ID M4QFX0_9HIV1 Unreviewed; 657 AA.
AC M4QFX0;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AGH17525.1};
OS Human immunodeficiency virus 1.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11676 {ECO:0000313|EMBL:AGH17525.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AGH17525.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=327c {ECO:0000313|EMBL:AGH17525.1};
RA McGuire A.T., Hoot S., Dreyer A.M., Lippy A., Stuart A., Cohen K.,
RA Jardine J., Menis S., Scheid J.F., West A.P., Schief W.R., Stamatatos L.;
RT "Engineering HIV envelope protein to activate germline B cell receptors of
RT broadly neutralizing anti-CD4 binding site antibodies.";
RL J. Exp. Med. 0:0-0(2013).
RN [2] {ECO:0000313|EMBL:AGH17525.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=327c {ECO:0000313|EMBL:AGH17525.1};
RA Sather D.N., Stuart A., Kraft Z., Ellingson K., Stamatatos L., Sellhorn G.;
RT "Immunogenicity of Clade C gp140 envelopes derived from breakthrough
RT infections in the HVTN503 Phambili Trial.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; KC769516; AGH17525.1; -; Genomic_DNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 2.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 2.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Viral envelope protein {ECO:0000313|EMBL:AGH17525.1};
KW Virion {ECO:0000313|EMBL:AGH17525.1}.
FT DOMAIN 29..137
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 141..484
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 504..656
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AGH17525.1"
SQ SEQUENCE 657 AA; 73975 MW; 521CD20F720F4CEF CRC64;
MDAMKRGLCC VLLLCGAVFV SPSASMGNLW VTVYYGVPVW KEAKTTLFCA SDAKAYEQEV
HNVWATHACV PTDPNPQEMR MENVTENFNM WKNDMVDQMH EDIISLWDQS LKPCVKLTPL
CVTLDCQNVN ATQNTNDTIS TMKNCTFNTT ADLGDKKQKG RALFYNLDIV QLNPNSNSSE
YRLISCNTST ITQACPKVSF EPIPIHYCAP AGYAILKCNN KTFNGLGPCT NVSTVQCTHG
IKPVVSTQLL LNGSLAEGEI IIRSENLTDN GKTIIVHLNE SVKIVCIRPN NNTRKSIRIG
PGQTFFATDI IGDIRQAYCN ISREDWNKTL DRVRKKLEEH FPNKTIEFKR HSGGDLEVTQ
HSFNCRGEFF YCNTTHLFEN TTYTNSSNIT LPCRIKQIIN MWQGVGRAMY APPIAGNITC
ISNITGILLT RDGGNNGTNE TFRPGGGDMR DNWRSELYKY KVVEIKPLGI APTKAKSSVV
ESEKSAVGMG ALFLGFLGAA GSTMGAASMT LTVQARQLLS GIVQQQSNLL RAIEAQQHML
QLTVWGIKQL QARVLALERY LQDQQLLGIW GCSGKLICTT AVPWNSSWSN KTYNDIWDNM
TWMQWEREIS NYTNTIYTLL EVSQNQQEQN EKDLLALDKW QNLWSWFNIT NWLWYIK
//
