ID   M6YZF7_9LEPT            Unreviewed;      2363 AA.
AC   M6YZF7;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=RHS repeat-associated core domain protein {ECO:0000313|EMBL:EMO97221.1};
GN   ORFNames=LEP1GSC120_0978 {ECO:0000313|EMBL:EMO97221.1};
OS   Leptospira santarosai str. 200702252.
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=1049977 {ECO:0000313|EMBL:EMO97221.1, ECO:0000313|Proteomes:UP000012145};
RN   [1] {ECO:0000313|EMBL:EMO97221.1, ECO:0000313|Proteomes:UP000012145}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=200702252 {ECO:0000313|EMBL:EMO97221.1,
RC   ECO:0000313|Proteomes:UP000012145};
RA   Harkins D.M., Durkin A.S., Brinkac L.M., Haft D.H., Selengut J.D.,
RA   Sanka R., DePew J., Purushe J., Picardeau M., Werts C., Goarant C.,
RA   Vinetz J.M., Sutton G.G., Nierman W.C., Fouts D.E.;
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMO97221.1}.
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DR   EMBL; AHOA02000032; EMO97221.1; -; Genomic_DNA.
DR   Proteomes; UP000012145; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.180.10.10; RHS repeat-associated core; 3.
DR   InterPro; IPR028994; Integrin_alpha_N.
DR   InterPro; IPR022385; Rhs_assc_core.
DR   InterPro; IPR031325; RHS_repeat.
DR   InterPro; IPR003284; Sal_SpvB.
DR   InterPro; IPR006530; YD.
DR   NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR   NCBIfam; TIGR01643; YD_repeat_2x; 2.
DR   PANTHER; PTHR32305; -; 1.
DR   PANTHER; PTHR32305:SF15; PROTEIN RHSA-RELATED; 1.
DR   Pfam; PF05593; RHS_repeat; 3.
DR   Pfam; PF03534; SpvB; 1.
DR   SUPFAM; SSF69318; Integrin alpha N-terminal domain; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT   TRANSMEM        1912..1930
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        1939..1959
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   2363 AA;  257426 MW;  681CC39D0E91E159 CRC64;
     MSSVASAIAG GIPQQLPILQ AGPDGTANTH IEIELPPGKV VPSLSLSYNS NGGNTIVGMG
     WSLNGLPTVV RNPSAGIGYN GNDSYVSGLA GELVDVSGNK TVYHSKKESY LRFEPQGTCG
     DGPCAWIATN QDGKRFLFGG SLDSRIPALG RTAGSIREWA LSREEDSHGN GYDVVYSTLD
     VNNGDYYPSA IVYNDRTIRF NYENRNDSNP NYSLGTLERI RKRLDTIEIF VGGVLFRTYD
     LDYSYGPVTG RSVLRKVQRS GSNTFGSENF ADLDFTYTNH SGGFSPGHLD YQNLSNTALM
     NVFIPNVAVD VLNFILNGAL PYHPSALDGS IDASLQYVVK VPVPDRDACN LGFASCLCAL
