ID M7AQR3_CHEMY Unreviewed; 261 AA.
AC M7AQR3;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase type-2 {ECO:0000313|EMBL:EMP26949.1};
GN ORFNames=UY3_15961 {ECO:0000313|EMBL:EMP26949.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP26949.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=17beta-estradiol + NAD(+) = estrone + H(+) + NADH;
CC Xref=Rhea:RHEA:24612, ChEBI:CHEBI:15378, ChEBI:CHEBI:16469,
CC ChEBI:CHEBI:17263, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.62;
CC Evidence={ECO:0000256|ARBA:ARBA00036587};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24613;
CC Evidence={ECO:0000256|ARBA:ARBA00036587};
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484, ECO:0000256|RuleBase:RU000363}.
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DR EMBL; KB575110; EMP26949.1; -; Genomic_DNA.
DR RefSeq; XP_007069249.1; XM_007069187.1.
DR AlphaFoldDB; M7AQR3; -.
DR STRING; 8469.M7AQR3; -.
DR GeneID; 102935413; -.
DR KEGG; cmy:102935413; -.
DR CTD; 3028; -.
DR eggNOG; KOG1199; Eukaryota.
DR OrthoDB; 149879at2759; -.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd05371; HSD10-like_SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR43658:SF8; 3-HYDROXYACYL-COA DEHYDROGENASE TYPE-2; 1.
DR PANTHER; PTHR43658; SHORT-CHAIN DEHYDROGENASE/REDUCTASE; 1.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443}.
SQ SEQUENCE 261 AA; 27075 MW; 07EBFB12CC08E251 CRC64;
MAAALRSVKG MVGLVTGGAS GLGRATAERL VQQGASAVIV DLPTSDGPSV AKVLGEQCVF
APADVTSEAD VKGVLDLVRE KFGRLDLAVN CAGIAVAVKT YNAKKDMPHS LEDFQRVLNV
NVAGTFNVIR LSAGEMGKNA PDSDGHRGVI VNTASVAAFE GQVGQAAYSA SKGGIVGMTL
PIARDLAPMG IRVITIAPGL FATPLLAGLP EKVRTFLARQ VPFPSRLGLP GEYAHLVQCI
VENPMLNGEV IRLDGAIRLQ P
//
