ID   M7BHW0_CHEMY            Unreviewed;       735 AA.
AC   M7BHW0;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=Acylamino-acid-releasing enzyme {ECO:0000256|ARBA:ARBA00018421};
DE            EC=3.4.19.1 {ECO:0000256|ARBA:ARBA00012917};
GN   ORFNames=UY3_15090 {ECO:0000313|EMBL:EMP27807.1};
OS   Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC   Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX   NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP27807.1, ECO:0000313|Proteomes:UP000031443};
RN   [1] {ECO:0000313|Proteomes:UP000031443}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA   White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA   Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA   Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA   Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT   into the development and evolution of the turtle-specific body plan.";
RL   Nat. Genet. 45:701-706(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Cleavage of an N-acetyl or N-formyl amino acid from the N-
CC         terminus of a polypeptide.; EC=3.4.19.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000721};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   EMBL; KB566894; EMP27807.1; -; Genomic_DNA.
DR   AlphaFoldDB; M7BHW0; -.
DR   STRING; 8469.M7BHW0; -.
DR   MEROPS; S09.004; -.
DR   eggNOG; KOG2100; Eukaryota.
DR   Proteomes; UP000031443; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR045550; AARE_N.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR001375; Peptidase_S9.
DR   PANTHER; PTHR42776:SF4; ACYLAMINO-ACID-RELEASING ENZYME; 1.
DR   PANTHER; PTHR42776; SERINE PEPTIDASE S9 FAMILY MEMBER; 1.
DR   Pfam; PF19283; APEH_N; 1.
DR   Pfam; PF00326; Peptidase_S9; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF50993; Peptidase/esterase 'gauge' domain; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031443}.
FT   DOMAIN          27..290
FT                   /note="Acylamino-acid-releasing enzyme N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19283"
FT   DOMAIN          525..734
FT                   /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00326"
SQ   SEQUENCE   735 AA;  81552 MW;  D11705280853312B CRC64;
     MQTARPTRSP QHHVLRSPEE IAAVYRELSQ CPSLCSACIG PEVTTQYGGK YCNVYTEWSQ
     QDLERAESVK FCRQYLIFHD SQAIVYSGPS GTCSEIKGEL LSRESPSGAL KAVLRKASPG
     KGEEKQFLEI WDQNRKVKSI NLTVLEKHGN VYEDDQFGCL SWSHSETHLL YVAERKRPKA
     ESFFQSRTPE LSSNCADERR DKAVKGEQFV YHDDWGEALV GKSVPALCVL DVESGNVSVL
     EGIPEHISPG QAFWSPGDTG VVFIGWWHEP FRLGLRHCTN RRSALFYVDL TGARCELLSD
     DTKAVWSPRL SPDQCRIVYL ENSALGPHQQ CSRLRVYDWY TKVTSTALDV VSRHSQGTFT
     GIYCPALPGL CWAADSQRVV LDTAQRSRQE LLVVETLSGS VTSLTMGAPL GSWSLLTIDR
     DLLVARFSTP SCPPTLKVAF LPGAGREAQV HWVCLEDVTP IPEISWVIRP LQPPPDQENP
     QYKGIDFEAI LLQPSKGLGL RKLPLVVMPH GGPHSVCTAS WMLYPAVLCR IGFAVLLVNY
     RGSLGFGQDS IASLPGHVGC QDVKDVQYCV ERVLQEEPLD SARVALVGGS HGGFLACHLI
     GQYPGTYQAC VARNPVINMA SMISSTDIPD WCLTEAGFPY APDTLPDACH WAEMLHMSPM
     QYVAQVRAPV LLMLGEEDRR VPPKQGLEYY RALKARGVPA RLLLYPRNSH ALSGVEAEAD
     GFMNMVLWLL QHLQC
//