ID M6F1J4_9LEPT Unreviewed; 330 AA.
AC M6F1J4;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 39.
DE SubName: Full=HpcH/HpaI aldolase/citrate lyase family protein {ECO:0000313|EMBL:EMK22638.1};
GN ORFNames=LEP1GSC008_3506 {ECO:0000313|EMBL:EMK22638.1};
OS Leptospira kirschneri serovar Bulgarica str. Nikolaevo.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1240687 {ECO:0000313|EMBL:EMK22638.1, ECO:0000313|Proteomes:UP000011980};
RN [1] {ECO:0000313|EMBL:EMK22638.1, ECO:0000313|Proteomes:UP000011980}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nikolaevo {ECO:0000313|EMBL:EMK22638.1,
RC ECO:0000313|Proteomes:UP000011980};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Galloway R.L., Vinetz J.M., Sutton G.G.,
RA Nierman W.C., Fouts D.E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMK22638.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ANCE01000163; EMK22638.1; -; Genomic_DNA.
DR RefSeq; WP_004754013.1; NZ_ANCE01000163.1.
DR AlphaFoldDB; M6F1J4; -.
DR GeneID; 34316559; -.
DR PATRIC; fig|1240687.3.peg.3351; -.
DR OrthoDB; 8481499at2; -.
DR Proteomes; UP000011980; Unassembled WGS sequence.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 6.10.140.960; -; 1.
DR Gene3D; 3.20.20.60; Phosphoenolpyruvate-binding domains; 1.
DR InterPro; IPR005000; Aldolase/citrate-lyase_domain.
DR InterPro; IPR040186; Citramalyl-CoA_lyase.
DR InterPro; IPR011206; Citrate_lyase_beta/mcl1/mcl2.
DR InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR InterPro; IPR040442; Pyrv_Kinase-like_dom_sf.
DR PANTHER; PTHR11105:SF0; CITRAMALYL-COA LYASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11105; CITRATE LYASE SUBUNIT BETA-RELATED; 1.
DR Pfam; PF03328; HpcH_HpaI; 1.
DR PIRSF; PIRSF015582; Cit_lyase_B; 1.
DR SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
PE 4: Predicted;
KW Lyase {ECO:0000313|EMBL:EMK22638.1};
KW Magnesium {ECO:0000256|PIRSR:PIRSR015582-2};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR015582-2}.
FT DOMAIN 51..243
FT /note="HpcH/HpaI aldolase/citrate lyase"
FT /evidence="ECO:0000259|Pfam:PF03328"
FT BINDING 87
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR015582-1"
FT BINDING 152
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR015582-2"
FT BINDING 152
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR015582-1"
FT BINDING 178
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR015582-2"
SQ SEQUENCE 330 AA; 37078 MW; A1598DD6C8F26BCE CRC64;
MSKLTHPREA LFEGEKPFPI IPACEHFAGS EKLITKALEL QNKLGGLFDI TMDCEDGAQT
GKEKEHAELI VRLQNSELNK HKMSGVRIHD YTNSFWKQDV DIIVPGAGEK IAYITIPKPT
RAAQVEEMIT YIQKAVQKAG IKREIPIHVL IETNGALQEV EKIAALPWLQ VLDFGLMDFI
SGHHGAIPAS CMKSPGQFEH ELLRRGKANL VAAALANGVI PAHNVTLDLK NQYQTYKDAK
RAHDDFGFLR MWSIYPTQIQ AILDAMAPDY SEVQTSAEIL IQAQNAEWGP IQYAGDLHDR
ATYRYFWEIL QKAKLTGISI PEEANKRFFS
//
