ID M4A0I4_XIPMA Unreviewed; 907 AA.
AC M4A0I4;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Unconventional myosin-Ih-like {ECO:0000313|Ensembl:ENSXMAP00000007978.2};
GN Name=MYO1H {ECO:0000313|Ensembl:ENSXMAP00000007978.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000007978.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000007978.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000007978.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR AlphaFoldDB; M4A0I4; -.
DR STRING; 8083.ENSXMAP00000007978; -.
DR Ensembl; ENSXMAT00000007986.2; ENSXMAP00000007978.2; ENSXMAG00000007888.2.
DR eggNOG; KOG0164; Eukaryota.
DR GeneTree; ENSGT00940000156430; -.
DR HOGENOM; CLU_000192_7_7_1; -.
DR InParanoid; M4A0I4; -.
DR OMA; DAYERCK; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01378; MYSc_Myo1; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF862; UNCONVENTIONAL MYOSIN-IH ISOFORM X1; 1.
DR Pfam; PF00063; Myosin_head; 2.
DR Pfam; PF06017; Myosin_TH1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 2.
DR PROSITE; PS51757; TH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 11..540
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 553..641
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 723..906
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT BINDING 104..111
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 907 AA; 104411 MW; 77914C511C9CDC03 CRC64;
MEGALTARDR VGIQDFVLLD ETTEVAVISN LKKRFSKDLI YTYIGTLIVS VNPYKDLDIY
NKKQMDVYMG VNFFELPPHI YALADNAYHT MLTEFNNHFI LISGESGAGK TEASKKILQY
YAVSCPSTTL MNTVRDKMLM SNPVLEAFGN AKTLKNDNSS RFGKYMDIQF DSQGDAVGGH
ILNYLLEKSR VVHQNHGERN FHVFYQLVEG GSDDLLTQLG LERDVQHYYY LTQGECAIVS
SINDKNDWKS VKNALQVIEF DETNTNHLFR VVASVLHLGN VHFDPDSKGH ALLKNNTELN
WVSDLLGVDA NNLKEGLTFR KIEAKTEQVL SPFTIDHAIY VRDALAKAIY GQTFTWLVNR
INESMENKDS SRKTVIGLLD IYGFEVFYVN SFEQFCINYC NEKLQQLFIQ LTLKAEQEEY
EAEGIEWEPV QFFNNKIICD LVEEKHRGII SILDEECLRP GDATDLTFLD RLEEKMGNHP
HFVTHRLADK MTRKTLERGD FRLLHYAGEV TYCVVGFLDK NNDLLYRNIK NVATQFKNSL
QKLTEIRLIQ STRHQVKYLG LMEHLRVRRA GFAYRRKYED FLKRYKPLCP ATWPHWRGMP
ADGVEVLAQH LGYLPDEYKM GRTKIFIRHP RTLYATEDAY EKCKHDLASK LQAKYKGYKV
KGEFKKQKEA ATKIETCWRG AQARKEKEKR AWAVKVIKKF IKAYINRGEA KSTDNSEYLA
FVRQSYLNRL KNNLPKTVLD KTTWLTPPAV LTEASEILRK LHYRLMVRKY VRGIPPQKKA
QLQMKVVTSA IFKGKKENYP PSIPQLFLDT RIRISVSSLS DGIIAIHITC EDPKQKGDLI
IQCEHLYEFL TKLSIIANKQ DAIKVVQGSI KIKIQSGKES SVDFTTGQEP MVYKAKNGHL
MVVSINK
//
