ID   M4AW38_XIPMA            Unreviewed;      1028 AA.
AC   M4AW38;
DT   01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 2.
DT   27-MAR-2024, entry version 59.
DE   SubName: Full=Rho/Rac guanine nucleotide exchange factor 18 {ECO:0000313|Ensembl:ENSXMAP00000018683.2};
GN   Name=ARHGEF18 {ECO:0000313|Ensembl:ENSXMAP00000018683.2};
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Xiphophorus.
OX   NCBI_TaxID=8083 {ECO:0000313|Ensembl:ENSXMAP00000018683.2, ECO:0000313|Proteomes:UP000002852};
RN   [1] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RA   Walter R., Schartl M., Warren W.;
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000002852}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP 163 A {ECO:0000313|Proteomes:UP000002852};
RX   PubMed=23542700; DOI=10.1038/ng.2604;
RA   Schartl M., Walter R.B., Shen Y., Garcia T., Catchen J., Amores A.,
RA   Braasch I., Chalopin D., Volff J.N., Lesch K.P., Bisazza A., Minx P.,
RA   Hillier L., Wilson R.K., Fuerstenberg S., Boore J., Searle S.,
RA   Postlethwait J.H., Warren W.C.;
RT   "The genome of the platyfish, Xiphophorus maculatus, provides insights into
RT   evolutionary adaptation and several complex traits.";
RL   Nat. Genet. 45:567-572(2013).
RN   [3] {ECO:0000313|Ensembl:ENSXMAP00000018683.2}
RP   IDENTIFICATION.
RC   STRAIN=JP 163 A {ECO:0000313|Ensembl:ENSXMAP00000018683.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   AlphaFoldDB; M4AW38; -.
DR   Ensembl; ENSXMAT00000018711.2; ENSXMAP00000018683.2; ENSXMAG00000018641.2.
DR   eggNOG; KOG3520; Eukaryota.
DR   GeneTree; ENSGT00940000157375; -.
DR   HOGENOM; CLU_002466_0_1_1; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041020; PH_16.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR13944; AGAP007712-PA; 1.
DR   PANTHER; PTHR13944:SF23; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 18; 1.
DR   Pfam; PF17838; PH_16; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002852}.
FT   DOMAIN          115..312
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          354..456
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          584..625
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          726..746
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          917..944
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        586..600
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1028 AA;  116526 MW;  B22C1F07869E4432 CRC64;
     MTVSSFGAST QPSASLSSSF AAAPACSVGP SLRHHSSSGS LPGDMDEIDS LRSKRCNDDA
     VSLAPSIAES IIVEDAHYAA VRADLESDAQ DLEADSWSLA VDQYYLKKHS KDVVKRQDVI
     YELMQTEMHH VRTLKIMLRV YVREMKENLQ MDSGRLDCLF PRLENLLDLH THFLSCLRER
     RRENLVSPSD RNYTINRVAD ILIAQFSGEI GERMKNCYGD FCSHHTEAVS LYKEMLQNNR
     RFQNLIRKIS NLSIVRRLGV TECILLVTQR ITKYPVLVER ILHNTEANTE EHQDLTRALS
     LIKDTIKEVD TLVNLHEKES RLRDIHSKME PKTQGKIKDD RVFRREDLAQ GRRWLLHEGT
     VSWKAASGRL KDILAVLLSD VLLLLQEKDQ RYVFATVDNK PSVISLQKLI VREVAHEEKA
     MFLICASSNE PEMYEIHTAS KEERNSWMTY IRQAVESCPH SEERLFSEEE EARAARLREF
     QERLSQRDAV IAQALTEKLQ LFAEMAGSVA GLEDTASRSK LLLRSDASDL QQGEVLLKGA
     ITDVENLQNL LQAGVKEEAQ ATQTEDGSVS GVLPRRAGTF GGYDSSPVIL SKNGSAKKSF
     SGESRNRDRS QRASSDPQLK GLRGSHTLEQ TVGAKQVHTQ GVLKCISLFF DKVLMLSQRL
     YSLQAIVSQQ DSQIELQKAS LTERVSLPGR NKGNGLLEQE KQRTLALQRE ELAYLNKLQS
     QHRQEQQRWE KERERHRQQV EATEARLQQR EEECRKLEEQ LAKEKEELDR QRETYQKDLE
     RLRESTRAVE KEKERLESQR KMKRKTIEVS SLNNIDANLL KEETRLITSS PNNLKYITST
     CVAELPHSQK PLVRGSLSVA QADYPERPEI MLRRDTSSST LPLPQKTEVP LHLFSTTNQQ
     HKPVGVQQQI PTKLAAINSG KGKGSKSGKA SHRTDSSASV DMKQMLPLKL SARDDNVLKE
     KRSFSPHQQP LQSHSLSADS LPFQPHLQPH CLSQIAQANA SLNVHGLSVT PPYSLPAEDL
     NKEDVIFF
//