ID   M4Q3C2_9HEPA            Unreviewed;       853 AA.
AC   M4Q3C2;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 51.
DE   RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE            EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
OS   Bat hepatitis virus.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae.
OX   NCBI_TaxID=1303386 {ECO:0000313|EMBL:AGH10174.1, ECO:0000313|Proteomes:UP000171699};
RN   [1] {ECO:0000313|EMBL:AGH10174.1, ECO:0000313|Proteomes:UP000171699}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M086 {ECO:0000313|EMBL:AGH10174.1};
RX   PubMed=23631923; DOI=10.3201/eid1904.121655;
RA   He B., Fan Q., Yang F., Hu T., Qiu W., Feng Y., Li Z., Li Y., Zhang F.,
RA   Guo H., Zou X., Tu C.;
RT   "Hepatitis virus in long-fingered bats, myanmar.";
RL   Emerg. Infect. Dis. 19:638-640(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000077};
CC   -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC       {ECO:0000256|ARBA:ARBA00007994}.
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DR   EMBL; JX941468; AGH10174.1; -; Genomic_DNA.
DR   Proteomes; UP000171699; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.270; -; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001462; DNApol_viral_C.
DR   InterPro; IPR000201; DNApol_viral_N.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   Pfam; PF00336; DNA_pol_viral_C; 1.
DR   Pfam; PF00242; DNA_pol_viral_N; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          364..605
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          196..234
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          264..315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        196..210
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        264..310
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   853 AA;  95233 MW;  B726DD528CA06B3A CRC64;
     MHPFSPLCRS IPSLGGEQGD ALLADPEEAL PLLADEDLNH RVAADLGLHL PTTVEPWVHK
     VGGLTGLYSE KPKSFNPEWK TPSFDNIHLR PDLIQYLQNR VGLNPNEKRR LRLCLPARFY
     PNKTKYFPLS KGIKNYYPEH TLTHFFHTSN YLWTLWEAGI TYLRESEKSA SFKGQLYPWE
     QKQLISHGTK LVHTQPVGIS SRTSTSKPLC PRLSGLGLKS GQRSMATSKG SVPGSLRARF
     CSPSWGPHGQ SALCPRRQLN LKQPRNHCLS NPKSQGRKPD PSYSITSATP HHNQSKEGAS
     TNSSYAPGQS HTPPFEHALL EGEVRSSHNC WWKQLQVADP CGDSCLSNIL GLIDDWGPCY
     RHGDHHIRIP RTPRRITGGV FLVDKNPGNR QESRLVVDFS QFSRGDTRVH WPKFAVPNLQ
     SLTNLLSTNM HWLSLDVAAA FYHIPLSSAA MCHLLVGSPG LEGLPTSVPL AHQLFNNNQM
     FHVHRHCNRS NYLALLLLFK TYGRKLHMLA HPYIMGFRKI PMGVGLSPFL LAQFTSALAS
     LVRRTFPHCM AFTYMDDVVL GAKSPHHLRA LHTSVCSLFR DLGIVVNPTK TKWWGKHLHF
     MGLIISPGGT LPQDKHHQKA LKLISSLPVN KPLDWKILQR ITGLLGFLAP FTTCGYPALM
     PLYHAITRRQ ALKISWPFKN FLYSLYKQPL PVIRQKPAIC QVFADATPTG WGLVNHSSAW
     LRQGRFPRPL PIHCAELIAA CLARRWTGAR VIGTDNSIVA SGKRTSFPWL LGCVANWMLR
     GTSFCFVPSA LNPADAPSRG MLGIPVAPPP LPFRPSTGRT SLFAVSPSVP PHLPDRVHFA
     SPVPTSRDAW RPP
//