ID M6CWY1_9LEPT Unreviewed; 2515 AA.
AC M6CWY1;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Virulence plasmid 65kDa B protein {ECO:0000313|EMBL:EMJ93443.1};
GN ORFNames=LEP1GSC194_2330 {ECO:0000313|EMBL:EMJ93443.1};
OS Leptospira alstonii serovar Sichuan str. 79601.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1218565 {ECO:0000313|EMBL:EMJ93443.1, ECO:0000313|Proteomes:UP000011988};
RN [1] {ECO:0000313|EMBL:EMJ93443.1, ECO:0000313|Proteomes:UP000011988}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=79601 {ECO:0000313|EMBL:EMJ93443.1,
RC ECO:0000313|Proteomes:UP000011988};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Galloway R.L., Vinetz J.M., Sutton G.G.,
RA Nierman W.C., Fouts D.E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMJ93443.1}.
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DR EMBL; ANIK01000066; EMJ93443.1; -; Genomic_DNA.
DR PATRIC; fig|1218565.3.peg.3080; -.
DR Proteomes; UP000011988; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.40.128.340; -; 2.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR031325; RHS_repeat.
DR InterPro; IPR003284; Sal_SpvB.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR NCBIfam; TIGR01643; YD_repeat_2x; 1.
DR PANTHER; PTHR43032; PROTEIN-METHIONINE-SULFOXIDE REDUCTASE; 1.
DR PANTHER; PTHR43032:SF3; PROTEIN-METHIONINE-SULFOXIDE REDUCTASE CATALYTIC SUBUNIT MSRP; 1.
DR Pfam; PF05593; RHS_repeat; 1.
DR Pfam; PF03534; SpvB; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 570..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1424..1464
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2515 AA; 278114 MW; A19AB1CA83C7459B CRC64;
MKNSEKPTNK AILYTNILLF FCILVCTTSC GLIPGKNGKN NNWWMALAGL VPGTSFPSSG
SGVGSGNGGP GSAPAPEGSD LFSISTNYSS AIDDPDTKAE PHAGAAFIAP PEPGHYGTVN
LTYPIHTPSG RAGVEPKLSL SYSSTGGDGW LGVGWSLSLG SITRTPEYGA LWYDARDTFT
WNGQRLVKVA GGTTNENGTY RPEIASEDLV VLRLSNIESG GVWEVLDSTG TKTVFGESTS
SRIFNPQVPN QTYSWYLTRT EDKNGNYLQV HYDNSEYSNT RNLYLKEIRY TGNSKSGVSA
RQYVKFITKQ RDDFYVSNAP GFLMKMDKIL ERIEVGWDNA GKLYDYTPIY ETSSDSGRPR
LKNIQSSRHT TSPEFEYQSS SRYLIWQNVV NQTSSETEDD PNSTQYFEGD FNGDGISDIL
FFNPKSGNWK AAEGRKEGGY NFKLYANRYQ GYNTQEKVQF FKGNVSGDYN GNGRSDIAFY
LPETRDFIVA EHDGRVFQFR SYGRLMAGIP DIFRMEWFPG DYDGNGLSDS VLFDEPTGQW
