ID M7AY07_CHEMY Unreviewed; 757 AA.
AC M7AY07;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Single-minded like protein 1 {ECO:0000313|EMBL:EMP29634.1};
DE Flags: Fragment;
GN ORFNames=UY3_13252 {ECO:0000313|EMBL:EMP29634.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP29634.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
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DR EMBL; KB554904; EMP29634.1; -; Genomic_DNA.
DR RefSeq; XP_007066418.1; XM_007066356.1.
DR AlphaFoldDB; M7AY07; -.
DR STRING; 8469.M7AY07; -.
DR eggNOG; KOG3559; Eukaryota.
DR OrthoDB; 5396877at2759; -.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd19738; bHLH-PAS_SIM1; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR010578; SIM_C.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR PANTHER; PTHR23043:SF22; SINGLE-MINDED HOMOLOG 1; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF06621; SIM_C; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
DR PROSITE; PS51302; SIM_C; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..53
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 77..140
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 224..261
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 327..757
FT /note="Single-minded C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51302"
FT REGION 346..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 623..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..553
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..653
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 757
FT /evidence="ECO:0000313|EMBL:EMP29634.1"
SQ SEQUENCE 757 AA; 85035 MW; E59B0F9D64FBB6D3 CRC64;
MKEKSKNAAR TRREKENSEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL KMRVVFPEGL
GEAWGHTSRT SPLDNVGREL GSHLLQTLDG FIFVVAPDGK IMYISETASV HLGLSQVELT
GNSIYEYIHP ADHDEMTAVL TAHQPYHSHF VQEYEIERSF FLRMKCVLAK RNAGLTCGGY
KIFRVLAACK VPARSYQNVG LVAVGHSLPP SAVTEIKLHS NMFMFRASLD MKLIFLDSRV
AELTGYEPQD LIEKTLYHHV HGCDTFHLRC AHHLLLVKGQ VTTKYYRFLA KHGGWVWVQS
YATIVHNSRS SRPHCIVSVN YVLTDTEYKG LQLSLDQVTA TKPSFSYANS TPTITDNRKG
SKSRLSSTKS KSRTSPYPQY SGFHTERSES DHESQWGGSP LTDTASPQLM EPAERPSSQH
HDVSCAYRQY SDRSSLCYGF ALDHSRLTDD RHFHTQACEG GRCEAGRYFL GTPQPGRDTW
WGSRSALPLT KTSPESREAY ENSMPHITSV HRIHGRGHWD EDSVVSSPDP GSASESGDRY
RTEQYQSSPH EPSKIETLIR ATQQMIKEEE NRLQLQKTTP DQLVSINGAG KKHSICFANY
QPQQLTGDVC RVPTVANTSP CEHIQQRDGK LMSPHENDYD NSPTTLSRIS SPNSDRISKS
SLILAKDYLH SDMSPHQATA DHPAASPNYY TSHRQYFDKH AYTLTGYALE HLYDSETIRN
YSLGCNGSHF DVTSHLRMQQ DPAQGHKGTS VIITNGS
//
