ID M6Q5Y5_9LEPT Unreviewed; 791 AA.
AC M6Q5Y5;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Bacillolysin family protein {ECO:0000313|EMBL:EMN88118.1};
GN ORFNames=LEP1GSC108_0904 {ECO:0000313|EMBL:EMN88118.1};
OS Leptospira weilii str. UI 13098.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1088542 {ECO:0000313|EMBL:EMN88118.1, ECO:0000313|Proteomes:UP000012118};
RN [1] {ECO:0000313|EMBL:EMN88118.1, ECO:0000313|Proteomes:UP000012118}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UI 13098 {ECO:0000313|EMBL:EMN88118.1,
RC ECO:0000313|Proteomes:UP000012118};
RA Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA Sanka R., DePew J., Purushe J., Chanthongthip A., Lattana O.,
RA Phetsouvanh R., Newton P.N., Vinetz J.M., Sutton G.G., Nierman W.C.,
RA Fouts D.E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M4 family.
CC {ECO:0000256|ARBA:ARBA00009388}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMN88118.1}.
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DR EMBL; AHNU02000087; EMN88118.1; -; Genomic_DNA.
DR RefSeq; WP_004504372.1; NZ_AHNU02000087.1.
DR AlphaFoldDB; M6Q5Y5; -.
DR Proteomes; UP000012118; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09597; M4_TLP; 1.
DR Gene3D; 3.10.170.10; -; 1.
DR Gene3D; 3.10.450.490; -; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR InterPro; IPR011096; FTP_domain.
DR InterPro; IPR045474; GEVED.
DR InterPro; IPR023612; Peptidase_M4.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR InterPro; IPR001570; Peptidase_M4_C_domain.
DR InterPro; IPR013856; Peptidase_M4_domain.
DR PANTHER; PTHR33794; BACILLOLYSIN; 1.
DR PANTHER; PTHR33794:SF1; BACILLOLYSIN; 1.
DR Pfam; PF07504; FTP; 1.
DR Pfam; PF20009; GEVED; 1.
DR Pfam; PF01447; Peptidase_M4; 1.
DR Pfam; PF02868; Peptidase_M4_C; 1.
DR PRINTS; PR00730; THERMOLYSIN.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 7..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 112..143
FT /note="FTP"
FT /evidence="ECO:0000259|Pfam:PF07504"
FT DOMAIN 290..455
FT /note="Peptidase M4"
FT /evidence="ECO:0000259|Pfam:PF01447"
FT DOMAIN 460..629
FT /note="Peptidase M4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02868"
FT DOMAIN 702..785
FT /note="GEVED"
FT /evidence="ECO:0000259|Pfam:PF20009"
FT ACT_SITE 449
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
FT ACT_SITE 541
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
SQ SEQUENCE 791 AA; 89328 MW; 0A4FF5A1F7ADB9B4 CRC64;
MKYFDWFVYK KIGIISIWVF SSFIFLSCRD GKQIEFPYWL GILNPVSIDS KAISERQYSP
NGSLTFARFN SDLVPYSRQQ APEVLKAYLQ ISPESQPLLL RSNRYADRIY DRFQQYYKNI
KVENGIYTIE SKDNTIESMS GNFSEVPSDL ITTPSLSETD ALSKALKHFG AKKYIWESPE
REEMLKTIKK DSKATYFPKG ELLISKLSGL QKNEFRLVYR FGIAAIEPSA SKYIHVDANS
GEILASKDAR RYEAGEPGPT PQPPPDPNYG ICFPDKTPCI KTGSAATRFS GVQSIITWTA
GKDNYYELKD YSRGKGIFTY SWGFVDLGHG NESHKFPFSD SNNIWTSSEY HDDFNHDALF
DAHWGIEKTY DYFKVVHNRL SYDGNDGNVA NNVHYFDFAI TNNAYWDDVT EELFYLYCPH
NNSVCQDSGG NFMDPRFEDM TSLDFVSHEY GHGVTAYTSG WGYEKESGAL NEGFSDIWNI
AVNHFVNKTL GMHKNIWLFG DETAPGGGIR SAQNPRSTGL ISIGPTTYKG LFWDFETEKV
HINSTVLSHW FYILSNGKQG TNDHKCEYDA SGISIEKAEK IAYGTLLSLW PTSEYSDVRS
ASIAVSKYLY GKFSQEVKST IDAWDAVGVP ANTTSQGGLG MKPKHFITSV KLSNLERNSG
NDCGYRDSTY LRSTVLKGVT YNIQLSSQNS STDMFPTRTH KWKVWIDFNR DGIFDDGANS
TELVVQDSVS VSTEGNIQKS FIVPANALTG DTRMRVSMKA STSSEGYPRS DEKFIEGEVE
DYTITIRSLT F
//
