ID M4C0H5_HYAAE Unreviewed; 660 AA.
AC M4C0H5;
DT 01-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 01-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
OS Hyaloperonospora arabidopsidis (strain Emoy2) (Downy mildew agent)
OS (Peronospora arabidopsidis).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Hyaloperonospora.
OX NCBI_TaxID=559515 {ECO:0000313|EnsemblProtists:HpaP812425, ECO:0000313|Proteomes:UP000011713};
RN [1] {ECO:0000313|Proteomes:UP000011713}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Emoy2 {ECO:0000313|Proteomes:UP000011713};
RX PubMed=21148394; DOI=10.1126/science.1195203;
RA Baxter L., Tripathy S., Ishaque N., Boot N., Cabral A., Kemen E.,
RA Thines M., Ah-Fong A., Anderson R., Badejoko W., Bittner-Eddy P.,
RA Boore J.L., Chibucos M.C., Coates M., Dehal P., Delehaunty K., Dong S.,
RA Downton P., Dumas B., Fabro G., Fronick C., Fuerstenberg S.I., Fulton L.,
RA Gaulin E., Govers F., Hughes L., Humphray S., Jiang R.H., Judelson H.,
RA Kamoun S., Kyung K., Meijer H., Minx P., Morris P., Nelson J.,
RA Phuntumart V., Qutob D., Rehmany A., Rougon-Cardoso A., Ryden P.,
RA Torto-Alalibo T., Studholme D., Wang Y., Win J., Wood J., Clifton S.W.,
RA Rogers J., Van den Ackerveken G., Jones J.D., McDowell J.M., Beynon J.,
RA Tyler B.M.;
RT "Signatures of adaptation to obligate biotrophy in the Hyaloperonospora
RT arabidopsidis genome.";
RL Science 330:1549-1551(2010).
RN [2] {ECO:0000313|EnsemblProtists:HpaP812425}
RP IDENTIFICATION.
RC STRAIN=Emoy2 {ECO:0000313|EnsemblProtists:HpaP812425};
RG EnsemblProtists;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; JH598076; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; M4C0H5; -.
DR STRING; 559515.M4C0H5; -.
DR EnsemblProtists; HpaT812425; HpaP812425; HpaG812425.
DR VEuPathDB; FungiDB:HpaG812425; -.
DR eggNOG; KOG4177; Eukaryota.
DR HOGENOM; CLU_003933_2_0_1; -.
DR InParanoid; M4C0H5; -.
DR OMA; GIVCYSD; -.
DR Proteomes; UP000011713; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24178; MOLTING PROTEIN MLT-4; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13676; TIR_2; 2.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 2.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000011713}.
FT REPEAT 128..160
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 161..193
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 285..424
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 660 AA; 72768 MW; B386D0719AC0F41B CRC64;
MGQLATVRWL LERGVPPGTL AKASYRSNRI PPLFLAEHAE IARELLLHGA DPLVIPDPGY
MNTITPVQLA YIRGNFAVAR ELEEWGSDVA LTPFHLAAAR NDVAAVRRFV AWKTDVNCLG
EMGYVGLNRR TPLHWAAISG STGAVDALLE GQADPNFQDV RGRSPLHWAT QLNKLDVVRS
LLRANADPNL LDRDFKTPLM CAASARNVSR ELFSELTAAG GNISYQLPTT GDTVLHVAVR
EENEASALAA LACGGDLMRM NNEGLRPLDC TLSTRLLFGL KRAAGQRDVM ISYTHSHQEF
ALKLRQSLEE ANVTTWLDLM DPSGIGGGAV WREEIARGIT NASVVLCILT EDYAASEWCL
KELALAKQVG TPILAVSTEG ASIDDDLQVY VYTRQIVPFE PAITGVRCDE GRVEYDYEES
RYRFQFHLLL DGVRDEIEKN RHVTRRNNVA SSRRTDLGME LESGSNRGTM LQTFSATPLS
QGTDSCSLTT LSVSHGRRFV FLSHGDKHAA FVRQLASQLT DGGIVCYSDQ NRSGQDFNTR
IQVAQEAIMR CSCFVVLVSR QTIGNELVRD QLAFAEDKAR PIFPVVLNDL EPGLDKLYTL
VRSDLFHFMA NGAGFNASCS KLMSDLRHYC NIVEAVGSTG GSDSENIRNL WTTLKSSRKT
//
