ID M5V0Z8_9LEPT Unreviewed; 848 AA.
AC M5V0Z8;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Negative regulator of genetic competence ClpC/MecB {ECO:0000313|EMBL:EMI67194.1};
GN Name=clpC {ECO:0000313|EMBL:EMI67194.1};
GN ORFNames=LEP1GSC076_1465 {ECO:0000313|EMBL:EMI67194.1};
OS Leptospira sp. Fiocruz LV4135.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1193013 {ECO:0000313|EMBL:EMI67194.1, ECO:0000313|Proteomes:UP000011956};
RN [1] {ECO:0000313|EMBL:EMI67194.1, ECO:0000313|Proteomes:UP000011956}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fiocruz LV4135 {ECO:0000313|EMBL:EMI67194.1,
RC ECO:0000313|Proteomes:UP000011956};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Ko A.I., Reis M.G., Ribeiro G.S., Wunder E.Jr.,
RA Vinetz J.M., Sutton G.G., Nierman W.C., Fouts D.E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMI67194.1}.
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DR EMBL; AOHI01000037; EMI67194.1; -; Genomic_DNA.
DR RefSeq; WP_008399618.1; NZ_AOHI01000037.1.
DR AlphaFoldDB; M5V0Z8; -.
DR PATRIC; fig|1193013.3.peg.1560; -.
DR Proteomes; UP000011956; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.8.60; -; 2.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001943; UVR_dom.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF193; CHAPERONE PROTEIN CLPB; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 2.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SMART; SM01086; ClpB_D2-small; 1.
DR SUPFAM; SSF81923; Double Clp-N motif; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51903; CLP_R; 1.
DR PROSITE; PS00870; CLPAB_1; 1.
DR PROSITE; PS50151; UVR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|PROSITE-
KW ProRule:PRU01251}.
FT DOMAIN 1..145
FT /note="Clp R"
FT /evidence="ECO:0000259|PROSITE:PS51903"
FT DOMAIN 431..466
FT /note="UVR"
FT /evidence="ECO:0000259|PROSITE:PS50151"
FT REGION 151..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 46..102
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 427..484
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 151..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 848 AA; 95333 MW; 5915E07535C1CC52 CRC64;
MLEFTKRAKR VINEIAQDEA KRLGSDYIGP EHILLGLLKE EDSVAIKILN NLNINLNELR
KEVERRTREA SGTLLMDVAG GQDRYQKIIE LSKEEAKRLK HNYVGTEHIL LALLRDNNNI
AGGALYSFSV NYNVIKSEIL RLLGAPPTSS VGVSSAAQSG SQGAQQSRQE KTKTPILDEF
ARDLTQLARD KKLDPVVGRA TEIQRVIQIL SRKTKNNPVL VGESGVGKTA IVEGLALAIV
EKSVPDLLFE KRVLSLDLAS LIAGTKYRGE FEERLKKIMK EITSSTNIII FIDELHTLIG
AGAAEGAVDA ANILKPALAR GELQCIGATT SAEYRKYIEK DSALERRFQV VKVAEPSVSD
AIQILQGLKK AYEAHHKVRY SDKALEQSVK LSHRYINDRY LPDKAIDIID EAGAKARLAN
CARPQTIKDL EEEIKSLASK KEELVRAQEY EKAAGVRDEV NRKRQAMEEK IRAWQEKMED
FAVNIDEDDI LSVVSLWTGI PLEKMEESES DKLLRLEDEL KKRVVGQEEA IEKIAKAVRR
ARTGFKSERR PTGSFIFLGP TGVGKTELAK ALANFLFGND DAMLRVDMSE YMEPHAVSRL
IGAPPGYVGY DDGGQLTEFV RKRPYSIILL DEIEKAHHDI FNILLQIMEE GNLTDTKGRK
VNFRDTIIIM TSNIGAKEIQ AGGRLGFEDR KDEALKYKSD QTRDQLKKYF NPEFLNRVDE
VIYFGSLTKE NIMSIIDIMV IDTNKRLREK TIQVSITQAA KDHIMDIGYD EKFGARPLRR
VFQRELEDHM AIQTLKGAYK EPTKIEIDFK EGKLEFIETS WADYKPAEAG GDDNSSGNPE
RSEEIALV
//