     IPICWGGNQQ FLQYLAQNCA GFLGWGGPGA CDNGVDSALT AWLPMDLNGD GIHDFATLNG
     NEADGSIHLA GHIQKIGQPA ITFNGPNIPI HYNTFYQVVD LNGDGLTDFV YENGGRLWGV
     YSTGGNFTSP VQFGNVSVTG ANGDMRVFSP YEYKFHYGPN HTTPLASDRA TRDFFGDVNG
     DELADFVHNN GGSFSIYINR ETYFDNPIVI GGGNDFYINS MIDFTGDGKS DYVQLVQTYD
     NSTLKTLQTQ KIALDALTVQ YQTEHARAKA VVDQMPTPTT NATIDDIEFQ NLLDYLTANG
     YDMVSDSLET DGKNYAYDPA FVSGLQTILE NLVGSKINFV GQQSYAINNQ IASIYAQGTL
     GQATYALQVR TFNITNGTSQ TQTFPISNSI DADKSTLADA NGDGVLDFVS FIGTQVSVSL
     FLGNGFSSPI VTNLNASNGK NLLQFNFGEV NGDGLADLVL FNKESQRIET YLARGDGTFS
     YSPGYSFGGF SIQEYTDPNG IERSDTYQIS LQDMNLDGIS DVSIAFLSLD KTWGRMYYRY
     NTARNSGEDQ LLTVTNGAGQ NSQVQYQLKN SHPGALQAGS GNYPNVPSMT PGFLVTQTRQ
     DLSNGIVQTT NYGYTNERHY QGTRNVSRSL GFASVRETNA NTNFYKITDY FQTDSRLAGA
     VQNQRSYNAS GNLTGSTSNT GFSFPNPFGT EVAVPGAVTT NEYRNGTLVE TSIRNFSYDS
     YGFTTSVVES LGSHTITNTT QVLNDVATWR MGRILRSRKN VDGTWIEDVS FGYTGDNVTS
     KTIFPSSASP ITTTFGYDTF GNVISVNDPA SGTSTITYDP VFNHFPVTKT NALGHVTTTN
     YDFATGLEIS VTDPNGAITQ TSYDPYGRKA SVVYPGESSP NETYSYNNTG EYDLANLNNN
     ESVTKTIRDN VSGSVNVSKI YRDPFGNTIR TETNTALSGV NTIENSYFDY PNGRLLQTTK
     PYLSVQTPQV VTYQYNDPDG VLTSITEPSA SGSVQTNITK TGFTETRTTT YPDGQTVTQV
     EIKNELGQTI SKTENGRTIS TSYSPFGEVS SITDAGGLTT TFTYNTLGRR VSTQDPNSGT
     ISFGYDTVGR ISSQTDARGK TIQFTYDTLG RALTQTTNGS EAPVQFTYDE PSVPFSRGRL
     TSVTDGSGRS EFRYSQKGNA IQKTRYVDDI TAIFKTDYDS LNRPITETLP DGTKLHNFYS
     PNGTLSSITM DSADGTSSGH TVVSYQGPYL DSNGVPNLKR TSGNGVTMEI GFEPLDKRPL
     RVVSKKPDGS VIANTELSYD AKGNITRIED KINPARTQNF TLDNLGRVTQ GTGKYGTQNY
     SFSANGNLIQ KGAYTLGYTD GNHANAVTTA TSASTGTLNY GYDASGNMIS RNGDVLRYDS
     YGKLVEITPY AASSSVRNTY DFAGNRVKSV SDITLISTYT LGENYEILRE PGKPEKHTLY
     VRGLHGDLVA QWTREDATLQ IAAANEVISS ESSISVFGWF VGRTIVGTPT EEDRSKRSRI
     SLFVGVPTNP FCKDVVGDCG SYYKNRVRSE FFGIFGYSKY FQGGVPTSRY NVFYYLLLLG
     ILYLSYPYFL KGNELLQRLG WKGVGTPALI LSLFVVTSLP GCGILPGTGG KQGDPPWVLA
     LGANVTPGVP SIQNPGVGMT GGGSVGGVPV TGMFFFHPDH LGSITMITDG AGNPASGPEP
     GTSFVSYEPY GSIIRNDSYG PDIFRYKFTG QIEDKETGLY YYKARYYEPT LGRFLQADSV
     IDSDAPNGQN RYMYVEGNPV NYRDPSGHSL DLMFYAALYQ YAQIPNSPEK DNSNLMLLVL
     HNQQIRNTSG PGCPISGKNR AVWGNFQGAG MCGGKLPKNV EFWMNVIFAS AAYSGTDSGP
     AIALAYYFLY KPNSALTIVD RSGIAHDEKH SWDLNKKAIH ANEDWIKQSW GNFYSINEQR
     AAYKREYDAL PKSYDRYGGT GKSVIAGVNY VGTTAVDSIA LRLGTIIFGI QNVMGYGYFW
     INHATFVHKG RYNNFWKPNK WKL
//