ID M4A7Y9_XIPMA Unreviewed; 429 AA.
AC M4A7Y9;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Dynein regulatory complex subunit 4 {ECO:0000256|ARBA:ARBA00021301};
DE AltName: Full=Growth arrest-specific protein 8 {ECO:0000256|ARBA:ARBA00031568};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000010583.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000010583.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000010583.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- SIMILARITY: Belongs to the DRC4 family.
CC {ECO:0000256|ARBA:ARBA00009859}.
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DR AlphaFoldDB; M4A7Y9; -.
DR STRING; 8083.ENSXMAP00000010583; -.
DR Ensembl; ENSXMAT00000010597.2; ENSXMAP00000010583.2; ENSXMAG00000010554.2.
DR eggNOG; ENOG502QQDA; Eukaryota.
DR GeneTree; ENSGT00390000009477; -.
DR HOGENOM; CLU_045343_0_0_1; -.
DR InParanoid; M4A7Y9; -.
DR OMA; MKHLQYE; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0048870; P:cell motility; IEA:InterPro.
DR InterPro; IPR039308; GAS8.
DR InterPro; IPR025593; GAS8_dom.
DR PANTHER; PTHR31543; DYNEIN REGULATORY COMPLEX SUBUNIT 4; 1.
DR PANTHER; PTHR31543:SF0; DYNEIN REGULATORY COMPLEX SUBUNIT 4; 1.
DR Pfam; PF13851; GAS; 1.
PE 3: Inferred from homology;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Flagellum {ECO:0000256|ARBA:ARBA00022846};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT DOMAIN 227..414
FT /note="Growth arrest-specific protein 8"
FT /evidence="ECO:0000259|Pfam:PF13851"
FT COILED 30..92
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 164..199
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 276..342
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 429 AA; 50476 MW; 1D1786706BAE93D0 CRC64;
MPPKKDEKKK KAEAKPPTLI NGLTKEEISR EQIEDHVVRL REVLDREREE RNYFQLERDK
IQSFREVTDR KHSEVKAELK NLEKAIEDDQ AHHLVGIKVF KQKMKHLLCE HHNTVTELEA
DIVTSTDVLE DEQSQLEADL YKEMMGILVE MQESSCEDVF KELLLKHEEE MTAAREKWER
LLRETAVRNK TEIQQLEKEH DNIMKSVTCE RELLWKSHFG NLNEDIERCI SDAKELISML
SRDTVKEITA LKECRDKKAL ELMLMKDEFF ALLKENKEFA KRVAKTENEY SRLERRSKSF
SQSEKQLINP QKKVLKDKKT EFEDLEEQFR TLQIEVEELQ SSVPKKIDIA QKQADLSLMP
LEDELTALND HVEQIHAQLH ALISAPNVDQ TAVTEITHKV EKELEIRNSA IKNLKHKRYL
ISTVSRIFT
//
