ID M4AVM3_XIPMA Unreviewed; 1150 AA.
AC M4AVM3;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 05-DEC-2018, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=WD repeat-containing protein 35 {ECO:0000256|PIRNR:PIRNR037536};
OS Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC Xiphophorus.
OX NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000018518.2, ECO:0000313|Proteomes:UP000002852};
RN [1] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA Walter R., Schartl M., Warren W.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000002852}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX PubMed=23542700; DOI=10.1038/ng.2604;
RA Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA Postlethwait J.H., Warren W.C.;
RT "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT evolutionary adaptation and several complex traits.";
RL Nat. Genet. 45:567-572(2013).
RN [3] {ECO:0000313|Ensembl:ENSXMAP00000018518.2}
RP IDENTIFICATION.
RC STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000018518.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|PIRNR:PIRNR037536}. Cytoplasm,
CC cytoskeleton, cilium basal body {ECO:0000256|PIRNR:PIRNR037536}.
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DR AlphaFoldDB; M4AVM3; -.
DR Ensembl; ENSXMAT00000018546.2; ENSXMAP00000018518.2; ENSXMAG00000018465.2.
DR eggNOG; KOG2041; Eukaryota.
DR GeneTree; ENSGT00940000155745; -.
DR HOGENOM; CLU_004048_1_0_1; -.
DR Proteomes; UP000002852; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0036064; C:ciliary basal body; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030991; C:intraciliary transport particle A; IEA:UniProtKB-UniRule.
DR GO; GO:0060271; P:cilium assembly; IEA:InterPro.
DR GO; GO:0035721; P:intraciliary retrograde transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.470; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039857; Ift122/121.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR017233; WDR35.
DR PANTHER; PTHR12764:SF5; LD29485P; 1.
DR PANTHER; PTHR12764; WD REPEAT DOMAIN-RELATED; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 1.
DR PIRSF; PIRSF037536; WD_repeat_p35; 2.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|PIRNR:PIRNR037536};
KW Cilium {ECO:0000256|PIRNR:PIRNR037536};
KW Cilium biogenesis/degradation {ECO:0000256|PIRNR:PIRNR037536};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037536};
KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR037536};
KW Reference proteome {ECO:0000313|Proteomes:UP000002852};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 67..98
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 144..193
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
SQ SEQUENCE 1150 AA; 129851 MW; 0A01E396C33C0ACD CRC64;
MFIYLSKKIA IPNNVHLKCL SWNKHQGFIA CGGEDGLLRV LKLETQTDDS RLKGLAAPSN
LSMNQTLEGH SGAVQVVTWN ERNEKLTTSD QNGLIIVWML YKSAWYEEMI NNRNKSVVRS
MSWNADGQKI CIVYEDGAVI VGSVDGNRIW GKELKGSQLA HVAWSPDSKI LLFGMANGEV
HIYDNQGNFI MKMNINCLAG ATGAVSLAGI HWYAGAGGYS EPDCPCLAIC FDNGRCQIMR
YENDENPVYI DTLMNVISIQ WNHCGSVLAV AGSLRATNMD KEYNVVQFYT PFGEHLRTLK
VSGKHLSGIS WEGGGLRIAL AVDSYIYFAN IRPDYKWGYC CSTVVYAYTK PERQEYCVVY
WDTKNNEKFV KYVKNLTSIT TSGDFCILAS KADEKQPQVI KEQDFYVLIL CNSIGTPLDS
KYIDIDPLFV TMTRTHVITA SKEAFYLWQY RVAKKLTALE INQVTRTKKG DPICCITATD
KTLIVGRESG IIQRYTLPNV ALVQKYSSNS RAHYLSLNCN SSRLAIIDIS GLLTLLDLEV
RPAGSEGTGD QAAAGDPSKF ERKDVWDLKW ANDNPDLFAV MEKTRMYVFR NLDPEEPIQT
SGYICNFEDL EIKSVLLDEI MKNPERPNKD NLFNFEIRSL RDSRALIEKV GIEDASQFIE
DNPHPRLWHL LAEAALQKLD LKTAEEAFVR CKDYPGIQFV KRLGNLQSEP MKQAEVAAYF
GRFEEAESMY LNMDRRDLAI NLRIKLGDWF KVLQLLDTGS GYSDDALLAQ ANNGIGDYFA
DRQKWVKAVP YYLKGRNQER LADCYYKLED YNGLELLAAD LPENHKLLPE IGEMFATVGM
CEQAVKAYLK SNQPKAAVDT CVHLNQWNKA VELARTHNMK EIKSLLSKYA SHLLEENKTL
EAVELYRKAH HFLDAAKLMF KIADKEAKKM SRPLRVKKLY VLAAQLVEDY HEQMKASQQI
KAKGKKSEAT FALAGLLEED ATSSDNRIID SAWRGAEAYH FFLLAQRQLH AGYPENATRT
ALHLREYEDI IPAVEIYSLL ALCSAANRSF GTCSKAFIKL ESLESLSSEQ QQLYEDLALQ
IFTKYPPKDS RVVEAQGSSE GAEGKLPTCI VTGRPIQEYQ FWMCSVCKHC AVEQEISKYN
CCPLCHSAVV
//
