ID M4A2W6_XIPMA Unreviewed; 592 AA.
AC M4A2W6;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Melanoma cell adhesion molecule {ECO:0000313|Ensembl:ENSXMAP00000008810.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000008810.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000008810.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000008810.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; M4A2W6; -.
DR Ensembl; ENSXMAT00000008824.2; ENSXMAP00000008810.2; ENSXMAG00000008782.2.
DR eggNOG; ENOG502QV1U; Eukaryota.
DR GeneTree; ENSGT00940000155838; -.
DR HOGENOM; CLU_028888_3_0_1; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR45889; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45889:SF8; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13895; Ig_2; 1.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..592
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017486196"
FT TRANSMEM 516..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 148..250
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 256..329
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 340..419
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 426..508
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 592 AA; 65504 MW; A066391FCAEDDCEA CRC64;
MAVRDAASPL LLGLLCLLHT WGARAAVEVN MEDKVEVLLG DPAQITCMFK SDDFGGSGGM
TIEWHYVKSS TDSQRIYSQD SLQSTVEKNT PYSDRITVNT TAREVVLTIR DVQLKDDEVA
FNCFVKIIGE GSGEGGTKLK VFKTPEDPTI QGVEQGISVS DEVTKVASCE VKNGHPKPKI
TWYRDKMPLH NIPDVVKLDH SVTTQSSGLY SVNSDLNMKV EKKDKDAVFY CEVTFLVPGA
EKMLETKRIN ITVFYPPTTV NLWVESPKGK IKEGDTVEFL CASDGNSESQ FFIIENNEGP
SLKMENVTRH NSGVFHCTVE DYENYVRLST NTTVLVNYLD EVVIKPTGSV SVDWKKEFSA
TCNALSSLST TTTWFKNGKE VEKGHHLNIK AVTYDTAGTY VCVVTVPEIQ AMQANASLQL
TVQGPPEIIE KQLNEKETNE RELELTCHVR SYPTPNIIWG TTNGKIISSS NHMTGVGAKS
VAKVQVNITS NTTVFCNASN EFGKDSVTYV IRFRSYGVVI AVIIICILLL AILGSVLYFL
YKKGKICNRS GKKDFTKEKS SKDKIVVEMK SDNTEEAILL GINGEKQLPN DQ
//
