYNFVAR NPNELSVLQD
EILEVLEDNK QWWKLRNRSG QSGYVPYNIL DVVRLEEPEE PYPSDYRSSP TDPLHKRDSF
KGGIQKDKKM DEVNNELLMK ITANKNPPPR KIRIERPAAP QVPLTSESSP EQVTKWLNAK
AFSKQTVECL GILTGAQLFS LNKEELKAVC GEEGGRVFNQ VSLQKGQLEK TQGDSELQEI
MTRRKEKVDS TSSYD
//
