ID M7B8D8_CHEMY Unreviewed; 1267 AA.
AC M7B8D8;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=NACHT, LRR and PYD domains-containing protein 12 {ECO:0000313|EMBL:EMP24527.1};
GN ORFNames=UY3_18452 {ECO:0000313|EMBL:EMP24527.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP24527.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- SIMILARITY: Belongs to the NLRP family.
CC {ECO:0000256|ARBA:ARBA00008665}.
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DR EMBL; KB600878; EMP24527.1; -; Genomic_DNA.
DR AlphaFoldDB; M7B8D8; -.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd08321; Pyrin_ASC-like; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR013294; LBH.
DR InterPro; IPR038990; LBH_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR029495; NACHT-assoc.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45690; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 12; 1.
DR PANTHER; PTHR45690:SF15; NACHT, LRR AND PYD DOMAINS-CONTAINING PROTEIN 14; 1.
DR Pfam; PF14484; FISNA; 1.
DR Pfam; PF15317; Lbh; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR Pfam; PF02758; PYRIN; 1.
DR PRINTS; PR01881; LBHPROTEIN.
DR SMART; SM01288; FISNA; 1.
DR SMART; SM00368; LRR_RI; 4.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000031443}.
FT DOMAIN 1..92
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 183..385
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REGION 1216..1239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1267 AA; 143654 MW; D41CCAD991995F2E CRC64;
MTETYQDILL MILEELAEEQ RKKFKLKLGD TELRKGYANI PKGRLEKADV TDMVDLLIRY
YQEEYAVEVV INVLDHINDK DLAERLRRKS AEDHRANYVA SVKEKFRRVK DYNSRPGEWV
SLEDHYTKLF IVKKHHQAED KEHELLSRGK RHMEIMRKPS SFANSHVNVE DLFDTLSDGT
ITRKVILQGI AGIGKTATVS KIMYDWSSGR LYQGRFDYIF HWSCRELNQR TEKLSLAQLI
LQNWGHPKPE IGEILSCPDK VLFVIDGFDE LKFPEDYDKS KSLSCDLNTP HSTAAAVVES
LLSSKSLSEA CLLVTTRPLA VGMLETHMQG DLWAEIVGFL EEDRKEFFKK FFKDEEKAAF
AYSYIQENDV VFTMCFIPLI CWIVCTTLSL RLRHSEALDQ KVSTTTEIFT YFVATLLQSH
GCAQTSTQDL FHNLGSLAYA GVRDQKVLFD ESTLRKCNLE VSKGPSTFLT ELLQADIFVE
TIYSFVHLTV QELFAALFTF WNKEKASELL KEAFVENKSH LILTVRFLFG LNNDKSLKPL
KRYYETCMGI SKNELLKWTK KALLICQEQG EQNHLLLELL HCLFEIQDEE FVISALEEIK
EVVFLENNLG QDDQQVILYT LQHAKEFNQL KLGSLKERDM MKLVPLLGKC KQIQITLDNL
PEDTAIAICD HVIPAHPGIV ALDVNRIQGS EEFVKSLKNS LLDSDCRLES VGFNIENPRL
QAFQDICQHL ATYRSPRKFL LFRRYEEDEI HFGYEAKDEE KSGKSAVLAC LPEECFLELT
MWVTSTFTPL ALCLDENSIN DELMKTICEN LNSTNYQLQS LSLRSCSITQ ESMANICSLF
LCNTAVSLDL QSNPVGDEGV KLLATCLKSK GCCLEKLSLS SAALTEDCVP AITSLFSRKN
TLIWLDLSFN HLGDGGVKAL CSALKDKESH LEKLMIFLPT EYMGPNPEVS TQTKLLMVSV
QGLVYRWKCM QIKIRQPKIE TNSALFSSAS TWRQQELENR ELQLIKQMAL CNFSHSQDCP
DYLRSAEMTE VMMNTTSMDE IGLSPRKDGL SYQIFPDPSD FDRYCKLKDR LPSIVVEPTE
GDVESEDQHK TYALNMGLGG SEDRHSPPPT QSQRFHTVLQ RRKRKELPVC TQGSSCIDKE
RRSHAASSMD LGGGEVQNSF ATHLPTSATN KAQVLQTTVS FATQRRVIPR AGAPGDIGHG
YAREFTAAPM PLNCSISMSE SSPTGSTTPA PTSSREKLSR QCSTVHTSAY VGVTYVTRGV
CVIYSHP
//
