ID M4QAN1_HBV Unreviewed; 448 AA.
AC M4QAN1;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Protein P {ECO:0000256|ARBA:ARBA00021149};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE Flags: Fragment;
GN Name=P {ECO:0000313|EMBL:AGH20441.1};
OS Hepatitis B virus (HBV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX NCBI_TaxID=10407 {ECO:0000313|EMBL:AGH20441.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AGH20441.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M13007 {ECO:0000313|EMBL:AGH20441.1};
RX PubMed=22711345; DOI=10.1002/jmv.23260;
RA Sa-Nguanmoo P., Tangkijvanich P., Tharmaphornpilas P.,
RA Rasdjarmrearnsook A.O., Plianpanich S., Thawornsuk N., Theamboonlers A.,
RA Poovorawan Y.;
RT "Molecular analysis of hepatitis B virus associated with vaccine failure in
RT infants and mothers: a case-control study in Thailand.";
RL J. Med. Virol. 84:1177-1185(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000077};
CC -!- SIMILARITY: Belongs to the hepadnaviridae P protein family.
CC {ECO:0000256|ARBA:ARBA00007994}.
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DR EMBL; KC315344; AGH20441.1; -; Genomic_DNA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.270; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001462; DNApol_viral_C.
DR InterPro; IPR000201; DNApol_viral_N.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR Pfam; PF00336; DNA_pol_viral_C; 1.
DR Pfam; PF00242; DNA_pol_viral_N; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 176..419
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 65..89
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGH20441.1"
FT NON_TER 448
FT /evidence="ECO:0000313|EMBL:AGH20441.1"
SQ SEQUENCE 448 AA; 49551 MW; E24E7BC552A28959 CRC64;
GRLVFQTSAR HGDEPFCSQS SGILSRSPVG PGVRSQFKQS RLGLQPQQGS MASGKPGRSG
IIRARVHSTT RQSFGVEPSG SGHIDNSASS ASSCLHQSAV RKTAYSHLST SKRQSSSGHA
VELQHIPPSS ARSQSEGPIL SCWWLKFRNS KPCSDYCLSH IVNLLEDWGP CTEYGEHHIR
IPRTPARVTG GVFLVDKNPH NTTESRLVVD FSQFSRGSTH VSWPKFAVPN LQSLTNLLSS
NLSWLSLDVS AAFYHLPLHP AAMPHLLVGS SGLPRYVARL SSTSRNINYQ HGTMQDLHDS
CSRNLYVSLL LLYKTFGRKL HLYSHPIILG FRKIPMGVGL SPFLLAQFTS AICSVVRRAF
PHCLAFSYMD DVVLGAKSVQ HLESLFTAVT NFLLSLGIHL NPNKTKRWGY SLNFMGYVIG
SWGTLPQEHI VQKLKQCFRK LPINRPID
//