TLMLNKGGSF EFLRFAKKFQ NVFRGDYSPD GNLDSSSTND SSKPGKDHDK VNFLVGDYNG
DGRTDISLYD SRSGKWFVGE NHRNPNKNDS VYFQMQWKLY KVFTAPEQAL FGHDRFSGDF
NGDGLSDFLL FDRSNGEWTL GETGDGTINF KIWSRTPQFK PVTRWLQGDF NGDGRTDIGF
YSASDGKFWI GESTQNGFRY KVYSDLSYGP DQDRILKTPL PKDEVKIESG KTSFTAASNT
KTILLSYKYD GNLNSGKGEL VFPGCFTQDD CSNSPELLIY DRKANVFDLK QGNTFTERVN
TSLNPEGTGI TTLLGGKPDR YTNNTKGEVL FYKKQGNTNQ FFVLKHTNGT AFDISNLATF
TDTDVTKFDP LNSGTVVDHF ENNTSQSVLI LDDQTTNGNA RFVLSGLGGT KVLTPSGDLT
ATDLNDLFQA GTNENRQRRK EFSLFSGKFT STQAQLVIVD RRTTVHKWYL GTINANAIQF
KRLTGDIALP ITTSDYNSAS PAGIVYALTS DGSIVFGKTL DNGTSFYKVK VNATSVSRTL
YNAGTVGFSD RFDSGGNPIL LSGGEDKLYD LAQSKIVTLP GNVVVKNLDR PDLTSQVYVF
RWIQGDYNGD GLTDIGIFHL KEPTWYFALS TGSVPDIIER VKNGIGGIYE FEYSNSTKFD
NTGDDDIPDL PTSYRVCTKV TIDDGFSNRV AKSYEYKNGF AFSSFVDGKK ETDYFGFSEF
TVHEAYGERT THKYHTTPYS DFLMNRALSG AEKETKIVGN DNNDYGTIQT TYDLKQIAIA
PGVTSYLPVT TKIEKFLSGS RTTTQSSDIV ISGTKISRKT DTTTDHFTDT VHGVTTTTSI
IDFETDDTTN QRRATRSVTF SGSSHEITSL LSYDTRGNVT KRVSSYTGSG LSPVGSHTTE
YETDNHGNQT LEKDTSSSPA RGTSYTYDNE LQQFVTQETK FGGSISFTTT HQIGYGPAFG
LPATTTDPNG NKSYFEYDNF GRLIRASADT DDGTRTISTH SYDSSFPLSA KTILPSGTGD
PDFASRTYSD GMGRNIYTVK SASNAGYVLT GRLVYDGTGK IIRKGQSNWA TSGEIDRFVL
HLEERNPTSF EYDPIGRVKK TILPTAGGET SPTTITTTYN SAFETTENHS SGTSKRTVKD
AKGEILYVED FASDGTQAKI GFCYDIAGNR TKKSDLNDSS LMSCPNASAG VPTKDVSGKN
QATWSYDAFG KLRAESDPDL GVSSYNYNAF GDLTSQTNAK GVTTTLSYDG VGRITTKNIP
EGNIQYVYDS LSGSENALGK LVRVEDSNQN KTFSYDKLGR VKKETRVILA TSAGNPLPSE
TQGPYITETK YDLLGRVTRI DYPEHPISHG RMRACYEYGT AGYISGISVQ VNTNGILPGY
CNKDIVENIT YNEFGQTAGF TLGNGIATSY GYDVKGRMVR LNSSGDVDGS NKVLQDAVYS
FNPNNNITRI ANNSTDWNAQ YDYDYDGIGR LTNAVGIHVE TTESNLTKRF QQSYSYAKNG
NLTSKRIHDP ASGNVTDDWS YLYSNHQVTN IDSSKSGNDT LVMQYDANGN LTRQRDNAKD
LTKRISVDSQ DRIVQIQDGN NATLGTYWYD EGGFRIRKSS LEPKNNQFAN TEILYPSKFY
GLEFIEAENV LTSVNNIYLN GVRVAAMNEA GALAYFLTDQ VDSVSHVLDD EGKTLSKMQY
LPYGEMFVQR GDTNFSPKYN SQELDRESGF YFYNARYYDP GIARFTSADT IIDGEFDTQG
WNRFSYVKGN PIGAKDPTGH EIFTVAREYS NTHVPRAAET TGKNIYLVEK NDVKSGLGLS
QLAEKALSYE GKNTTNESVK KKMQEILENN PNAFGKNKTL KANSRVEVGK YQGPNPNAPN
IFDSMIGSPG KALKALKYGG SYAYNKATGK DNETEEIKQS KTKVNANSEK IFNQYENRLQ
KLGAETRTKG FPFNLYGEEG KPAFKPDVNS NGNLMFKGYQ GEVITTNEKA AKINK
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