ID M4A852_XIPMA Unreviewed; 664 AA.
AC M4A852;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Discoidin, CUB and LCCL domain-containing protein 1-like {ECO:0000313|Ensembl:ENSXMAP00000010646.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000010646.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000010646.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000010646.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR AlphaFoldDB; M4A852; -.
DR STRING; 8083.ENSXMAP00000010646; -.
DR Ensembl; ENSXMAT00000010660.2; ENSXMAP00000010646.2; ENSXMAG00000010623.2.
DR eggNOG; ENOG502QQ36; Eukaryota.
DR GeneTree; ENSGT00940000164800; -.
DR HOGENOM; CLU_016654_1_0_1; -.
DR InParanoid; M4A852; -.
DR OMA; DCPSHRM; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032101; P:regulation of response to external stimulus; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00057; FA58C; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.170.130.20; LCCL-like domain; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR004043; LCCL.
DR InterPro; IPR036609; LCCL_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR46806; F5/8 TYPE C DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46806:SF6; SI:DKEY-34D22.1; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF03815; LCCL; 1.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00231; FA58C; 1.
DR SMART; SM00603; LCCL; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF69848; LCCL domain; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS50820; LCCL; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00059};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..664
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017189326"
FT TRANSMEM 450..473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..151
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 153..249
FT /note="LCCL"
FT /evidence="ECO:0000259|PROSITE:PS50820"
FT DOMAIN 246..400
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT REGION 406..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..435
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 38..65
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 664 AA; 72493 MW; 72716ACB758BC4AF CRC64;
MLGKSKSIED GMKFVFASFW ITFCACVGDV RCQEGNGCGH ALLGTESGTI ASPNYPGTYP
SNAWCKWRLR VQEGRTLRLL FGDFDIESSP GCRNGSIVIT GKSGERRLGP VCGKLNATMN
NVTLETNEVT VTFMSGPHRS GRGFLLSYAT DQHPDLISCL QRGSHFSFQH LRVYCPAGCK
NVPGEIWGNS EQGYRDTSVL CKSAVHSGAT SDALGGRITV NQGRSLTLYE STFANGVLSK
TGSLSDKKLL FSKECSNILA VSALNASSFW DKNSQEHTVF SASRNTESSH DFLLWTADHG
DPNPWVEIEL SERSTVTGLV TTGSSVSYME SYSLQFSKDR KSWKTYKDAM SKEKKVFQAY
TDGHLRVLNS LFPAVVARFV RLQPLSWHTR ASARVQLLGC PAVKVTPRSR PPGESPSIKF
NMDTLNPSPS PTPTEKALSV ETTLTHSQPV IIAVGVVLGL VMCGSCLLAR IWWKRRKKDS
VMKNSLPTVG CQAFKAKSLP CPQSELISYP LVRSVHDALP SPPLNDYAAP AIPSVGQKVG
STFRPSSDEG YTTPFTCAHY DTPGNLPEYA EPLPPEPEYA TPFSELPPEH KPPSLSGLLH
GIMHRPAHAP SGHSQYDCPS HRVLFNGYCT PALHASGPRP ASEVYAEPKP SDSLVQKHTY
EEPL
//
