ID M4A742_XIPMA Unreviewed; 1516 AA.
AC M4A742;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Nuclear receptor coactivator {ECO:0000256|PIRNR:PIRNR038181};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000010286.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000010286.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000010286.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR038181}.
CC -!- SIMILARITY: Belongs to the SRC/p160 nuclear receptor coactivator
CC family. {ECO:0000256|ARBA:ARBA00009933, ECO:0000256|PIRNR:PIRNR038181}.
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DR STRING; 8083.ENSXMAP00000010286; -.
DR Ensembl; ENSXMAT00000010300.2; ENSXMAP00000010286.2; ENSXMAG00000010250.2.
DR eggNOG; KOG3561; Eukaryota.
DR GeneTree; ENSGT00950000183021; -.
DR HOGENOM; CLU_001988_0_0_1; -.
DR InParanoid; M4A742; -.
DR OMA; PIMPNAQ; -.
DR OrthoDB; 4230728at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016922; F:nuclear receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd18950; bHLH-PAS_NCoA2_SRC2; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 6.10.140.20; Nuclear receptor coactivator, Ncoa-type, interlocking domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR010011; NCO_DUF1518.
DR InterPro; IPR032565; NCOA2/3_DUF4927.
DR InterPro; IPR028822; NCOA2_bHLH.
DR InterPro; IPR009110; Nuc_rcpt_coact.
DR InterPro; IPR014920; Nuc_rcpt_coact_Ncoa-typ.
DR InterPro; IPR037077; Nuc_rcpt_coact_Ncoa_int_sf.
DR InterPro; IPR017426; Nuclear_rcpt_coactivator.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR014935; SRC/p160_LXXLL.
DR PANTHER; PTHR10684; NUCLEAR RECEPTOR COACTIVATOR; 1.
DR PANTHER; PTHR10684:SF2; NUCLEAR RECEPTOR COACTIVATOR 2; 1.
DR Pfam; PF07469; DUF1518; 2.
DR Pfam; PF16279; DUF4927; 1.
DR Pfam; PF16665; NCOA_u2; 1.
DR Pfam; PF08815; Nuc_rec_co-act; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR Pfam; PF08832; SRC-1; 1.
DR PIRSF; PIRSF038181; Nuclear_receptor_coactivator; 1.
DR SMART; SM01151; DUF1518; 2.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF69125; Nuclear receptor coactivator interlocking domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159, ECO:0000256|PIRNR:PIRNR038181};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR038181};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|PIRNR:PIRNR038181};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|PIRNR:PIRNR038181}.
FT DOMAIN 28..85
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 121..185
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 946..987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1255..1374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1393..1516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 75..105
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 12..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..428
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 463..501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 593..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..651
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 951..968
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1258..1284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1299..1329
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1330..1347
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1350..1374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1516 AA; 163530 MW; 61C8B3F0FAF50FC1 CRC64;
MMSGVGENSS DPARAEARKR KECSAELIGP SPKRSNEKRN REHENKYIEE LAELIFANFN
DIDNFNVKPD KCAILKETVK QIRQIKEQEK AAAANEEEVQ KADVSSTGQS VIDKDALGPM
MLEALDGFFF VVNMEGNIVF VSENVTQYLR YNQEELMNTS VYSVLHVGDH AEFIKNLLPK
SLVNGVPWSS EGPRRNSHTF NCRMLVNPHS ENQDESHEPQ QQKYETMQCF AVSEPKSIKE
EGDDFQSCLI CVARRVPTKE RPMLPTHESF TTRQDLQGKI TSLDTSLLRA SMKPGWEDLV
RRCIQRFHLQ NDGEMSFAKR HQQEVLRHGQ AFSPIYRFSL SDGTIVSAHT KSKLVRSSAT
NEPQLYMSLH LLQREHPVCG MGQDIGGQET GMTPKPMNPS MTPPTPCSLP GLGLQGQDTT
ISSNSTPFSP PGPAGPREPA AMGGHMQGYR FGCPPPHPNY TGGMQPPQQG PNWRMNSPSR
ASPSPAGGPH PAQQNSMLSP RHRGSPGGAG SPRVAGGLQS PSPVGMCGSG PGSAGSTHSN
SYTSSSLSAL QALSECHGVG HGPSHAHTLG SPDRKIGSPA GVTPGSGVNP HMMSKFGGSS
SNAGGAGDFS SHSEVNQGHA EGNQTEPKEE REGSLDGHDS HDAHSRVHDN KGNTKLLQLL
TTKPEPLETP LSPGGGGEGK DQAGAGVRGG HAVGNTHATS LKEKHKILHQ LLQNSTSPVD
LAKLTAEATG KELGQDQSQG AGNQSSGAEI TPKQEPLSPK KKDNALLRYL LDKDDTVMKD
KVSKLEPGEV KVKEHPQVKV EKQDAGYDRA EQSSELDDIL NDLQSAQPQL FCEQRPVSLP
SPMDKQNIFN DILQMSENNA AMATQQQPRG LGMGQTNFGV VRPGQPGRAL PVRSVSLDMN
VPSQQPSLQY PIRANSPYPV MQQQQGMLGG HGMMPNQPGM GNAGLMTQGG PRPAMQQQQQ
QQSEGWTGPA SAPPIGASAP GQQGGMQGRM VPGTAPMRPN SQPGPRPMLQ SPLMANAQPD
MDINMVGHHF SQQQAPPNQT APWPDSMMPI DQTPFVNQNR PAQQDDLLCN PSLDQGSAVD
EGALMSQLYS ALKDFDGLEE IDRALGIPAL VEQSQSLEPD QFPQDSTIML DQKPPMYTQQ
FGPPPSHMVP RGFPGPPMQE PGFHLMAGQM GPRPTYPMMR MQPRPGLRPG GVAPNQPNAL
RLQLQHRLQS QQQKSQPMMT QMTGVSNVNL PLRASAPSQG NINAHMLAQR QREMLSNHLR
QRQQQQQQHV QQAQQVQQQR SIAMRAQGLG LPPNMAGGMS NPRNPQAAPQ QFPYPPSYGT
STGLASSPPP TSPFSSPLSP SLPSLPPNPQ LHLHGTSSSS TSSSSSQMMM GNTNMMGGQY
VGVLNPQMQH SAFQFPNSGM SQQADGSFAG GSTPQSPLLS PRMAHTQSPM MQQGQQNAAF
QGSPDMNGWP QGNMGGNSMF SQQQASPQFT QQNSGNMYNG NGMGLNNQLS SQMSVTSMAS
GSSPGLPSMG QEQKFC
//
