ID M4ATL3_XIPMA Unreviewed; 452 AA.
AC M4ATL3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Integrin-linked protein kinase {ECO:0000256|ARBA:ARBA00015063};
DE AltName: Full=59 kDa serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00032103};
DE AltName: Full=Beta-integrin-linked kinase {ECO:0000256|ARBA:ARBA00031016};
DE AltName: Full=ILK-1 {ECO:0000256|ARBA:ARBA00030970};
DE AltName: Full=ILK-2 {ECO:0000256|ARBA:ARBA00030969};
DE AltName: Full=p59ILK {ECO:0000256|ARBA:ARBA00029809};
GN Name=ILK {ECO:0000313|Ensembl:ENSXMAP00000017808.1};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000017808.1, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000017808.1}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000017808.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}. Cytoplasm, myofibril, sarcomere
CC {ECO:0000256|ARBA:ARBA00004204}.
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DR RefSeq; XP_005807118.1; XM_005807061.2.
DR AlphaFoldDB; M4ATL3; -.
DR STRING; 8083.ENSXMAP00000017808; -.
DR Ensembl; ENSXMAT00000017833.2; ENSXMAP00000017808.1; ENSXMAG00000017763.2.
DR GeneID; 102231522; -.
DR KEGG; xma:102231522; -.
DR CTD; 3611; -.
DR eggNOG; KOG0195; Eukaryota.
DR GeneTree; ENSGT00940000155956; -.
DR HOGENOM; CLU_000288_7_5_1; -.
DR InParanoid; M4ATL3; -.
DR OMA; VIITHYM; -.
DR OrthoDB; 2127408at2759; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd14057; PK_ILK; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR035692; PK_ILK.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR23257:SF967; INTEGRIN-LINKED PROTEIN KINASE; 1.
DR PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PIRSF; PIRSF000654; Integrin-linked_kinase; 1.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT REPEAT 33..65
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 66..98
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 99..131
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 193..446
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
SQ SEQUENCE 452 AA; 51354 MW; 9546395FFBD3D3B1 CRC64;
MDDIFTQCRE GNSVAVRLWL DNTENDLNLG DDHGFSPLHW ACREGRSGVV DMLIMRGARI
NVMNRGDDTP LHLAASHGHR DIVAKLIQCK ADPNTVNEHG NTPLHYACFW GHDEVAEDLV
THGAQVCICN RYGQTPLDKA KPHLKQLLQE KAEKMGQNMA KIPYKETFWK GTMRTRPRNG
TLNKQAGIDF KQLSLLAKIN ENQSGELWQG RWQGDEIVVK VLHVRDWTTR KSRDFNEEHP
KLRIFSHPNI LPVLGACQSP PSPHPIIIAH YMPYGSLYTI LHQGTTLVVD QSQAVKFALD
IASGMAFLHT LEPMVSRLYL NSKYIMIDED MTARISMADA KFSFQCPGRM YSPAWMAPEA
LQKKPEDINR RSADMWSFAV LLWELVTREV PFADLSNMEI GMKIALEGLR PTIPPGISPH
ICKLMRLCMN EDPAKRPKFD MIVPILEKMQ DK
//
