ID M4A0Y3_XIPMA Unreviewed; 2517 AA.
AC M4A0Y3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=LPS responsive beige-like anchor protein {ECO:0000313|Ensembl:ENSXMAP00000008127.2};
GN Name=LRBA {ECO:0000313|Ensembl:ENSXMAP00000008127.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000008127.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000008127.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000008127.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSXMAT00000008137.2; ENSXMAP00000008127.2; ENSXMAG00000014034.2.
DR eggNOG; KOG1787; Eukaryota.
DR GeneTree; ENSGT00940000154778; -.
DR HOGENOM; CLU_018661_0_0_1; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR CDD; cd06071; Beach; 1.
DR CDD; cd01201; PH_BEACH; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR010508; NBEA-like_DUF1088.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR046852; Neurobeachin_a-sol.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF64; LIPOPOLYSACCHARIDE-RESPONSIVE AND BEIGE-LIKE ANCHOR PROTEIN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF06469; DUF1088; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF20425; Neurobeachin; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 1994..2102
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2121..2410
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REGION 935..1232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1248..1285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1967..1998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..962
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..988
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1017
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1053..1078
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1086..1134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1156..1175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1183..1200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2517 AA; 279752 MW; 2F860B6DBFBE6C20 CRC64;
MASAEAAEPG DGKDGRAGAM QLNPTVPIRG IRMKFAVLAG LVEVGEVSNR DIVETVFNLL
VGGQFDLEMN FIIQEPESIV CMVELLDKCE PTCQAEIWSI FTAILKKSVR NLQVCTEVEL
IQQVLHRIST TDSMIADLLV DMLGVLASYS ITVKELKLFF SKLQGEQGQW PRHAVKLLSV
LKYMAHRNGP DSFFSFPGKN AAAIALPPIA RWPYQNGFTF HTWIRMDPLN NINVDKDKPY
LYCFRTNKGM GYSAHFVGGC LIVTSLKSKG KGFQHCVKYD FKPQKWYMVT LVHVYNRWKN
SEISCFVNGE LASYGDIAWF VNTSDTFDKC FLGSSETADV NRVFCGQMGA VYLFAEALSA
AQILAIYQLG PGYQGTFKHR AESDLLFEEH HKTLLYDGKL ASGIAFTYNP CATDAQLCLE
SSPKDNASIF VHSPHALMLQ DVKAVVTHSV QSGIHSIGGI QVLFPLFAQL DYWQPCSQEP
DTSVCCTLLS FMMELLKNSV SMQEQVLACK GFLVIGYTLE KSSKVHVTRP VLDIVLAFSR
YLSNLQNGIY LLKQLCDHIL FNPAIWIHAP AKVQLMLYTY LATEFISTVT IYNAVRRVGT
VLQVMHTLKY FYWVVNPHDR SGVIPKGVDG PRPNQKEMLS LRAFLLLFIK QLIMKDHGVK
EDELQSILNY LLTMHEDENL MDVLQLLVAL MSEHPGTMVQ AFDQRNGIRV IYKLLASKNE
GIRIQALKVM GYFLKSLSAK RKSEVMLTHG LFSLLTERLM LHSNPFTMTT YNSLFEILTE
QICTQVIHKQ HPDPDSSVKI VNPQMLKVIA ALLKNCPQSP ESMEVRRVFL SDMIKLFNNS
RENRRSLLQC SVWQEWMLSL CFVSPSNNEE QKITEMVYAV FRILLYHAIK YEWGGWRVWV
DTLSITHSKV RVLIMNQSSV TVSNILAGAE EEQKVEFSSG DQSNVDKETS TAVHKDEVTE
PASEKSSQNA ETSVNTQSEA SGPTTKEDSA APTKDDAQTE VAHLEQGDSS ELSTEEASVA
SEKGDESKQM SSEPPAPLEN SVLGGASVFN EDLVDVSSVS DQINPSDVDD SQEESSYASA
AAGEEGESVK KAEDEREGDG SKTKDLGEQE PKTEEGKQET ETVRREEQEK DSVENQVPCS
ESPAPETEVA DQSVKEPTKE NVSGPESSSK SEGAASDRQE AAAPEATPQS QPSESSMSAA
EETPPHAHDT STPGSSTSKT PDPARKTKET KIARLDVANV AVDTERLELK ETSITESSQG
QTTGAAGEAG SPPGRPEDSS TSAPRSTMFR IPEFRWSHMH QRLLTDLLFS IETDVQAWRS
HSTKTVLDFV NSSENTVFVH NSIHLVSQVV DNLIMACGGI LPLLSAATSA SHELENIEPS
QGLPVEASVT FLQRLINLAD VLIFASSLNF TEIEAEKNMS SGGILRQCLR LVCAIAVRNC
LECQQAQFKG AEGPTRSYTV MPSTASPVDA VTGGMSTVRD LDRLLQDMDI NRLRAVVFRD
IEDSKQAQFL ALAVVYFISV LMVSKYRDIL EPHNDRKPPL RSQSTRSTDF CGFTPCSKLL
YSSAEVENGV SLRRYDSGIG DDHTSAVASE ADLSSSGGPD AVSEALSTLS SEVRGSTSAD
SKSKNVKDIL RSLVSSPAED VMVDPSLLPL SFMGPVTHLD RRSSLQFRSF DRSVVVAPRQ
AGVLPSQVSP APAQTSAAAS VSAGTPVDGV AVVSSGDASQ VLSVDAADCN ISERLEHALE
KAAPLLREIF VDFAPFLSRT LLGSHGQELL IEGTSLVCMK SSSSVVELVM LLCSQEWQNS
IQKNAGLAFI ELVNEGRLLS HTMKDHLVRV ANEAEFILSR QRAEDIHKHA EFESNCAQYA
AEKRDEEKMC DHLIRAAKFR DHMTSTQLIQ KIVNILTDKH GAWGSSSVSR PREFWRLDYW
EDDLRRRRRF VRNPFGSSHS EAALKAAAEH ASEDDILKQS IRSQALANQN TESEASLDGD
DDTLSSLEDK DLENQTGPVN LSTSAQLVAP AAVVKGTLSV TASELFFEVE EDDPSYKAVD
PKILSYTEGL HGKWLFTEIR AVFSRRYLLQ NTALEVFMAN RTAVMFNFPD AATVKKVVHS
LPRVGLGTNF GLPQIRRISL ATPRQLFKTS NMTQRWQRRE ISNFEYLMFL NTIAGRTYND
LNQYPVFPWI ITNYESPELD LTLPSNYRDL SKPIGALNPK RAAFFSDRYE SWEDDQVPKF
HYGTHYSTSS FTLMWLLRIE PFTTFFLNFQ GGKFDHADRT FSSVFRAWRN CQRDTSDVKE
LIPEFFYLPE MFVNANNYNL GVMEDGTVVS DVDLPPWAKS SEEFVRINRQ ALESEFVSCQ
LHQWIDLIFG YKQQGPEAAR ALNVFYYLTY EGAVNLSSIN DPMLREAVES QIRSFGQTPS
QLLIEPHPPR SSAMQVTPLM FTEQMQQDVI MVLKFPSNSP VTHVAANTQP GLASPAIITV
TANRLFSVNK WHGLAGHQNA GEQQYQLPVE IDPLIGTLSF MTIKRNPRAP ECEPVYA
//
