ID M6FN49_9LEPT Unreviewed; 2246 AA.
AC M6FN49;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=RHS repeat-associated core domain protein {ECO:0000313|EMBL:EMM73895.1};
DE Flags: Fragment;
GN ORFNames=LEP1GSC038_2127 {ECO:0000313|EMBL:EMM73895.1};
OS Leptospira weilii str. 2006001855.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=996804 {ECO:0000313|EMBL:EMM73895.1, ECO:0000313|Proteomes:UP000012101};
RN [1] {ECO:0000313|EMBL:EMM73895.1, ECO:0000313|Proteomes:UP000012101}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=2006001855 {ECO:0000313|EMBL:EMM73895.1,
RC ECO:0000313|Proteomes:UP000012101};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Hospenthal D.R., Murray C.K., Pimentel G.,
RA Wasfy M., Vinetz J.M., Sutton G.G., Nierman W.C., Fouts D.E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMM73895.1}.
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DR EMBL; AFJM02000022; EMM73895.1; -; Genomic_DNA.
DR Proteomes; UP000012101; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR031325; RHS_repeat.
DR InterPro; IPR003284; Sal_SpvB.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR PANTHER; PTHR32305; -; 1.
DR PANTHER; PTHR32305:SF15; PROTEIN RHSA-RELATED; 1.
DR Pfam; PF05593; RHS_repeat; 1.
DR Pfam; PF03534; SpvB; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..2246
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004077182"
FT TRANSMEM 1838..1857
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1869..1889
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2194..2212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2217..2236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EMM73895.1"
SQ SEQUENCE 2246 AA; 245515 MW; 0CC33F88B8994C28 CRC64;
ALALLIVSSS IAAFPFLQMF SLAGPSSETG IPQPLPEVVV DSFGAVNASI PIQVPKGTKD
ITPSIELQYN SFQNDGLVGG GWDLSGILTI SIDPSKGIHN DGNDAYVSFA GKLIQTSPNV
YHTKIESFFQ FKKLSDSWVA QDRNGTSYYF GEDATSENPN SNATIRNLSG NSRIWALNRV
RDLHGNGYNI KYQPYSSSNG TPIPDRIEYN QGNTVILFDI EDRTDAVESN FLNIQAKLTK
RIRSISVTQK QDNGTVTESE KYTLNYNNNL FDKKNRLVGV DRKNYGPIAF NYNNDSPTAG
STSKSSPSAI DMSYRFENSA IKSDCDFAAL VCACSADATC MAISGGFAGL ACWGYMDSIG
DMCVNGMVGS QTLLATFNPR KAPEPVWISG NKQSNQLVRY DSSNPGATSP IGGKTFTFNE
KSKVFQGDID GDLVSDFIAL ENDNVELNMS LSLAGSSFNP IGILTILKSN PNSYQGLVDL
NADGKSDFIQ TDASNNFQIY LASGGTLNTN PITLAIPGIG SSFRQFVDMD NDGIADYVRM
TDNPDGSKNL SISFLRYSGG NFSIRTTTSS YIGVSGTEGD RFLADSNGDG YLDLITFSAD
NNLYVYLSDG HVVRSPLAFP VSYTMPYYEV SSSIANSKRY SMRDMNWDGA ADRISLINNG
FQIDLYNPST LSFDTTFEVS SDGNQVKQFD VNWDGTLDSI SFYTFFFQGT GFHVKNGSDD
SNTDVVFDYN ETVPVPPNPA LMASDSAKVY SNFVNTKTFS DVDGDGKADF IRFQNGTIYV
SYSRSKNNSL FYSNGGDVSF PAASFSVAMD TNQDGRSDFI GFRGSMRNLV NDTFVNNLHS
FERNSTAHSN TLNIDYLEPS YSKKISQGLL TDILSVQEKG IQISYANTYD SSNSSVVNAI
NTSSIGAFLK PNLAPYSVAT NVYSQVANGI GESESYIFEN GKTYIQDQDN RSMMGFAKIT
IANSRTGEKN ISLYQGTNPN FAGLETKRDN YLNNNLISSI TSTFVSLSSP FGTVNVRKSQ
EVNTKYQDNA LLSTSQADYT YDSYNNILSK VTQIDGNASL TLREDNIYNP SLADWVLSEI
IQKRKSKGGN VASQVEIIYS NHMPADVKTL LKAGTTEYSV QTMLSYDSYG NPTSIREASG
NINLIEYDSI AHTYATRITN SLGIQIQKSY DYVFGSELTN IDPNGNRSEK LYDFYGRLIG
VKYPGESDWS EVVEYIQTGS PSGEKVKKTI QDSKTGNSWI QETHDAYGQV IRAESLAADA
IVIIEDRSYY SNGLLKNKTE PYIGVTPFLT STYLYDSENK VITISDTAGK KVDFVYSGFS
TDTVTTVNAN QINSLSVTKN ALGELLSKME NGKTIQYAYN SNSKTTQIRD PEGKNVNFAY
NLLGQKLSQS TVDTGSTTFQ LSPSGKVQEQ RNANGSYTTY QYDALDRVIR IVGNNASGTK
TIQLNYDESG VTNGVGRITS ITDSIGKTDF QYDVRGNQTK IRKYLNQEDL TLIFLKEYDL
GNRVTNLTYP NGTVLHNQYT PAGYLTSITM DSADGSSSGQ PVVNYIGPLI EGGKFKVQRT
VGNGVQTNIY FDPINRRPTE IVTGIDSDVY ESLKYDYDLS GNITKIEDLK NPGRTQNFQY
DAFNRLTNAN GKYGTEDYQY SDTGNLIKKG PSTYSYSGSN LHAVTQIVSP QGTKTYSYDS
SGLMTNRDGD VLEYSPMGKL QRMITKDGET FTYDYDYKGS RVRKSKQSDG TSVVSLDGDY
EISFRPGSSP LHTLYIKGLG GDIVSQLSLE NVGLLTNAQF ETENQSNVAG MLIHPKDSLC
KGVAKDCGNY YKNKTYDLYL SGIEVLFAAR NGRIGNQFRL TMISLFGICL MGFIGLSITK
SKSFQGFELA KVGITPILLL SVFMGFNFYS CGLLPGTGNK NGDPPWVVFP STIPTDTPSV
SNPGVGSGGG NIGGTPVPGM IFFHPNHLGS ISMATNGAGK PISGGSAIGT SFVSYKPYGE
ILRTDSYGPD VFRNKYTGQE EDKETGLLYY KSRYYDPAIA RFLQADSVVN GDSASGSNLY
MYVEGNPLSY RDPGGQINIW HMFMEIIKHM AGGITLAAKA LDGTLRAIGR SIDHIGRAIA
RSADHIGRTI AHSVDHTWRP ILKNIDKGAR EVLKNVDHSA REMFKNVDKA AREMGRGIDG
EVRVILSGGK YSRNSSTRDY SLEHSDLVKW VESWNGTMII GGAIMIIIGA VFGQPEFIVW
GIMTVIAGIT GADFGIETSG GTEGAG
//
