ID M4A901_XIPMA Unreviewed; 1483 AA.
AC M4A901;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Neurexin 1 {ECO:0000313|Ensembl:ENSXMAP00000010945.2};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000010945.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000010945.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000010945.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the neurexin family.
CC {ECO:0000256|ARBA:ARBA00010241}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_005806867.1; XM_005806810.2.
DR Ensembl; ENSXMAT00000010959.2; ENSXMAP00000010945.2; ENSXMAG00000010885.2.
DR eggNOG; KOG3514; Eukaryota.
DR GeneTree; ENSGT00940000154292; -.
DR HOGENOM; CLU_001710_0_1_1; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00110; LamG; 6.
DR Gene3D; 2.60.120.200; -; 6.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR003585; Neurexin-like.
DR InterPro; IPR027789; Syndecan/Neurexin_dom.
DR PANTHER; PTHR15036:SF49; AXOTACTIN; 1.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR Pfam; PF00008; EGF; 1.
DR Pfam; PF02210; Laminin_G_2; 6.
DR Pfam; PF01034; Syndecan; 1.
DR SMART; SM00294; 4.1m; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00282; LamG; 6.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 6.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 6.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1409..1429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..208
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 198..236
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 259..449
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 456..649
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 653..690
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 695..868
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 882..1057
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1060..1097
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1101..1303
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1307..1329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1338..1357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1363..1400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1450..1483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1450..1466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1467..1483
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1483 AA; 163711 MW; 99D384782069AB49 CRC64;
MVVQKLHSAH FIWVGILICC FIEIGTCLEF TGTEGQWARF PVWNACCESE MSFNMKTKSS
HGVLVYFDDE GFCDFLELLL INGKLSLRYS IFCAEPATVV SDTAVNDSQW HNVTIRRSFK
NTTLSVDGEI KWVEAKSKRR DMTVFSHLFI GGIPPELRSV VLHLTSAAVK DQPPFAGWIT
DIKVNNTESE MINSEGVLLD VCGTANMCLN GGVCSLINSE PTCDCSHTGF QGKDCSEEDN
NTKGLAHLMM GDQGKEEYVA TFKGSEFFCY DLSLNPIQSS SDEITLSFKT LQRNGLMLHT
GKSADYVNLA LKNGAVSLVI NLGSGAFEAL VEPVNGKFND NEWHDVKVTR NLRQHSGIGH
AMVTISVDGI LTTTGYTQED YTMLGSDDFF YVGGSPSTAD LPGSPVSNNF MGCLKEVVYK
NNDVRLELSR LAKQDDPKMK IHGTVAFKCE NVATLDPITF ETPESYIILN KWNAKKTGSI
SFDFRTTEPN GLLLFSHGKS KQQPKDSKTP QTLKVDFFAI EMLDGHLYLL LDMGSGTTKT
KAVNKKVNDG EWYHVDFQRD GRSGTISINT LRTAYTAPGE SEILDLDDNL YLGGLPENKM
GLVFPTEVWT ALLNYGYVGC IRDLFIDGQS KDVRRLAEIQ KAAGVKPSCS KEPPKQCLSN
PCQNNGVCRE GWNRYVCDCS GTGYLGRSCE REATILSYDG SKFMKVQLPV VMRTEAEDVS
LRFRSQRAYG LLIATTSRES ADALRLELES GRVRLTVNLD CIRINCTSSK GPETIFAGQN
LNDNEWHTVR VFRRGKSLKL TVDELPPVEG QMAGDHTQLE FHNIETGIVT EKRFMSMVPS
NFIGHLQSLS FNGMAYIDLC KNGDIDYCEL NAMIGFKNII ADPVTFKSRS SYVTLTTLQA
YYSMHLFFQF KTTSPDGLIL YNSGDGNDFI VVELVKGYLH YVSDLGNGAH LIKGNSNKPL
SDNQWHNVII SRDTNNLHTV KIDTKVTTQT TSGAKNLDLK GNLYIGGVAK EMYKDLPKLV
HAKEGFQGCL ASVDLNGRLP DLMSDALDCV GQIERGCEGP STTCQEDSCA NQGVCLQQWE
GFSCDCSMTT FGGPLCNDAG TTYIFGRDGG LITYTWPPND RPSTRADRLA IGFSTHLKDA
VLVRVDSSSG LGDFLKLHIE KGNIAVVFNV GTDDINIEET SKFVNDGKYH IVKFTRSGGN
ATLQVDDLPV IERYPTGNID NERLALARQR IPYRLGRVVD EWLLDKGRQL TIFNSQTTIQ
IGGWERDRSR SFQGQLSGLY YNGLKVFNMA AEGDPNIKIQ GSVRLVGESP SSITPQSSTT
ANRSETSTSI MEITTTTAST RRIKQTTPRE PQQTTDDLMV ASAECPSDDE DIDPCEPSSG
GLASPTGSGP KGYPGTSEVF RESSSTTGMV VGIVAAAALC ILILLYAMYK YRNRDEGSYH
VDESRNYISN SAQSNGTVVK EKPINNPKTS SKNKKNKDKE YYV
//
