ID M7AJ16_CHEMY Unreviewed; 482 AA.
AC M7AJ16;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=CASP8 and FADD-like apoptosis regulator {ECO:0000313|EMBL:EMP24339.1};
DE Flags: Fragment;
GN ORFNames=UY3_18575 {ECO:0000313|EMBL:EMP24339.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP24339.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB601989; EMP24339.1; -; Genomic_DNA.
DR AlphaFoldDB; M7AJ16; -.
DR STRING; 8469.M7AJ16; -.
DR eggNOG; KOG3573; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08337; DED_c-FLIP_r1; 1.
DR CDD; cd08340; DED_c-FLIP_r2; 1.
DR Gene3D; 3.40.50.1460; -; 2.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR48169:SF4; CASP8 AND FADD LIKE APOPTOSIS REGULATOR; 1.
DR PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01335; DED; 2.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SMART; SM00031; DED; 2.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS50168; DED; 2.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..72
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 91..169
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 264..360
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EMP24339.1"
FT NON_TER 482
FT /evidence="ECO:0000313|EMBL:EMP24339.1"
SQ SEQUENCE 482 AA; 55381 MW; 92BD91C16B5AC7B3 CRC64;
VPAALIHQIE QELDEDEKEM MFFLCRDLVP DLSNTDIRDL LGVLNEKGKL PLGLSELLYR
VRRFDLLRRA LRTERTAVET DLARYPRMVS DYRVLMVEIN EELDKKEVGS LIFLLKDYVP
RMKMAKEKSF LAVVSDLEKL NLVAPNQLDL IEDCLQNIHR IDLKKKIQRY KCEALSNSGS
QPVYINALQA SLPNLTLIDP PYSSGIPNMN KERSLNGQHA IQTEPVHTSV QESGATSSQV
YDDQYRMQSR PLGICLIIDC IGNDTDILED TFKSLGFEVH CYRYLSVEAM NQTFHEVARL
QKHRDYDSFI CVLVSRGSPQ SIFCTDQTFP GYPLDRVKNF FTGDSCPELL GKPKLFFIQS
YIVPADQQEP TSLLEVDGNE QKITPNTRRP WNCSIPPVAD IFWSQCKVDV SVLERSPSSS
SSYLCCLAQL LRNPHKRKLP LLDIHIELNS RVYDYNRTLD PQQQYSLLLQ HTLRKKLFFP
PS
//
