ID M4M593_9HIV1 Unreviewed; 739 AA.
AC M4M593;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|RuleBase:RU363095};
DE Contains:
DE RecName: Full=Surface protein gp120 {ECO:0000256|RuleBase:RU363095};
DE Short=SU {ECO:0000256|RuleBase:RU363095};
DE AltName: Full=Glycoprotein 120 {ECO:0000256|RuleBase:RU363095};
DE Short=gp120 {ECO:0000256|RuleBase:RU363095};
DE Contains:
DE RecName: Full=Transmembrane protein gp41 {ECO:0000256|RuleBase:RU363095};
DE Short=TM {ECO:0000256|RuleBase:RU363095};
GN Name=env {ECO:0000313|EMBL:AGG24617.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AGG24617.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AGG24617.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=703010505_w20_10 {ECO:0000313|EMBL:AGG24617.1};
RA Liao H.-X., Lynch R., Zhou T., Gao F., Munir Alam S., Boyd S.D., Fire A.Z.,
RA Roskin K.M., Schramm C.A., Zhang Z., Zhu J., Shapiro L., Mullikin J.C.,
RA Gnanakaran S., Hraber P., Weihe K., Kelsoe G., Yang G., Xia S.-M.,
RA Montefiori D.C., Parks R., Lloyd K.E., Scearce R.M., Soderberg K.D.,
RA Cohen M., Kaminga G., Louder M.K., Tran L.M., Chen Y., Cai F., Chen S.,
RA Moquin S., Du X., Joyce G.M., Srivatsan S., Zhang B., Zheng A., Shaw G.M.,
RA Hahn B.H., Kepler T.B., Korber B.T., Kwong P.D., Mascola J.R., Haynes B.F.;
RL Submitted (NOV-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AGG24617.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=703010505_w20_10 {ECO:0000313|EMBL:AGG24617.1};
RX PubMed=23552890; DOI=10.1038/nature12053;
RG NISC Comparative Sequencing Program;
RA Liao H.X., Lynch R., Zhou T., Gao F., Alam S.M., Boyd S.D., Fire A.Z.,
RA Roskin K.M., Schramm C.A., Zhang Z., Zhu J., Shapiro L., Mullikin J.C.,
RA Gnanakaran S., Hraber P., Wiehe K., Kelsoe G., Yang G., Xia S.M.,
RA Montefiori D.C., Parks R., Lloyd K.E., Scearce R.M., Soderberg K.A.,
RA Cohen M., Kamanga G., Louder M.K., Tran L.M., Chen Y., Cai F., Chen S.,
RA Moquin S., Du X., Joyce M.G., Srivatsan S., Zhang B., Zheng A., Shaw G.M.,
RA Hahn B.H., Kepler T.B., Korber B.T., Kwong P.D., Mascola J.R., Haynes B.F.,
RA Becker J., Benjamin B., Blakesley R., Bouffard G., Brooks S., Coleman H.,
RA Dekhtyar M., Gregory M., Guan X., Gupta J., Han J., Hargrove A., Ho S.L.,
RA Johnson T., Legaspi R., Lovett S., Maduro Q., Masiello C., Maskeri B.,
RA McDowell J., Montemayor C., Mullikin J., Park M., Riebow N., Schandler K.,
RA Schmidt B., Sison C., Stantripop M., Thomas J., Thomas P., Vemulapalli M.,
RA Young A.;
RT "Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus.";
RL Nature 496:469-476(2013).
CC -!- SUBUNIT: The mature envelope protein (Env) consists of a homotrimer of
CC non-covalently associated gp120-gp41 heterodimers. The resulting
CC complex protrudes from the virus surface as a spike.
CC {ECO:0000256|RuleBase:RU363095}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
CC -!- DOMAIN: The 17 amino acids long immunosuppressive region is present in
CC many retroviral envelope proteins. Synthetic peptides derived from this
CC relatively conserved sequence inhibit immune function in vitro and in
CC vivo. {ECO:0000256|RuleBase:RU363095}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU363095}.
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DR EMBL; KC247484; AGG24617.1; -; Genomic_RNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 2.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 2.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703, ECO:0000256|RuleBase:RU363095};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685,
KW ECO:0000256|RuleBase:RU363095};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Fusion of virus membrane with host membrane
KW {ECO:0000256|RuleBase:RU363095};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511,
KW ECO:0000256|RuleBase:RU363095};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046,
KW ECO:0000256|RuleBase:RU363095};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870,
KW ECO:0000256|RuleBase:RU363095};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581,
KW ECO:0000256|RuleBase:RU363095};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363095};
KW Transmembrane {ECO:0000256|RuleBase:RU363095};
KW Transmembrane helix {ECO:0000256|RuleBase:RU363095};
KW Viral attachment to host cell {ECO:0000256|RuleBase:RU363095};
KW Viral envelope protein {ECO:0000256|RuleBase:RU363095,
KW ECO:0000313|EMBL:AGG24617.1};
KW Viral penetration into host cytoplasm {ECO:0000256|RuleBase:RU363095};
KW Virion {ECO:0000256|RuleBase:RU363095};
KW Virus entry into host cell {ECO:0000256|RuleBase:RU363095}.
FT TRANSMEM 12..38
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363095"
FT TRANSMEM 554..581
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363095"
FT DOMAIN 30..133
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 138..485
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 481..596
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 595..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 739 AA; 84204 MW; 7C0846D42E2AC575 CRC64;
MRVMGIQRNY PQWWIWNMLG FWMLMICNGM WVTVYYGVPV WKEAKTTLFC ASDAKAYEKE
VHNVWATHAC VPTDPNPQEM VLKNVTENFN MWKNDMVDQM HEDVISLWDQ SLKPCVKLTP
LCVTLNCTNA TTNNSSIIEG MKNCSFNITT ELRDKREKKN ALFYKLDIVQ LDGNSSQYRL
INCNTSVITQ ACPKVSFDPI PIHYCAPAGY AILKCNNKTF TGTGPCNNVS TVQCTHGIKP
VVSTQLLLNG SLAEGEIIIR SENITNNGKT IIVHLNESVK IECTRPNNKT RTSIRIGPGQ
AFYATGQVIG DIREAYCNIS ESKWNETLQR VSKKLKEYFP HKNITFQPSS GGDLEITTHS
FNCGGEFFYC NTSSLFNRTY MANSTDMANS TETNSTRTIT IRCRIKQIIN MWQEVGRAMY
APPIAGNITC ISNITGLLLT RDGGKNNTET FRPGGGNMKD NWRSELYKYK VVEVKPLGVA
PTNVYWNSSW SNKTYGDIWD NMTWMQWERE ISNYTEIIYE LLEESQNQQE KNEQDLLALD
RWNSLWNWFN ITNWLWYIKI FIMIVGGLIG LRIIFAVLSL VNRVRQGYSP LSLQTLIPSP
RGPDRPGGIE EEGGEQDRNR STRLVSGFLA LVWDDLRSLC LFIYHRLRDF ILIAARAGEL
LGRSSLKGLR RGWEALKYLG SLVQYWGLEL KRSAISLLDT LAIAVGEGTD RILEFVLGIC
RAIRNIPTRI RQGFETALL
//
