ID M4Q7V8_HBV Unreviewed; 460 AA.
AC M4Q7V8;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=P {ECO:0000313|EMBL:AGH20304.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AGH20304.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AGH20304.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=13006 {ECO:0000313|EMBL:AGH20304.1};
RX PubMed=22711345; DOI=10.1002/jmv.23260;
RA Sa-Nguanmoo P., Tangkijvanich P., Tharmaphornpilas P.,
RA Rasdjarmrearnsook A.O., Plianpanich S., Thawornsuk N., Theamboonlers A.,
RA Poovorawan Y.;
RT "Molecular analysis of hepatitis B virus associated with vaccine failure in
RT infants and mothers: a case-control study in Thailand.";
RL J. Med. Virol. 84:1177-1185(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; KC315309; AGH20304.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 176..419
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 70..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGH20304.1"
FT NON_TER 460
FT /evidence="ECO:0000313|EMBL:AGH20304.1"
SQ SEQUENCE 460 AA; 51088 MW; 8D0AC75C45E80886 CRC64;
GRLVFQTSTR HGDEPFCSQS PGILSRSPVG PSVRSQFKQS RLGLQPQQGS MASGKPGRSG
IIRARVHSTP RQSFGVEPSG SGHIDNSASS TSSCLHQSAV RKTAYSHLST SKRQSSSGHA
VELQHIPPSS ARSQSERPIL SCWWLKFRNS KPCSDHCLSH IVNLLEDWGP CTEYGEHHIR
IPRTPARVTG GVFLVDKNPH NTTESRLVVD FSQFSRGSTH VSWPKFAVPN LQSLTNLLSS
NLSWLSLDVS AAFYHLPLHP AAMPHLLVGS SGLPRYVARL SSTSRNINYQ HGTMQDLHDS
CSRNLYVSLL LLYKTFGRKL HLYSHPIILG FRKIPMGVGL SPFLLAQFTS AICSVVRRAF
PHCLAFSYMD DVVLGAKSVQ HLEALFTSIT NFLLSLGIHL NPNKTKRWGY SLNFMGYVIG
SWGTLPQEHI VQKLKQCFRK LPINRPIDWK VCQRIVGLLG
//
