ID M4TV55_9XANT Unreviewed; 269 AA.
AC M4TV55;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase {ECO:0000313|EMBL:AGH77246.1};
DE EC=2.7.4.7 {ECO:0000313|EMBL:AGH77246.1};
GN ORFNames=XAC29_08810 {ECO:0000313|EMBL:AGH77246.1};
OS Xanthomonas axonopodis Xac29-1.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Xanthomonas.
OX NCBI_TaxID=1304892 {ECO:0000313|EMBL:AGH77246.1, ECO:0000313|Proteomes:UP000011979};
RN [1] {ECO:0000313|EMBL:AGH77246.1, ECO:0000313|Proteomes:UP000011979}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Xac29-1 {ECO:0000313|EMBL:AGH77246.1,
RC ECO:0000313|Proteomes:UP000011979};
RA Chen G., Zou H., Ye G., Song X., Ji Z., Ma W.;
RT "Completed genome of Xanthomonas axonopodis sp. Xac29-1.";
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-
CC amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP;
CC Xref=Rhea:RHEA:19893, ChEBI:CHEBI:30616, ChEBI:CHEBI:57841,
CC ChEBI:CHEBI:58354, ChEBI:CHEBI:456216; EC=2.7.4.7;
CC Evidence={ECO:0000256|ARBA:ARBA00000565};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-
CC methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+);
CC Xref=Rhea:RHEA:23096, ChEBI:CHEBI:15378, ChEBI:CHEBI:16892,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:58354, ChEBI:CHEBI:456216;
CC EC=2.7.1.49; Evidence={ECO:0000256|ARBA:ARBA00000151};
CC -!- PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004948}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP004399; AGH77246.1; -; Genomic_DNA.
DR RefSeq; WP_015463084.1; NC_020800.1.
DR AlphaFoldDB; M4TV55; -.
DR KEGG; xao:XAC29_08810; -.
DR PATRIC; fig|1304892.4.peg.1889; -.
DR HOGENOM; CLU_020520_0_1_6; -.
DR UniPathway; UPA00060; UER00138.
DR Proteomes; UP000011979; Chromosome.
DR GO; GO:0008902; F:hydroxymethylpyrimidine kinase activity; IEA:RHEA.
DR GO; GO:0008972; F:phosphomethylpyrimidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009228; P:thiamine biosynthetic process; IEA:InterPro.
DR GO; GO:0009229; P:thiamine diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd01169; HMPP_kinase; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR InterPro; IPR004399; HMP/HMP-P_kinase_dom.
DR InterPro; IPR013749; PM/HMP-P_kinase-1.
DR InterPro; IPR029056; Ribokinase-like.
DR NCBIfam; TIGR00097; HMP-P_kinase; 1.
DR PANTHER; PTHR20858:SF17; HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED; 1.
DR PANTHER; PTHR20858; PHOSPHOMETHYLPYRIMIDINE KINASE; 1.
DR Pfam; PF08543; Phos_pyr_kin; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:AGH77246.1};
KW Transferase {ECO:0000313|EMBL:AGH77246.1}.
FT DOMAIN 16..255
FT /note="Pyridoxamine kinase/Phosphomethylpyrimidine kinase"
FT /evidence="ECO:0000259|Pfam:PF08543"
SQ SEQUENCE 269 AA; 28018 MW; C6ADDD7D7A43AAE5 CRC64;
MTTPSTLSAL SIAGSDSGGG AGIQADLKTF AAHRVHGLSA IAALTAQHTR AVTAVHIPPL
PFLQAQVDAC FADFEIQAVK LGMLANADII HCVADLLERY RPPFVVLDPV MVSTSGARLL
EDAALDALRT RLLPLATLVT PNTPEAELLT GHRIDSADAA EHATAALLDL GANAVLLKGG
HLHEGARVLD RFDDGVTQDV FMHPRLQVDA HGTGCSLSAA IAAQLCQGLS LLNACEAAID
YVARAIRIGQ RPGQSDVLVL DHFGAARGA
//
