ID   M4SM46_9SAUR            Unreviewed;       204 AA.
AC   M4SM46;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   RecName: Full=Brain-derived neurotrophic factor {ECO:0000256|ARBA:ARBA00022282, ECO:0000256|RuleBase:RU364086};
DE            Short=BDNF {ECO:0000256|RuleBase:RU364086};
DE   Flags: Fragment;
GN   Name=BDNF {ECO:0000313|EMBL:AGH55544.1};
OS   Corallus hortulanus (Garden tree boa).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Henophidia; Boidae; Boinae; Corallus.
OX   NCBI_TaxID=709348 {ECO:0000313|EMBL:AGH55544.1};
RN   [1] {ECO:0000313|EMBL:AGH55544.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Chort26 {ECO:0000313|EMBL:AGH55544.1};
RX   PubMed=23261714; DOI=10.1016/j.ympev.2012.11.027;
RA   Colston T.J., Grazziotin F.G., Shepard D.B., Vitt L.J., Colli G.R.,
RA   Henderson R.W., Blair Hedges S., Bonatto S., Zaher H., Noonan B.P.,
RA   Burbrink F.T.;
RT   "Molecular systematics and historical biogeography of tree boas (Corallus
RT   spp.).";
RL   Mol. Phylogenet. Evol. 66:953-959(2013).
CC   -!- FUNCTION: Promotes the survival of neuronal populations that are all
CC       located either in the central nervous system or directly connected to
CC       it. {ECO:0000256|ARBA:ARBA00002323, ECO:0000256|RuleBase:RU364086}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU364086}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00010783, ECO:0000256|RuleBase:RU364086}.
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DR   EMBL; JX244305; AGH55544.1; -; Genomic_DNA.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR020430; Brain-der_neurotrophic_factor.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589:SF12; BRAIN-DERIVED NEUROTROPHIC FACTOR; 1.
DR   PANTHER; PTHR11589; NERVE GROWTH FACTOR NGF -RELATED; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01912; BDNFACTOR.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Growth factor {ECO:0000256|RuleBase:RU364086}.
FT   DOMAIN          112..203
FT                   /note="Nerve growth factor-related"
FT                   /evidence="ECO:0000259|SMART:SM00140"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AGH55544.1"
FT   NON_TER         204
FT                   /evidence="ECO:0000313|EMBL:AGH55544.1"
SQ   SEQUENCE   204 AA;  22858 MW;  D3942E64B4B04457 CRC64;
     MKEVSIRGQG SLAYPGLRTQ GNLETLSGPN DATRGLTSLA DTFEHVIEEL LGEQQVIQPS
     KENKDADLYS TRVMLSSQVP LEPPLLFLLE EYKNYLDAAN MSLRVRRHSD PARRGELSVC
     DSTSEWVTAA EKKTAVDMSG ATVTVLEKVP VPKGQLKQYF YETKCSSKGY AKEGCRGIDK
     RYWNSQCRTT QSFVRALTMD DXKR
//