ID M5X749_PRUPE Unreviewed; 469 AA.
AC M5X749;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Legumain prodomain domain-containing protein {ECO:0000259|Pfam:PF20985};
GN ORFNames=PRUPE_3G024900 {ECO:0000313|EMBL:ONI15084.1};
OS Prunus persica (Peach) (Amygdalus persica).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Amygdaloideae; Amygdaleae; Prunus.
OX NCBI_TaxID=3760 {ECO:0000313|EMBL:ONI15084.1, ECO:0000313|Proteomes:UP000006882};
RN [1] {ECO:0000313|EMBL:ONI15084.1, ECO:0000313|Proteomes:UP000006882}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nemared {ECO:0000313|Proteomes:UP000006882};
RX PubMed=23525075; DOI=10.1038/ng.2586;
RA Verde I., Abbott A.G., Scalabrin S., Jung S., Shu S., Marroni F.,
RA Zhebentyayeva T., Dettori M.T., Grimwood J., Cattonaro F., Zuccolo A.,
RA Rossini L., Jenkins J., Vendramin E., Meisel L.A., Decroocq V.,
RA Sosinski B., Prochnik S., Mitros T., Policriti A., Cipriani G., Dondini L.,
RA Ficklin S., Goodstein D.M., Xuan P., Del Fabbro C., Aramini V., Copetti D.,
RA Gonzalez S., Horner D.S., Falchi R., Lucas S., Mica E., Maldonado J.,
RA Lazzari B., Bielenberg D., Pirona R., Miculan M., Barakat A., Testolin R.,
RA Stella A., Tartarini S., Tonutti P., Arus P., Orellana A., Wells C.,
RA Main D., Vizzotto G., Silva H., Salamini F., Schmutz J., Morgante M.,
RA Rokhsar D.S.;
RT "The high-quality draft genome of peach (Prunus persica) identifies unique
RT patterns of genetic diversity, domestication and genome evolution.";
RL Nat. Genet. 45:487-494(2013).
CC -!- SIMILARITY: Belongs to the peptidase C13 family.
CC {ECO:0000256|ARBA:ARBA00009941}.
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DR EMBL; CM007653; ONI15084.1; -; Genomic_DNA.
DR RefSeq; XP_007216154.1; XM_007216092.1.
DR AlphaFoldDB; M5X749; -.
DR STRING; 3760.M5X749; -.
DR EnsemblPlants; ONI15084; ONI15084; PRUPE_3G024900.
DR GeneID; 18783417; -.
DR Gramene; ONI15084; ONI15084; PRUPE_3G024900.
DR KEGG; pper:18783417; -.
DR eggNOG; KOG1348; Eukaryota.
DR HOGENOM; CLU_024160_0_0_1; -.
DR OMA; GHFQILV; -.
DR OrthoDB; 2951493at2759; -.
DR Proteomes; UP000006882; Chromosome g3.
DR GO; GO:0005773; C:vacuole; IEA:GOC.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0051603; P:proteolysis involved in protein catabolic process; IBA:GO_Central.
DR GO; GO:0006624; P:vacuolar protein processing; IBA:GO_Central.
DR CDD; cd21115; legumain_C; 1.
DR Gene3D; 1.10.132.130; -; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR InterPro; IPR043577; AE.
DR InterPro; IPR048501; Legum_prodom.
DR InterPro; IPR046427; Legumain_prodom_sf.
DR InterPro; IPR001096; Peptidase_C13.
DR PANTHER; PTHR12000; HEMOGLOBINASE FAMILY MEMBER; 1.
DR PANTHER; PTHR12000:SF53; VACUOLAR-PROCESSING ENZYME-LIKE; 1.
DR Pfam; PF20985; Legum_prodom; 1.
DR Pfam; PF01650; Peptidase_C13; 1.
DR PIRSF; PIRSF500139; AE; 1.
DR PIRSF; PIRSF019663; Legumain; 1.
DR PRINTS; PR00776; HEMOGLOBNASE.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000006882};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 367..463
FT /note="Legumain prodomain"
FT /evidence="ECO:0000259|Pfam:PF20985"
FT ACT_SITE 171
FT /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
FT ACT_SITE 214
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR019663-1"
SQ SEQUENCE 469 AA; 52333 MW; 3A8CF81492FAF226 CRC64;
MAILSCGVLL SLALLSLSIG INLCLPENGK EIDFSAHGEN ASPSTTKKDK GKRWAVLIAG
SNGYYNYRHQ ADICHAYQIL KKGGLKDENI IVFMYDDIAH DPENPRQGVI INKPKGHDVY
KGVPKDYTGA DVNSKNFYAV ILGNKRNLTG GSGKVLKSGP NDHVFIYYAD HGSAGLLGMP
SGDDAVYAKD LIHVLKKKHA SKGFKSMVFY VEACESGSIF EGLLPNKMNI YATTAANAEE
SSYGTYCPGE PEVPEEYDTC LGDLYSISWL EDCDSNDLRK ETLEKQYERV RRRTNKSHVM
QYGDMSHRKE FLFTYMGADL ANDSYTSIGD ISSPSRAVNQ RDTNLLYFQH KFLRAPAGSH
AKLEARKQLL HEIAHRKHVD YSIHKIGELL FGYQKSSNVL MNGRPQGQPV VDDWDCFKKF
LRIYKNYCGH LSTYGMKYTR AIANICNAGV TLEKMVAASD QACSKKLHV
//
